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Quantification of 18F-florbetapir PET: comparison of two analysis methods.
Eur J Nucl Med Mol Imaging 2015; 42(5):725-32EJ

Abstract

PURPOSE

(18)F-Florbetapir positron emission tomography (PET) can be used to image amyloid burden in the human brain. A previously developed research method has been shown to have a high test-retest reliability and good correlation between standardized uptake value ratio (SUVR) and amyloid burden at autopsy. The goal of this study was to determine how well SUVRs computed using the research method could be reproduced using an automatic quantification method, developed for clinical use.

METHODS

Two methods for the quantitative analysis of (18)F-florbetapir PET were compared in a diverse clinical population of 604 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and in a group of 74 younger healthy controls (YHC). Cortex to cerebellum SUVRs were calculated using the research method, which is based on SPM, yielding 'research SUVRs', and using syngo.PET Amyloid Plaque, yielding 'sPAP SUVRs'.

RESULTS

Mean cortical SUVRs calculated using the two methods for the 678 subjects were correlated (r = 0.99). Linear regression of sPAP SUVRs on research SUVRs was used to convert the research method SUVR threshold for florbetapir positivity of 1.10 to a corresponding threshold of 1.12 for sPAP. Using the corresponding thresholds, categorization of SUVR values were in agreement between research and sPAP SUVRs for 96.3 % of the ADNI images. SUVRs for all YHC were below the corresponding thresholds.

CONCLUSION

Automatic florbetapir PET quantification using sPAP yielded cortex to cerebellum SUVRs which were correlated and in good agreement with the well-established research method. The research SUVR threshold for florbetapir positivity was reliably converted to a corresponding threshold for sPAP SUVRs.

Authors+Show Affiliations

Siemens Molecular Imaging, Oxford, UK, chloe.hutton@siemens.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25652817

Citation

Hutton, Chloe, et al. "Quantification of 18F-florbetapir PET: Comparison of Two Analysis Methods." European Journal of Nuclear Medicine and Molecular Imaging, vol. 42, no. 5, 2015, pp. 725-32.
Hutton C, Declerck J, Mintun MA, et al. Quantification of 18F-florbetapir PET: comparison of two analysis methods. Eur J Nucl Med Mol Imaging. 2015;42(5):725-32.
Hutton, C., Declerck, J., Mintun, M. A., Pontecorvo, M. J., Devous, M. D., & Joshi, A. D. (2015). Quantification of 18F-florbetapir PET: comparison of two analysis methods. European Journal of Nuclear Medicine and Molecular Imaging, 42(5), pp. 725-32. doi:10.1007/s00259-015-2988-7.
Hutton C, et al. Quantification of 18F-florbetapir PET: Comparison of Two Analysis Methods. Eur J Nucl Med Mol Imaging. 2015;42(5):725-32. PubMed PMID: 25652817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of 18F-florbetapir PET: comparison of two analysis methods. AU - Hutton,Chloe, AU - Declerck,Jerome, AU - Mintun,Mark A, AU - Pontecorvo,Michael J, AU - Devous,Michael D,Sr AU - Joshi,Abhinay D, AU - ,, Y1 - 2015/02/05/ PY - 2014/09/26/received PY - 2015/01/05/accepted PY - 2015/2/6/entrez PY - 2015/2/6/pubmed PY - 2015/12/15/medline SP - 725 EP - 32 JF - European journal of nuclear medicine and molecular imaging JO - Eur. J. Nucl. Med. Mol. Imaging VL - 42 IS - 5 N2 - PURPOSE: (18)F-Florbetapir positron emission tomography (PET) can be used to image amyloid burden in the human brain. A previously developed research method has been shown to have a high test-retest reliability and good correlation between standardized uptake value ratio (SUVR) and amyloid burden at autopsy. The goal of this study was to determine how well SUVRs computed using the research method could be reproduced using an automatic quantification method, developed for clinical use. METHODS: Two methods for the quantitative analysis of (18)F-florbetapir PET were compared in a diverse clinical population of 604 subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and in a group of 74 younger healthy controls (YHC). Cortex to cerebellum SUVRs were calculated using the research method, which is based on SPM, yielding 'research SUVRs', and using syngo.PET Amyloid Plaque, yielding 'sPAP SUVRs'. RESULTS: Mean cortical SUVRs calculated using the two methods for the 678 subjects were correlated (r = 0.99). Linear regression of sPAP SUVRs on research SUVRs was used to convert the research method SUVR threshold for florbetapir positivity of 1.10 to a corresponding threshold of 1.12 for sPAP. Using the corresponding thresholds, categorization of SUVR values were in agreement between research and sPAP SUVRs for 96.3 % of the ADNI images. SUVRs for all YHC were below the corresponding thresholds. CONCLUSION: Automatic florbetapir PET quantification using sPAP yielded cortex to cerebellum SUVRs which were correlated and in good agreement with the well-established research method. The research SUVR threshold for florbetapir positivity was reliably converted to a corresponding threshold for sPAP SUVRs. SN - 1619-7089 UR - https://www.unboundmedicine.com/medline/citation/25652817/Quantification_of_18F_florbetapir_PET:_comparison_of_two_analysis_methods_ L2 - https://dx.doi.org/10.1007/s00259-015-2988-7 DB - PRIME DP - Unbound Medicine ER -