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Predisposition to familial osteoarthrosis linked to type II collagen gene.
Lancet. 1989 Apr 29; 1(8644):924-7.Lct

Abstract

The genetic background of two families, in whom a predisposition to primary osteoarthrosis is inherited as a dominant trait, was investigated. Use of restriction fragment length polymorphisms within and around the type II collagen gene on chromosome 12 revealed a linkage between this cartilage-specific gene and primary osteoarthrosis.

Authors+Show Affiliations

Palotie A
Laboratory of Molecular Genetics, National Public Health Institute, Helsinki, Finland.
Väisänen P
No affiliation info available
Ott J
No affiliation info available
Ryhänen L
No affiliation info available
Elima K
No affiliation info available
Vikkula M
No affiliation info available
Cheah K
No affiliation info available
Vuorio E
No affiliation info available
Peltonen L
No affiliation info available

MeSH

AdultAge FactorsChromosomes, Human, Pair 12CollagenDNADisease SusceptibilityFemaleGenes, DominantGenetic LinkageHumansMaleMiddle AgedMutationOsteoarthritisPedigreePolymorphism, Restriction Fragment LengthRadiographySeverity of Illness Index

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2565419

Citation

Palotie, A, et al. "Predisposition to Familial Osteoarthrosis Linked to Type II Collagen Gene." Lancet (London, England), vol. 1, no. 8644, 1989, pp. 924-7.
Palotie A, Väisänen P, Ott J, et al. Predisposition to familial osteoarthrosis linked to type II collagen gene. Lancet. 1989;1(8644):924-7.
Palotie, A., Väisänen, P., Ott, J., Ryhänen, L., Elima, K., Vikkula, M., Cheah, K., Vuorio, E., & Peltonen, L. (1989). Predisposition to familial osteoarthrosis linked to type II collagen gene. Lancet (London, England), 1(8644), 924-7.
Palotie A, et al. Predisposition to Familial Osteoarthrosis Linked to Type II Collagen Gene. Lancet. 1989 Apr 29;1(8644):924-7. PubMed PMID: 2565419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predisposition to familial osteoarthrosis linked to type II collagen gene. AU - Palotie,A, AU - Väisänen,P, AU - Ott,J, AU - Ryhänen,L, AU - Elima,K, AU - Vikkula,M, AU - Cheah,K, AU - Vuorio,E, AU - Peltonen,L, PY - 1989/4/29/pubmed PY - 1989/4/29/medline PY - 1989/4/29/entrez SP - 924 EP - 7 JF - Lancet (London, England) JO - Lancet VL - 1 IS - 8644 N2 - The genetic background of two families, in whom a predisposition to primary osteoarthrosis is inherited as a dominant trait, was investigated. Use of restriction fragment length polymorphisms within and around the type II collagen gene on chromosome 12 revealed a linkage between this cartilage-specific gene and primary osteoarthrosis. SN - 0140-6736 UR - https://www.unboundmedicine.com/medline/citation/2565419/Predisposition_to_familial_osteoarthrosis_linked_to_type_II_collagen_gene_ DB - PRIME DP - Unbound Medicine ER -