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Biology of subjective cognitive complaint amongst geriatric patients: vitamin D involvement.

Abstract

BACKGROUND

Insufficiency in vitamin D, a neurosteroid hormone, is associated with cognitive decline in older adults. The impact on the subjective perception of cognitive decline has not yet been examined. The objective of this cross-sectional hospital-based study was to determine whether vitamin D insufficiency was associated with subjective cognitive complaint amongst geriatric patients.

METHODS

Ninety-nine consecutive Caucasian in- and outpatients recruited in the 'Cognition and LIPophilic vitamins' (CLIP) study, who had no advanced cognitive disorders (i.e., Mini-Mental State Examination score≥20) and who took no vitamin D supplements, were categorized into 2 groups based on vitamin D insufficiency (i.e., serum 25-hydroxyvitamin D≥75 nmol/L). Subjective cognitive complaint was examined using the Memory Complaint Questionnaire (MAC-Q; score 0-30, best). MAC-Q score<15 out of 30 defined severe cognitive complaint. Age, gender, body mass index, education level, comorbidity burden, functional autonomy, mood, and serum concentrations of parathyroid hormone, calcium, thyroid-stimulating hormone and vitamin B12, and estimated glomerular filtration rate were used as potential confounders.

RESULTS

Compared to participants with serum 25OHD>75 nmol/L, those with vitamin D insufficiency (n=89) had a lower mean MAC-Q score (14.9±2.9 versus 17.1±1.6, P=0.02) and more often a MAC-Q score<15 (52.8% versus 10.0%, P=0.01). Vitamin D insufficiency was inversely associated with the MAC-Q score (adjusted β=-2.84, P=0.03), and positively associated with severe cognitive complaint (adjusted OR=10.07, P=0.03).

CONCLUSION

Vitamin D insufficiency was associated with subjective cognitive complaint in the studied cohort of geriatric patients.

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  • Authors+Show Affiliations

    , , , , ,

    Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, 49933 Angers Cedex 9, France. CeAnnweiler@chu-angers.fr.

    Source

    Current Alzheimer research 12:2 2015 pg 173-8

    MeSH

    Aged, 80 and over
    Aging
    Cognition Disorders
    Cohort Studies
    Comorbidity
    Cross-Sectional Studies
    European Continental Ancestry Group
    Female
    Humans
    Male
    Memory
    Surveys and Questionnaires
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Observational Study

    Language

    eng

    PubMed ID

    25654506

    Citation

    Tot Babberich, Elena De Neree, et al. "Biology of Subjective Cognitive Complaint Amongst Geriatric Patients: Vitamin D Involvement." Current Alzheimer Research, vol. 12, no. 2, 2015, pp. 173-8.
    Tot Babberich Ede N, Gourdeau C, Pointel S, et al. Biology of subjective cognitive complaint amongst geriatric patients: vitamin D involvement. Curr Alzheimer Res. 2015;12(2):173-8.
    Tot Babberich, E. d. e. . N., Gourdeau, C., Pointel, S., Lemarchant, B., Beauchet, O., & Annweiler, C. (2015). Biology of subjective cognitive complaint amongst geriatric patients: vitamin D involvement. Current Alzheimer Research, 12(2), pp. 173-8.
    Tot Babberich Ede N, et al. Biology of Subjective Cognitive Complaint Amongst Geriatric Patients: Vitamin D Involvement. Curr Alzheimer Res. 2015;12(2):173-8. PubMed PMID: 25654506.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Biology of subjective cognitive complaint amongst geriatric patients: vitamin D involvement. AU - Tot Babberich,Elena De Neree, AU - Gourdeau,Clemence, AU - Pointel,Simon, AU - Lemarchant,Bruno, AU - Beauchet,Olivier, AU - Annweiler,Cedric, PY - 2014/09/12/received PY - 2014/11/13/revised PY - 2014/11/14/accepted PY - 2015/2/6/entrez PY - 2015/2/6/pubmed PY - 2015/12/17/medline SP - 173 EP - 8 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 12 IS - 2 N2 - BACKGROUND: Insufficiency in vitamin D, a neurosteroid hormone, is associated with cognitive decline in older adults. The impact on the subjective perception of cognitive decline has not yet been examined. The objective of this cross-sectional hospital-based study was to determine whether vitamin D insufficiency was associated with subjective cognitive complaint amongst geriatric patients. METHODS: Ninety-nine consecutive Caucasian in- and outpatients recruited in the 'Cognition and LIPophilic vitamins' (CLIP) study, who had no advanced cognitive disorders (i.e., Mini-Mental State Examination score≥20) and who took no vitamin D supplements, were categorized into 2 groups based on vitamin D insufficiency (i.e., serum 25-hydroxyvitamin D≥75 nmol/L). Subjective cognitive complaint was examined using the Memory Complaint Questionnaire (MAC-Q; score 0-30, best). MAC-Q score<15 out of 30 defined severe cognitive complaint. Age, gender, body mass index, education level, comorbidity burden, functional autonomy, mood, and serum concentrations of parathyroid hormone, calcium, thyroid-stimulating hormone and vitamin B12, and estimated glomerular filtration rate were used as potential confounders. RESULTS: Compared to participants with serum 25OHD>75 nmol/L, those with vitamin D insufficiency (n=89) had a lower mean MAC-Q score (14.9±2.9 versus 17.1±1.6, P=0.02) and more often a MAC-Q score<15 (52.8% versus 10.0%, P=0.01). Vitamin D insufficiency was inversely associated with the MAC-Q score (adjusted β=-2.84, P=0.03), and positively associated with severe cognitive complaint (adjusted OR=10.07, P=0.03). CONCLUSION: Vitamin D insufficiency was associated with subjective cognitive complaint in the studied cohort of geriatric patients. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/25654506/Biology_of_subjective_cognitive_complaint_amongst_geriatric_patients:_vitamin_D_involvement_ L2 - http://www.eurekaselect.com/128204/article DB - PRIME DP - Unbound Medicine ER -