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Association between cholesterol intake and pancreatic cancer risk: evidence from a meta-analysis.

Abstract

Quantification of the association between the intake of cholesterol and risk of pancreatic cancer is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies of cholesterol intake and the risk of pancreatic cancer. Pertinent studies were delivered by PubMed and Web of Knowledge issued through April of 2014. A random effects model was used to process the data for analysis. Sensitivity analysis and publication bias were conducted. Dose-response relationship was assessed by restricted cubic spline and variance-weighted least squares regression analysis. With 4513 pancreatic cases exemplified, 16 articles were applied in the meta-analysis. Pooled results suggest that cholesterol intake level was significantly associated with the risk of pancreatic cancer [summary relative risk (RR) = 1.371, 95%CI = 1.155-1.627, I(2) = 58.2%], especially in America [summary RR = 1.302, 95%CI = 1.090-1.556]. A linear dose-response relation was attested that the risk of pancreatic cancer rises by 8% with 100 mg/day of cholesterol intake. [summary RR = 1.08, 95% CI = 1.04-1.13]. In conclusion, our analysis suggests that a high intake of cholesterol might increase the risk of pancreatic cancer, especially in America.

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  • Authors+Show Affiliations

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    ,

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    Department of General Surgery, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China.

    Source

    Scientific reports 5: 2015 Feb 04 pg 8243

    MeSH

    Cholesterol
    Diet
    Humans
    Odds Ratio
    Pancreatic Neoplasms
    Publication Bias
    Risk

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    25649888

    Citation

    Chen, Hongqiang, et al. "Association Between Cholesterol Intake and Pancreatic Cancer Risk: Evidence From a Meta-analysis." Scientific Reports, vol. 5, 2015, p. 8243.
    Chen H, Qin S, Wang M, et al. Association between cholesterol intake and pancreatic cancer risk: evidence from a meta-analysis. Sci Rep. 2015;5:8243.
    Chen, H., Qin, S., Wang, M., Zhang, T., & Zhang, S. (2015). Association between cholesterol intake and pancreatic cancer risk: evidence from a meta-analysis. Scientific Reports, 5, p. 8243. doi:10.1038/srep08243.
    Chen H, et al. Association Between Cholesterol Intake and Pancreatic Cancer Risk: Evidence From a Meta-analysis. Sci Rep. 2015 Feb 4;5:8243. PubMed PMID: 25649888.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between cholesterol intake and pancreatic cancer risk: evidence from a meta-analysis. AU - Chen,Hongqiang, AU - Qin,Shiyong, AU - Wang,Minghai, AU - Zhang,Tao, AU - Zhang,Shuguang, Y1 - 2015/02/04/ PY - 2014/08/12/received PY - 2014/12/16/accepted PY - 2015/2/5/entrez PY - 2015/2/5/pubmed PY - 2015/12/15/medline SP - 8243 EP - 8243 JF - Scientific reports JO - Sci Rep VL - 5 N2 - Quantification of the association between the intake of cholesterol and risk of pancreatic cancer is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies of cholesterol intake and the risk of pancreatic cancer. Pertinent studies were delivered by PubMed and Web of Knowledge issued through April of 2014. A random effects model was used to process the data for analysis. Sensitivity analysis and publication bias were conducted. Dose-response relationship was assessed by restricted cubic spline and variance-weighted least squares regression analysis. With 4513 pancreatic cases exemplified, 16 articles were applied in the meta-analysis. Pooled results suggest that cholesterol intake level was significantly associated with the risk of pancreatic cancer [summary relative risk (RR) = 1.371, 95%CI = 1.155-1.627, I(2) = 58.2%], especially in America [summary RR = 1.302, 95%CI = 1.090-1.556]. A linear dose-response relation was attested that the risk of pancreatic cancer rises by 8% with 100 mg/day of cholesterol intake. [summary RR = 1.08, 95% CI = 1.04-1.13]. In conclusion, our analysis suggests that a high intake of cholesterol might increase the risk of pancreatic cancer, especially in America. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/25649888/Association_between_cholesterol_intake_and_pancreatic_cancer_risk:_evidence_from_a_meta_analysis_ L2 - http://dx.doi.org/10.1038/srep08243 DB - PRIME DP - Unbound Medicine ER -