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A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial.
Am J Geriatr Psychiatry. 2015 Nov; 23(11):1106-16.AJ

Abstract

OBJECTIVE

To compare training and follow-up effects of combined aerobic and strength training versus aerobic-only training on cognitive and motor function in institutionalized patients with dementia and to explore whether improved motor function mediates improved cognitive function.

METHODS

Using a 9-week, parallel, three-group, single-blind, randomized, controlled trial with a follow-up assessment at week 18, we assessed 109 patients with dementia (age 85.5 ± 5.1 years) in a psycho-geriatric nursing home. Each 9-week intervention consisted of 36, 30-minute sessions. A combined group (N = 37) received and completed two strength and two walking sessions per week, an aerobic group (N = 36) completed four walking sessions, and a social group (N = 36) completed four social visits per week. Cognitive and motor functions were assessed at baseline, after the 9-week intervention, and after a consecutive 9 weeks of usual care.

RESULTS

Baseline corrected post-test scores in the combined versus the social group were higher for global cognition, visual memory, verbal memory, executive function, walking endurance, leg muscle strength, and balance. Aerobic versus social group scores were higher for executive function. Follow-up effects reversed toward baseline values. Motor improvement did not significantly mediate cognitive improvement.

CONCLUSION

Compared with a nonexercise control group, a combination of aerobic and strength training is more effective than aerobic-only training in slowing cognitive and motor decline in patients with dementia. No mediating effects between improvements in cognitive function via improved motor function were found. Future research into the underlying mechanistic associations is needed.

Authors+Show Affiliations

Center for Human Movement Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. Electronic address: w.j.r.bossers@umcg.nl.Center for Human Movement Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Center for Rehabilitation, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Department of General Practice, Elderly Care Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Center for Human Movement Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.Center for Human Movement Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Department of Clinical Neuropsychology, VU University, Amsterdam, The Netherlands.Center for Human Movement Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25648055

Citation

Bossers, Willem J R., et al. "A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients With Dementia: a Randomized, Controlled Trial." The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, vol. 23, no. 11, 2015, pp. 1106-16.
Bossers WJ, van der Woude LH, Boersma F, et al. A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial. Am J Geriatr Psychiatry. 2015;23(11):1106-16.
Bossers, W. J., van der Woude, L. H., Boersma, F., Hortobágyi, T., Scherder, E. J., & van Heuvelen, M. J. (2015). A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial. The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry, 23(11), 1106-16. https://doi.org/10.1016/j.jagp.2014.12.191
Bossers WJ, et al. A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients With Dementia: a Randomized, Controlled Trial. Am J Geriatr Psychiatry. 2015;23(11):1106-16. PubMed PMID: 25648055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial. AU - Bossers,Willem J R, AU - van der Woude,Lucas H V, AU - Boersma,Froukje, AU - Hortobágyi,Tibor, AU - Scherder,Erik J A, AU - van Heuvelen,Marieke J G, Y1 - 2015/01/03/ PY - 2014/05/08/received PY - 2014/12/17/revised PY - 2014/12/25/accepted PY - 2015/2/5/entrez PY - 2015/2/5/pubmed PY - 2016/9/10/medline KW - Dementia KW - aerobic exercise KW - cognition KW - mediation KW - physical fitness KW - resistance training SP - 1106 EP - 16 JF - The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry JO - Am J Geriatr Psychiatry VL - 23 IS - 11 N2 - OBJECTIVE: To compare training and follow-up effects of combined aerobic and strength training versus aerobic-only training on cognitive and motor function in institutionalized patients with dementia and to explore whether improved motor function mediates improved cognitive function. METHODS: Using a 9-week, parallel, three-group, single-blind, randomized, controlled trial with a follow-up assessment at week 18, we assessed 109 patients with dementia (age 85.5 ± 5.1 years) in a psycho-geriatric nursing home. Each 9-week intervention consisted of 36, 30-minute sessions. A combined group (N = 37) received and completed two strength and two walking sessions per week, an aerobic group (N = 36) completed four walking sessions, and a social group (N = 36) completed four social visits per week. Cognitive and motor functions were assessed at baseline, after the 9-week intervention, and after a consecutive 9 weeks of usual care. RESULTS: Baseline corrected post-test scores in the combined versus the social group were higher for global cognition, visual memory, verbal memory, executive function, walking endurance, leg muscle strength, and balance. Aerobic versus social group scores were higher for executive function. Follow-up effects reversed toward baseline values. Motor improvement did not significantly mediate cognitive improvement. CONCLUSION: Compared with a nonexercise control group, a combination of aerobic and strength training is more effective than aerobic-only training in slowing cognitive and motor decline in patients with dementia. No mediating effects between improvements in cognitive function via improved motor function were found. Future research into the underlying mechanistic associations is needed. SN - 1545-7214 UR - https://www.unboundmedicine.com/medline/citation/25648055/A_9_Week_Aerobic_and_Strength_Training_Program_Improves_Cognitive_and_Motor_Function_in_Patients_with_Dementia:_A_Randomized_Controlled_Trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1064-7481(14)00572-7 DB - PRIME DP - Unbound Medicine ER -