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Longitudinal relationships of metabolic syndrome and obesity with kidney function: Healthy Twin Study.
Clin Exp Nephrol. 2015 Oct; 19(5):887-94.CE

Abstract

BACKGROUND

To examine cross-sectional and longitudinal relationships, including genetic and environmental correlations, of metabolic syndrome (MetS) and obesity with kidney function.

METHODS

Subjects were 3,437 Korean adults of the Healthy Twin Study for cross-sectional relationships and 1,881 participants for longitudinal relationships (follow-up interval 3.7 ± 1.4 years). Obesity (body mass index ≥ 25 vs. <25 kg/m(2)), MetS, and chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) (<60 mL/min/1.73 m(2) using the modification of diet in renal disease study equation)] were categorized at baseline and follow-up.

RESULTS

The prevalence and incidence of chronic kidney disease were 2.5 and 3.3 %, respectively. Compared to individuals without obesity and MetS, prevalent CKD was associated with MetS regardless of weight status [adjusted odds ratio (AOR) 4.19 for those with MetS but without obesity; AOR 4.63 for those with MetS and obesity]. Incident CKD was associated with obesity regardless of baseline metabolic status (AOR 2.03 for those with obesity but without MetS; AOR 2.85 for those with obesity and MetS). MetS at follow-up was associated with incident CKD regardless of baseline MetS (AOR 2.42-2.52). Sex-adjusted bivariate analyses show inverse environmental correlations of the number of MetS components and BMI at baseline, with eGFR at baseline and follow-up (ρ E, -0.26 to -0.42, P < 0.001).

CONCLUSIONS

MetS predicts prevalent CKD regardless of obesity, and obesity predicts incident CKD regardless of baseline MetS. Incident CKD is also associated with MetS at follow-up regardless of baseline MetS. These associations appear to be explained by shared environmental factors.

Authors+Show Affiliations

Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, South Korea.Department of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea. Institute of Health and Environment, Seoul National University, Seoul, South Korea.Department of Family Medicine, Busan Paik Hospital, Inje University College of Medicine, 633-165 Gaegum-dong, Busan Jin-Gu, Busan, 614-735, South Korea. kayoung.fmlky@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

25634252

Citation

Song, Yun-Mi, et al. "Longitudinal Relationships of Metabolic Syndrome and Obesity With Kidney Function: Healthy Twin Study." Clinical and Experimental Nephrology, vol. 19, no. 5, 2015, pp. 887-94.
Song YM, Sung J, Lee K. Longitudinal relationships of metabolic syndrome and obesity with kidney function: Healthy Twin Study. Clin Exp Nephrol. 2015;19(5):887-94.
Song, Y. M., Sung, J., & Lee, K. (2015). Longitudinal relationships of metabolic syndrome and obesity with kidney function: Healthy Twin Study. Clinical and Experimental Nephrology, 19(5), 887-94. https://doi.org/10.1007/s10157-015-1083-5
Song YM, Sung J, Lee K. Longitudinal Relationships of Metabolic Syndrome and Obesity With Kidney Function: Healthy Twin Study. Clin Exp Nephrol. 2015;19(5):887-94. PubMed PMID: 25634252.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal relationships of metabolic syndrome and obesity with kidney function: Healthy Twin Study. AU - Song,Yun-Mi, AU - Sung,Joohon, AU - Lee,Kayoung, Y1 - 2015/01/30/ PY - 2014/12/11/received PY - 2015/01/13/accepted PY - 2015/1/31/entrez PY - 2015/1/31/pubmed PY - 2016/7/28/medline KW - Chronic kidney disease KW - Metabolic syndrome KW - Obesity SP - 887 EP - 94 JF - Clinical and experimental nephrology JO - Clin Exp Nephrol VL - 19 IS - 5 N2 - BACKGROUND: To examine cross-sectional and longitudinal relationships, including genetic and environmental correlations, of metabolic syndrome (MetS) and obesity with kidney function. METHODS: Subjects were 3,437 Korean adults of the Healthy Twin Study for cross-sectional relationships and 1,881 participants for longitudinal relationships (follow-up interval 3.7 ± 1.4 years). Obesity (body mass index ≥ 25 vs. <25 kg/m(2)), MetS, and chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) (<60 mL/min/1.73 m(2) using the modification of diet in renal disease study equation)] were categorized at baseline and follow-up. RESULTS: The prevalence and incidence of chronic kidney disease were 2.5 and 3.3 %, respectively. Compared to individuals without obesity and MetS, prevalent CKD was associated with MetS regardless of weight status [adjusted odds ratio (AOR) 4.19 for those with MetS but without obesity; AOR 4.63 for those with MetS and obesity]. Incident CKD was associated with obesity regardless of baseline metabolic status (AOR 2.03 for those with obesity but without MetS; AOR 2.85 for those with obesity and MetS). MetS at follow-up was associated with incident CKD regardless of baseline MetS (AOR 2.42-2.52). Sex-adjusted bivariate analyses show inverse environmental correlations of the number of MetS components and BMI at baseline, with eGFR at baseline and follow-up (ρ E, -0.26 to -0.42, P < 0.001). CONCLUSIONS: MetS predicts prevalent CKD regardless of obesity, and obesity predicts incident CKD regardless of baseline MetS. Incident CKD is also associated with MetS at follow-up regardless of baseline MetS. These associations appear to be explained by shared environmental factors. SN - 1437-7799 UR - https://www.unboundmedicine.com/medline/citation/25634252/Longitudinal_relationships_of_metabolic_syndrome_and_obesity_with_kidney_function:_Healthy_Twin_Study_ L2 - https://dx.doi.org/10.1007/s10157-015-1083-5 DB - PRIME DP - Unbound Medicine ER -