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Serum Vitamin D Concentrations and Cognitive Function in a Population-Based Study among Older Adults in South Germany.

Abstract

Our objective was to investigate the associations of vitamin D serum levels with dementia and cognitive function in specific domains in community dwelling older adults. Between 2009 and 2010, we conducted a cross-sectional study in 1,373 individuals (56% men) aged 65+ years in the "Activity and Function in the Elderly in Ulm" (ActiFE) study. Dementia was defined as a Mini-Mental State Examination (MMSE) score ≤ 24. The 25-OHD serum level [ng/mL] was measured by an electrochemilumineszenz immunoassay (ECLIA). Logistic regression models were used to calculate odds ratios (OR)s for cognitive domains (cut-point: 10th percentile) by serum 25-OHD concentrations (both continuously and by cut-point of 20 ng/ml for vitamin D deficiency). Mean age of the study population was 75.6 (SD 6.6) years.We identified 75 participants (43% women) with dementia. 25-OHD concentrations were significantly lower in the participants with dementia compared to persons with a MMSE score >24. We also observed an association of continuous 25-OHD serum concentrations with prevalence of dementia (crude OR 1.05, 95% confidence interval (CI), 1.01-1.08, p-value 0.009) per 1 ng/mL decrease, after adjustment the OR was 1.03, 95% CI, 0.995-1.08 (p-value 0.09). Although vitamin D deficiency was tentatively associated with severity of dementia measured by MMSE (OR 1.35, 95% CI, 0.84-2.19), the association was not statistically significant. However, deficits in specific cognitive domains such as executive functions, wordlist encoding, and visual memory (encoding and recall) were significantly associated with low vitamin D concentration. Our results suggest an association between vitamin D deficiency and cognitive function in specific domains in community dwelling older adults.

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  • Authors

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    MeSH

    Aged
    Aged, 80 and over
    Cognition
    Cross-Sectional Studies
    Dementia
    Female
    Germany
    Humans
    Immunoassay
    Logistic Models
    Male
    Neuropsychological Tests
    Odds Ratio
    Prevalence
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25649649

    Citation

    Nagel, Gabriele, et al. "Serum Vitamin D Concentrations and Cognitive Function in a Population-Based Study Among Older Adults in South Germany." Journal of Alzheimer's Disease : JAD, vol. 45, no. 4, 2015, pp. 1119-26.
    Nagel G, Herbolsheimer F, Riepe M, et al. Serum Vitamin D Concentrations and Cognitive Function in a Population-Based Study among Older Adults in South Germany. J Alzheimers Dis. 2015;45(4):1119-26.
    Nagel, G., Herbolsheimer, F., Riepe, M., Nikolaus, T., Denkinger, M. D., Peter, R., ... von Arnim, C. A. (2015). Serum Vitamin D Concentrations and Cognitive Function in a Population-Based Study among Older Adults in South Germany. Journal of Alzheimer's Disease : JAD, 45(4), pp. 1119-26.
    Nagel G, et al. Serum Vitamin D Concentrations and Cognitive Function in a Population-Based Study Among Older Adults in South Germany. J Alzheimers Dis. 2015;45(4):1119-26. PubMed PMID: 25649649.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Serum Vitamin D Concentrations and Cognitive Function in a Population-Based Study among Older Adults in South Germany. AU - Nagel,Gabriele, AU - Herbolsheimer,Florian, AU - Riepe,Matthias, AU - Nikolaus,Thorsten, AU - Denkinger,Michael D, AU - Peter,Richard, AU - Weinmayr,Gudrun, AU - Rothenbacher,Dietrich, AU - Koenig,Wolfgang, AU - Ludolph,Albert C, AU - von Arnim,Christine A F, AU - ,, PY - 2015/2/5/entrez PY - 2015/2/5/pubmed PY - 2016/3/10/medline SP - 1119 EP - 26 JF - Journal of Alzheimer's disease : JAD JO - J. Alzheimers Dis. VL - 45 IS - 4 N2 - Our objective was to investigate the associations of vitamin D serum levels with dementia and cognitive function in specific domains in community dwelling older adults. Between 2009 and 2010, we conducted a cross-sectional study in 1,373 individuals (56% men) aged 65+ years in the "Activity and Function in the Elderly in Ulm" (ActiFE) study. Dementia was defined as a Mini-Mental State Examination (MMSE) score ≤ 24. The 25-OHD serum level [ng/mL] was measured by an electrochemilumineszenz immunoassay (ECLIA). Logistic regression models were used to calculate odds ratios (OR)s for cognitive domains (cut-point: 10th percentile) by serum 25-OHD concentrations (both continuously and by cut-point of 20 ng/ml for vitamin D deficiency). Mean age of the study population was 75.6 (SD 6.6) years.We identified 75 participants (43% women) with dementia. 25-OHD concentrations were significantly lower in the participants with dementia compared to persons with a MMSE score >24. We also observed an association of continuous 25-OHD serum concentrations with prevalence of dementia (crude OR 1.05, 95% confidence interval (CI), 1.01-1.08, p-value 0.009) per 1 ng/mL decrease, after adjustment the OR was 1.03, 95% CI, 0.995-1.08 (p-value 0.09). Although vitamin D deficiency was tentatively associated with severity of dementia measured by MMSE (OR 1.35, 95% CI, 0.84-2.19), the association was not statistically significant. However, deficits in specific cognitive domains such as executive functions, wordlist encoding, and visual memory (encoding and recall) were significantly associated with low vitamin D concentration. Our results suggest an association between vitamin D deficiency and cognitive function in specific domains in community dwelling older adults. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/25649649/Serum_Vitamin_D_Concentrations_and_Cognitive_Function_in_a_Population_Based_Study_among_Older_Adults_in_South_Germany_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-143219 DB - PRIME DP - Unbound Medicine ER -