Tags

Type your tag names separated by a space and hit enter

Adherence to the traditional Mediterranean diet and mortality in subjects with diabetes. Prospective results from the MOLI-SANI study.
Eur J Prev Cardiol. 2016 Mar; 23(4):400-7.EJ

Abstract

BACKGROUND

Adherence to the Mediterranean diet is associated with lower mortality in a general population but limited evidence exists on the effect of a Mediterranean diet on mortality in subjects with diabetes. We aim to examine the association between the Mediterranean diet and mortality in diabetic individuals.

DESIGN

Prospective cohort study on 1995 type 2 diabetic subjects recruited within the MOLI-SANI study.

METHODS

Food intake was recorded by the European Project Investigation into Cancer and Nutrition food frequency questionnaire. Adherence to the Mediterranean diet was appraised by the Greek Mediterranean diet score. Hazard ratios were calculated using multivariable Cox-proportional hazard models.

RESULTS

During follow-up (median 4.0 years), 109 all-cause including 51 cardiovascular deaths occurred. A 2-unit increase in Mediterranean diet score was associated with 37% (19%-51%) lower overall mortality. Data remained unchanged when restricted to those being on a hypoglycaemic diet or on antidiabetic drug treatment. A similar reduction was observed when cardiovascular mortality only was considered (hazard ratio = 0.66; 0.46-0.95). A Mediterranean diet-like pattern, originated from principal factor analysis, indicated a reduced risk of overall death (hazard ratio = 0.81; 0.62-1.07). The effect of Mediterranean diet score was mainly contributed by moderate alcohol drinking (14.7% in the reduction of the effect), high intake of cereals (12.2%), vegetables (5.8%) and reduced consumption of dairy and meat products (13.4% and 3.4% respectively).

CONCLUSIONS

The traditional Mediterranean diet was associated with reduced risk of both total and cardiovascular mortality in diabetic subjects, independently of the severity of the disease. Major contributions were offered by moderate alcohol intake, high consumption of cereals, fruits and nuts and reduced intake of dairy and meat products.

Authors+Show Affiliations

Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Italy marialaura.bonaccio@neuromed.it.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Italy.Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo NEUROMED, Italy.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25648935

Citation

Bonaccio, Marialaura, et al. "Adherence to the Traditional Mediterranean Diet and Mortality in Subjects With Diabetes. Prospective Results From the MOLI-SANI Study." European Journal of Preventive Cardiology, vol. 23, no. 4, 2016, pp. 400-7.
Bonaccio M, Di Castelnuovo A, Costanzo S, et al. Adherence to the traditional Mediterranean diet and mortality in subjects with diabetes. Prospective results from the MOLI-SANI study. Eur J Prev Cardiol. 2016;23(4):400-7.
Bonaccio, M., Di Castelnuovo, A., Costanzo, S., Persichillo, M., De Curtis, A., Donati, M. B., de Gaetano, G., & Iacoviello, L. (2016). Adherence to the traditional Mediterranean diet and mortality in subjects with diabetes. Prospective results from the MOLI-SANI study. European Journal of Preventive Cardiology, 23(4), 400-7. https://doi.org/10.1177/2047487315569409
Bonaccio M, et al. Adherence to the Traditional Mediterranean Diet and Mortality in Subjects With Diabetes. Prospective Results From the MOLI-SANI Study. Eur J Prev Cardiol. 2016;23(4):400-7. PubMed PMID: 25648935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adherence to the traditional Mediterranean diet and mortality in subjects with diabetes. Prospective results from the MOLI-SANI study. AU - Bonaccio,Marialaura, AU - Di Castelnuovo,Augusto, AU - Costanzo,Simona, AU - Persichillo,Mariarosaria, AU - De Curtis,Amalia, AU - Donati,Maria Benedetta, AU - de Gaetano,Giovanni, AU - Iacoviello,Licia, AU - ,, Y1 - 2015/02/03/ PY - 2014/07/12/received PY - 2015/01/06/accepted PY - 2015/2/5/entrez PY - 2015/2/5/pubmed PY - 2016/11/4/medline KW - Mediterranean diet KW - cardiovascular mortality KW - diabetes KW - overall mortality SP - 400 EP - 7 JF - European journal of preventive cardiology JO - Eur J Prev Cardiol VL - 23 IS - 4 N2 - BACKGROUND: Adherence to the Mediterranean diet is associated with lower mortality in a general population but limited evidence exists on the effect of a Mediterranean diet on mortality in subjects with diabetes. We aim to examine the association between the Mediterranean diet and mortality in diabetic individuals. DESIGN: Prospective cohort study on 1995 type 2 diabetic subjects recruited within the MOLI-SANI study. METHODS: Food intake was recorded by the European Project Investigation into Cancer and Nutrition food frequency questionnaire. Adherence to the Mediterranean diet was appraised by the Greek Mediterranean diet score. Hazard ratios were calculated using multivariable Cox-proportional hazard models. RESULTS: During follow-up (median 4.0 years), 109 all-cause including 51 cardiovascular deaths occurred. A 2-unit increase in Mediterranean diet score was associated with 37% (19%-51%) lower overall mortality. Data remained unchanged when restricted to those being on a hypoglycaemic diet or on antidiabetic drug treatment. A similar reduction was observed when cardiovascular mortality only was considered (hazard ratio = 0.66; 0.46-0.95). A Mediterranean diet-like pattern, originated from principal factor analysis, indicated a reduced risk of overall death (hazard ratio = 0.81; 0.62-1.07). The effect of Mediterranean diet score was mainly contributed by moderate alcohol drinking (14.7% in the reduction of the effect), high intake of cereals (12.2%), vegetables (5.8%) and reduced consumption of dairy and meat products (13.4% and 3.4% respectively). CONCLUSIONS: The traditional Mediterranean diet was associated with reduced risk of both total and cardiovascular mortality in diabetic subjects, independently of the severity of the disease. Major contributions were offered by moderate alcohol intake, high consumption of cereals, fruits and nuts and reduced intake of dairy and meat products. SN - 2047-4881 UR - https://www.unboundmedicine.com/medline/citation/25648935/Adherence_to_the_traditional_Mediterranean_diet_and_mortality_in_subjects_with_diabetes__Prospective_results_from_the_MOLI_SANI_study_ L2 - http://journals.sagepub.com/doi/full/10.1177/2047487315569409?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -