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Alcohol drinking pattern and risk of alcoholic liver cirrhosis: a prospective cohort study.
J Hepatol 2015; 62(5):1061-7JH

Abstract

BACKGROUND & AIMS

Alcohol is the main contributing factor of alcoholic cirrhosis, but less is known about the significance of drinking pattern.

METHODS

We investigated the risk of alcoholic cirrhosis among 55,917 participants (aged 50-64 years) in the Danish Cancer, Diet, and Health study (1993-2011). Baseline information on alcohol intake, drinking pattern, and confounders was obtained from a questionnaire. Follow-up information came from national registers. We calculated hazard ratios (HRs) for alcoholic cirrhosis in relation to drinking frequency, lifetime alcohol amount, and beverage type.

RESULTS

We observed 257 and 85 incident cases of alcoholic cirrhosis among men and women, respectively, none among lifetime abstainers. In men, HR for alcoholic cirrhosis among daily drinkers was 3.65 (95% CI: 2.39; 5.55) compared to drinking 2-4 days/week. Alcohol amount in recent age periods (40-49 and 50-59 years) was associated with an increased risk, whereas the amount in 20-29 and 30-39 years was not. In men drinking 14-28 drinks/week, HR was 7.47 (95% CI: 1.68; 33.12), 3.12 (95% CI: 1.53; 6.39), and 1.69 (95% CI: 0.79; 3.65) in drinkers of little (<1% of weekly amount), some (1-15%), and mostly wine (50-100%), compared to drinking <14 drinks/week. In general, results were similar for women.

CONCLUSIONS

In men, daily drinking was associated with an increased risk of alcoholic cirrhosis. Recent alcohol consumption rather than earlier in life was associated with risk of alcoholic cirrhosis. Compared to beer and liquor, wine might be associated with a lower risk of alcoholic cirrhosis.

Authors+Show Affiliations

Department of Hepatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen DK-2100, Denmark; National Institute of Public Health, University of Southern Denmark, Copenhagen DK-1353, Denmark. Electronic address: gask@dadlnet.dk.National Institute of Public Health, University of Southern Denmark, Copenhagen DK-1353, Denmark.Department of Hepatology, Copenhagen University Hospital, Rigshospitalet, Copenhagen DK-2100, Denmark.Danish Cancer Society Research Center, Copenhagen DK-2100, Denmark.National Institute of Public Health, University of Southern Denmark, Copenhagen DK-1353, Denmark.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25634330

Citation

Askgaard, Gro, et al. "Alcohol Drinking Pattern and Risk of Alcoholic Liver Cirrhosis: a Prospective Cohort Study." Journal of Hepatology, vol. 62, no. 5, 2015, pp. 1061-7.
Askgaard G, Grønbæk M, Kjær MS, et al. Alcohol drinking pattern and risk of alcoholic liver cirrhosis: a prospective cohort study. J Hepatol. 2015;62(5):1061-7.
Askgaard, G., Grønbæk, M., Kjær, M. S., Tjønneland, A., & Tolstrup, J. S. (2015). Alcohol drinking pattern and risk of alcoholic liver cirrhosis: a prospective cohort study. Journal of Hepatology, 62(5), pp. 1061-7. doi:10.1016/j.jhep.2014.12.005.
Askgaard G, et al. Alcohol Drinking Pattern and Risk of Alcoholic Liver Cirrhosis: a Prospective Cohort Study. J Hepatol. 2015;62(5):1061-7. PubMed PMID: 25634330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol drinking pattern and risk of alcoholic liver cirrhosis: a prospective cohort study. AU - Askgaard,Gro, AU - Grønbæk,Morten, AU - Kjær,Mette S, AU - Tjønneland,Anne, AU - Tolstrup,Janne S, Y1 - 2015/01/26/ PY - 2014/08/12/received PY - 2014/11/09/revised PY - 2014/12/03/accepted PY - 2015/1/31/entrez PY - 2015/1/31/pubmed PY - 2016/1/26/medline KW - Alcohol KW - Alcoholic beverages KW - Cohort study KW - Drinking pattern KW - Epidemiological methods KW - Liver cirrhosis SP - 1061 EP - 7 JF - Journal of hepatology JO - J. Hepatol. VL - 62 IS - 5 N2 - BACKGROUND & AIMS: Alcohol is the main contributing factor of alcoholic cirrhosis, but less is known about the significance of drinking pattern. METHODS: We investigated the risk of alcoholic cirrhosis among 55,917 participants (aged 50-64 years) in the Danish Cancer, Diet, and Health study (1993-2011). Baseline information on alcohol intake, drinking pattern, and confounders was obtained from a questionnaire. Follow-up information came from national registers. We calculated hazard ratios (HRs) for alcoholic cirrhosis in relation to drinking frequency, lifetime alcohol amount, and beverage type. RESULTS: We observed 257 and 85 incident cases of alcoholic cirrhosis among men and women, respectively, none among lifetime abstainers. In men, HR for alcoholic cirrhosis among daily drinkers was 3.65 (95% CI: 2.39; 5.55) compared to drinking 2-4 days/week. Alcohol amount in recent age periods (40-49 and 50-59 years) was associated with an increased risk, whereas the amount in 20-29 and 30-39 years was not. In men drinking 14-28 drinks/week, HR was 7.47 (95% CI: 1.68; 33.12), 3.12 (95% CI: 1.53; 6.39), and 1.69 (95% CI: 0.79; 3.65) in drinkers of little (<1% of weekly amount), some (1-15%), and mostly wine (50-100%), compared to drinking <14 drinks/week. In general, results were similar for women. CONCLUSIONS: In men, daily drinking was associated with an increased risk of alcoholic cirrhosis. Recent alcohol consumption rather than earlier in life was associated with risk of alcoholic cirrhosis. Compared to beer and liquor, wine might be associated with a lower risk of alcoholic cirrhosis. SN - 1600-0641 UR - https://www.unboundmedicine.com/medline/citation/25634330/Alcohol_drinking_pattern_and_risk_of_alcoholic_liver_cirrhosis:_a_prospective_cohort_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8278(14)00923-4 DB - PRIME DP - Unbound Medicine ER -