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Blood pressure control and acceptability of perindopril and its fixed dose combinations with amlodipine or indapamide, in younger patients with hypertension.

Abstract

OBJECTIVE

Recent hypertension guidelines recommend initiation of treatment with a fixed dose combination of two drugs for more effective and quicker blood pressure control. Few of these have been assessed for efficacy and acceptability. This study examines the short term blood pressure control and acceptability of perindopril, with or without its fixed dose combinations (FDC) with amlodipine and Indapamide in younger patients.

METHODS

In a multicentre prospective observational study, patients with stage 1 hypertension were prescribed perindopril 4 mg per day. Those with stage 2 or 3 hypertension were prescribed a single tablet per day of 4 mg perindopril and 5 mg amlodipine (COVERSYL AM), or 4 mg perindopril and 1.25 mg indapamide (COVERSYL PLUS)for 45 days. The primary outcomes were the frequency of patients achieving blood pressure control and the adverse effect of pedal edema.

RESULTS

Of 426 patients, with a mean age of 45 years, distributed throughout India, and an average (SD) baseline systolic/diastolic blood pressure of 157.2 (13.5)/98.6 (7.4), 303 (71.1%) achieved blood pressure control. Mean (SD) SBP/DBP decreased from baseline by 26.9 (12.6), and DBP by 15.4 (7.2) mm Hg. Few patients discontinued treatment, and the frequency of cough that interfered with sleep and ankle edema was low.

CONCLUSION

In patients requiring combination antihypertensive treatment, the regimen of perindopril alone or its FDC with Indapamide or amlodipine reduces blood pressure effectively, resulting in high rates of blood pressure control over the short term, with a low frequency of side effects including cough and pedal edema.

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  • Authors+Show Affiliations

    ,

    Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi 110029, India. Electronic address: drsbansal2000@yahoo.com.

    ,

    4718/21, Dayanand Road Ansari Road, Daryaganj, New Delhi 110002, India.

    ,

    Sri Jayadeva Institute of Cardiology, 9th Block, Jayanagar, Bengaluru 5600069, India.

    ,

    New Noor Hospital, Kurla Depot (west), Mumbai 400070, India.

    GD Diabetes Hospital and Research Centre, 97, Park Street, Kolkata 700016, India.

    Source

    Indian heart journal 66:6 pg 635-9

    MeSH

    Adult
    Amlodipine
    Antihypertensive Agents
    Drug Combinations
    Female
    Humans
    Hypertension
    Indapamide
    India
    Male
    Middle Aged
    Perindopril
    Prospective Studies
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Multicenter Study
    Observational Study

    Language

    eng

    PubMed ID

    25634398

    Citation

    Bansal, Sandeep, et al. "Blood Pressure Control and Acceptability of Perindopril and Its Fixed Dose Combinations With Amlodipine or Indapamide, in Younger Patients With Hypertension." Indian Heart Journal, vol. 66, no. 6, 2014, pp. 635-9.
    Bansal S, Chauhan DK, Ramesh D, et al. Blood pressure control and acceptability of perindopril and its fixed dose combinations with amlodipine or indapamide, in younger patients with hypertension. Indian Heart J. 2014;66(6):635-9.
    Bansal, S., Chauhan, D. K., Ramesh, D., Barmare, S., & Chakraborty, S. (2014). Blood pressure control and acceptability of perindopril and its fixed dose combinations with amlodipine or indapamide, in younger patients with hypertension. Indian Heart Journal, 66(6), pp. 635-9. doi:10.1016/j.ihj.2014.10.419.
    Bansal S, et al. Blood Pressure Control and Acceptability of Perindopril and Its Fixed Dose Combinations With Amlodipine or Indapamide, in Younger Patients With Hypertension. Indian Heart J. 2014;66(6):635-9. PubMed PMID: 25634398.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Blood pressure control and acceptability of perindopril and its fixed dose combinations with amlodipine or indapamide, in younger patients with hypertension. AU - Bansal,Sandeep, AU - Chauhan,D K, AU - Ramesh,D, AU - Barmare,Shahid, AU - Chakraborty,Shaibal, Y1 - 2014/11/28/ PY - 2014/07/29/received PY - 2014/10/09/accepted PY - 2015/1/31/entrez PY - 2015/1/31/pubmed PY - 2016/10/25/medline KW - Amlodipine KW - FDC KW - Hypertension KW - Indapamide SP - 635 EP - 9 JF - Indian heart journal JO - Indian Heart J VL - 66 IS - 6 N2 - OBJECTIVE: Recent hypertension guidelines recommend initiation of treatment with a fixed dose combination of two drugs for more effective and quicker blood pressure control. Few of these have been assessed for efficacy and acceptability. This study examines the short term blood pressure control and acceptability of perindopril, with or without its fixed dose combinations (FDC) with amlodipine and Indapamide in younger patients. METHODS: In a multicentre prospective observational study, patients with stage 1 hypertension were prescribed perindopril 4 mg per day. Those with stage 2 or 3 hypertension were prescribed a single tablet per day of 4 mg perindopril and 5 mg amlodipine (COVERSYL AM), or 4 mg perindopril and 1.25 mg indapamide (COVERSYL PLUS)for 45 days. The primary outcomes were the frequency of patients achieving blood pressure control and the adverse effect of pedal edema. RESULTS: Of 426 patients, with a mean age of 45 years, distributed throughout India, and an average (SD) baseline systolic/diastolic blood pressure of 157.2 (13.5)/98.6 (7.4), 303 (71.1%) achieved blood pressure control. Mean (SD) SBP/DBP decreased from baseline by 26.9 (12.6), and DBP by 15.4 (7.2) mm Hg. Few patients discontinued treatment, and the frequency of cough that interfered with sleep and ankle edema was low. CONCLUSION: In patients requiring combination antihypertensive treatment, the regimen of perindopril alone or its FDC with Indapamide or amlodipine reduces blood pressure effectively, resulting in high rates of blood pressure control over the short term, with a low frequency of side effects including cough and pedal edema. SN - 0019-4832 UR - https://www.unboundmedicine.com/medline/citation/25634398/Blood_pressure_control_and_acceptability_of_perindopril_and_its_fixed_dose_combinations_with_amlodipine_or_indapamide,_in_younger_patients_with_hypertension L2 - https://linkinghub.elsevier.com/retrieve/pii/S0019-4832(14)00718-4 DB - PRIME DP - Unbound Medicine ER -