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Metabolically healthy obesity and risk of incident CKD.
Clin J Am Soc Nephrol 2015; 10(4):578-83CJ

Abstract

BACKGROUND AND OBJECTIVES

Metabolically healthy obesity (MHO) is a unique obesity phenotype that apparently protects people from the metabolic complications of obesity. The association between MHO phenotype and incident CKD is unclear. Thus, this study investigated the association between MHO phenotype and incident CKD.

DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS

A total of 3136 Japanese participants were enrolled in an 8-year follow-up cohort study in 2001. Metabolically healthy status was assessed by common clinical markers: BP, triglycerides, HDL cholesterol, and fasting plasma glucose concentrations. Body mass index ≥25.0 kg/m(2) was defined as obesity. CKD was defined by proteinuria or eGFR of <60 ml/min per 1.73 m(2). To calculate the odds ratio for incident CKD, logistic regression analyses were performed.

RESULTS

The crude incidence proportions of CKD were 2.6% (56 of 2122 participants) in participants with the metabolically healthy nonobesity phenotype, 2.6% (8 of 302) in those with the MHO phenotype, 6.7% (30 of 445) in those with the metabolically abnormal nonobesity phenotype, and 10.9% (29 of 267) in those with the metabolically abnormal obesity phenotype. Compared with metabolically healthy nonobesity phenotype, the odds ratios for incident CKD were 0.83 (95% confidence interval [95% CI], 0.36 to 1.72; P=0.64) for MHO, 1.44 (95% CI, 0.80 to 2.57; P=0.22) for metabolically abnormal nonobesity, and 2.80 (95% CI, 1.45 to 5.35; P=0.02) for metabolically abnormal obesity phenotype after adjustment for confounders, including age, sex, smoking statues, alcohol use, creatinine, uric acid, systolic BP, HDL cholesterol, and impaired fasting glucose or diabetes.

CONCLUSION

MHO phenotype was not associated with higher risk of incident CKD.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;Division of Metabolism, Nephrology and Rheumatology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan; and.Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;Division of Metabolism, Nephrology and Rheumatology, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan; and.Department of Internal Medicine, Oike Clinic, Kyoto, Japan.Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan;Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan; sayarinapm@hotmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25635035

Citation

Hashimoto, Yoshitaka, et al. "Metabolically Healthy Obesity and Risk of Incident CKD." Clinical Journal of the American Society of Nephrology : CJASN, vol. 10, no. 4, 2015, pp. 578-83.
Hashimoto Y, Tanaka M, Okada H, et al. Metabolically healthy obesity and risk of incident CKD. Clin J Am Soc Nephrol. 2015;10(4):578-83.
Hashimoto, Y., Tanaka, M., Okada, H., Senmaru, T., Hamaguchi, M., Asano, M., ... Fukui, M. (2015). Metabolically healthy obesity and risk of incident CKD. Clinical Journal of the American Society of Nephrology : CJASN, 10(4), pp. 578-83. doi:10.2215/CJN.08980914.
Hashimoto Y, et al. Metabolically Healthy Obesity and Risk of Incident CKD. Clin J Am Soc Nephrol. 2015 Apr 7;10(4):578-83. PubMed PMID: 25635035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolically healthy obesity and risk of incident CKD. AU - Hashimoto,Yoshitaka, AU - Tanaka,Muhei, AU - Okada,Hiroshi, AU - Senmaru,Takafumi, AU - Hamaguchi,Masahide, AU - Asano,Mai, AU - Yamazaki,Masahiro, AU - Oda,Yohei, AU - Hasegawa,Goji, AU - Toda,Hitoshi, AU - Nakamura,Naoto, AU - Fukui,Michiaki, Y1 - 2015/01/29/ PY - 2014/09/10/received PY - 2015/01/06/accepted PY - 2015/1/31/entrez PY - 2015/1/31/pubmed PY - 2016/1/9/medline KW - body mass index KW - chronic kidney disease KW - epidemiology and outcomes KW - obesity KW - proteinuria SP - 578 EP - 83 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 10 IS - 4 N2 - BACKGROUND AND OBJECTIVES: Metabolically healthy obesity (MHO) is a unique obesity phenotype that apparently protects people from the metabolic complications of obesity. The association between MHO phenotype and incident CKD is unclear. Thus, this study investigated the association between MHO phenotype and incident CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: A total of 3136 Japanese participants were enrolled in an 8-year follow-up cohort study in 2001. Metabolically healthy status was assessed by common clinical markers: BP, triglycerides, HDL cholesterol, and fasting plasma glucose concentrations. Body mass index ≥25.0 kg/m(2) was defined as obesity. CKD was defined by proteinuria or eGFR of <60 ml/min per 1.73 m(2). To calculate the odds ratio for incident CKD, logistic regression analyses were performed. RESULTS: The crude incidence proportions of CKD were 2.6% (56 of 2122 participants) in participants with the metabolically healthy nonobesity phenotype, 2.6% (8 of 302) in those with the MHO phenotype, 6.7% (30 of 445) in those with the metabolically abnormal nonobesity phenotype, and 10.9% (29 of 267) in those with the metabolically abnormal obesity phenotype. Compared with metabolically healthy nonobesity phenotype, the odds ratios for incident CKD were 0.83 (95% confidence interval [95% CI], 0.36 to 1.72; P=0.64) for MHO, 1.44 (95% CI, 0.80 to 2.57; P=0.22) for metabolically abnormal nonobesity, and 2.80 (95% CI, 1.45 to 5.35; P=0.02) for metabolically abnormal obesity phenotype after adjustment for confounders, including age, sex, smoking statues, alcohol use, creatinine, uric acid, systolic BP, HDL cholesterol, and impaired fasting glucose or diabetes. CONCLUSION: MHO phenotype was not associated with higher risk of incident CKD. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/25635035/Metabolically_healthy_obesity_and_risk_of_incident_CKD_ L2 - http://cjasn.asnjournals.org/cgi/pmidlookup?view=long&amp;pmid=25635035 DB - PRIME DP - Unbound Medicine ER -