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Efficacy and safety of diphenylcyclopropenone alone or in combination with anthralin in the treatment of chronic extensive alopecia areata: a retrospective case series.
J Am Acad Dermatol. 2015 Apr; 72(4):640-50.JA

Abstract

BACKGROUND

Some patients with chronic extensive alopecia areata (AA) may be refractory to topical immunotherapy. Combination therapy is recommended for such patients. Efficacy and safety of a combination therapy with diphenylcyclopropenone (DPCP) and anthralin in chronic extensive AA is unknown.

OBJECTIVE

We sought to determine whether the combination therapy of DPCP and anthralin is superior to DPCP alone in chronic extensive AA.

METHODS

We retrospectively analyzed the efficacy, side effects, and relapse rates of DPCP (alone or with anthralin) in chronic extensive AA.

RESULTS

A total of 47 patients (22 were treated only with DPCP, and 25 with DPCP and anthralin for at least 30 weeks) were evaluated. Complete hair regrowth was observed in 36.4% and 72% of the patients who received DPCP and combination therapy, respectively (P = .01). Hair regrowth duration was shorter with combination therapy (P = .01). Regrowth rates of the eyebrows, eyelashes, and beard in patients on combination therapy were higher than those in patients on DPCP (P = .01). Side effects such as folliculitis, hyperpigmentation, and staining of skin, hair, and clothes were more common in combination therapy group.

LIMITATIONS

The retrospective design and small number of patients are limitations.

CONCLUSION

Combination therapy with DPCP and anthralin is superior to DPCP alone in chronic extensive AA.

Authors+Show Affiliations

Department of Dermatology, Başkent University Faculty of Medicine, Adana Hospital, Turkey. Electronic address: sivandr@hotmail.com.Department of Dermatology, Başkent University Faculty of Medicine, Ankara Hospital, Turkey.Department of Dermatology, Başkent University Faculty of Medicine, Adana Hospital, Turkey.Department of Dermatology, Başkent University Faculty of Medicine, Ankara Hospital, Turkey.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25653027

Citation

Durdu, Murat, et al. "Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination With Anthralin in the Treatment of Chronic Extensive Alopecia Areata: a Retrospective Case Series." Journal of the American Academy of Dermatology, vol. 72, no. 4, 2015, pp. 640-50.
Durdu M, Özcan D, Baba M, et al. Efficacy and safety of diphenylcyclopropenone alone or in combination with anthralin in the treatment of chronic extensive alopecia areata: a retrospective case series. J Am Acad Dermatol. 2015;72(4):640-50.
Durdu, M., Özcan, D., Baba, M., & Seçkin, D. (2015). Efficacy and safety of diphenylcyclopropenone alone or in combination with anthralin in the treatment of chronic extensive alopecia areata: a retrospective case series. Journal of the American Academy of Dermatology, 72(4), 640-50. https://doi.org/10.1016/j.jaad.2015.01.008
Durdu M, et al. Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination With Anthralin in the Treatment of Chronic Extensive Alopecia Areata: a Retrospective Case Series. J Am Acad Dermatol. 2015;72(4):640-50. PubMed PMID: 25653027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of diphenylcyclopropenone alone or in combination with anthralin in the treatment of chronic extensive alopecia areata: a retrospective case series. AU - Durdu,Murat, AU - Özcan,Deren, AU - Baba,Mete, AU - Seçkin,Deniz, Y1 - 2015/02/01/ PY - 2014/12/01/received PY - 2015/01/06/revised PY - 2015/01/07/accepted PY - 2015/2/6/entrez PY - 2015/2/6/pubmed PY - 2015/5/20/medline KW - adverse effects KW - alopecia areata KW - alopecia totalis KW - alopecia universalis KW - anthralin KW - cignolin KW - diphencyprone KW - diphenylcyclopropenone KW - dithranol KW - folliculitis SP - 640 EP - 50 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 72 IS - 4 N2 - BACKGROUND: Some patients with chronic extensive alopecia areata (AA) may be refractory to topical immunotherapy. Combination therapy is recommended for such patients. Efficacy and safety of a combination therapy with diphenylcyclopropenone (DPCP) and anthralin in chronic extensive AA is unknown. OBJECTIVE: We sought to determine whether the combination therapy of DPCP and anthralin is superior to DPCP alone in chronic extensive AA. METHODS: We retrospectively analyzed the efficacy, side effects, and relapse rates of DPCP (alone or with anthralin) in chronic extensive AA. RESULTS: A total of 47 patients (22 were treated only with DPCP, and 25 with DPCP and anthralin for at least 30 weeks) were evaluated. Complete hair regrowth was observed in 36.4% and 72% of the patients who received DPCP and combination therapy, respectively (P = .01). Hair regrowth duration was shorter with combination therapy (P = .01). Regrowth rates of the eyebrows, eyelashes, and beard in patients on combination therapy were higher than those in patients on DPCP (P = .01). Side effects such as folliculitis, hyperpigmentation, and staining of skin, hair, and clothes were more common in combination therapy group. LIMITATIONS: The retrospective design and small number of patients are limitations. CONCLUSION: Combination therapy with DPCP and anthralin is superior to DPCP alone in chronic extensive AA. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/25653027/Efficacy_and_safety_of_diphenylcyclopropenone_alone_or_in_combination_with_anthralin_in_the_treatment_of_chronic_extensive_alopecia_areata:_a_retrospective_case_series_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(15)00039-0 DB - PRIME DP - Unbound Medicine ER -