Tags

Type your tag names separated by a space and hit enter

Biology of subjective cognitive complaint amongst geriatric patients: vitamin D involvement.
Curr Alzheimer Res. 2015; 12(2):173-8.CA

Abstract

BACKGROUND

Insufficiency in vitamin D, a neurosteroid hormone, is associated with cognitive decline in older adults. The impact on the subjective perception of cognitive decline has not yet been examined. The objective of this cross-sectional hospital-based study was to determine whether vitamin D insufficiency was associated with subjective cognitive complaint amongst geriatric patients.

METHODS

Ninety-nine consecutive Caucasian in- and outpatients recruited in the 'Cognition and LIPophilic vitamins' (CLIP) study, who had no advanced cognitive disorders (i.e., Mini-Mental State Examination score≥20) and who took no vitamin D supplements, were categorized into 2 groups based on vitamin D insufficiency (i.e., serum 25-hydroxyvitamin D≥75 nmol/L). Subjective cognitive complaint was examined using the Memory Complaint Questionnaire (MAC-Q; score 0-30, best). MAC-Q score<15 out of 30 defined severe cognitive complaint. Age, gender, body mass index, education level, comorbidity burden, functional autonomy, mood, and serum concentrations of parathyroid hormone, calcium, thyroid-stimulating hormone and vitamin B12, and estimated glomerular filtration rate were used as potential confounders.

RESULTS

Compared to participants with serum 25OHD>75 nmol/L, those with vitamin D insufficiency (n=89) had a lower mean MAC-Q score (14.9±2.9 versus 17.1±1.6, P=0.02) and more often a MAC-Q score<15 (52.8% versus 10.0%, P=0.01). Vitamin D insufficiency was inversely associated with the MAC-Q score (adjusted β=-2.84, P=0.03), and positively associated with severe cognitive complaint (adjusted OR=10.07, P=0.03).

CONCLUSION

Vitamin D insufficiency was associated with subjective cognitive complaint in the studied cohort of geriatric patients.

Authors+Show Affiliations

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableDepartment of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, 49933 Angers Cedex 9, France. CeAnnweiler@chu-angers.fr.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

25654506

Citation

Tot Babberich, Elena De Neree, et al. "Biology of Subjective Cognitive Complaint Amongst Geriatric Patients: Vitamin D Involvement." Current Alzheimer Research, vol. 12, no. 2, 2015, pp. 173-8.
Tot Babberich Ede N, Gourdeau C, Pointel S, et al. Biology of subjective cognitive complaint amongst geriatric patients: vitamin D involvement. Curr Alzheimer Res. 2015;12(2):173-8.
Tot Babberich, E. d. e. . N., Gourdeau, C., Pointel, S., Lemarchant, B., Beauchet, O., & Annweiler, C. (2015). Biology of subjective cognitive complaint amongst geriatric patients: vitamin D involvement. Current Alzheimer Research, 12(2), 173-8.
Tot Babberich Ede N, et al. Biology of Subjective Cognitive Complaint Amongst Geriatric Patients: Vitamin D Involvement. Curr Alzheimer Res. 2015;12(2):173-8. PubMed PMID: 25654506.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biology of subjective cognitive complaint amongst geriatric patients: vitamin D involvement. AU - Tot Babberich,Elena De Neree, AU - Gourdeau,Clemence, AU - Pointel,Simon, AU - Lemarchant,Bruno, AU - Beauchet,Olivier, AU - Annweiler,Cedric, PY - 2014/09/12/received PY - 2014/11/13/revised PY - 2014/11/14/accepted PY - 2015/2/6/entrez PY - 2015/2/6/pubmed PY - 2015/12/17/medline SP - 173 EP - 8 JF - Current Alzheimer research JO - Curr Alzheimer Res VL - 12 IS - 2 N2 - BACKGROUND: Insufficiency in vitamin D, a neurosteroid hormone, is associated with cognitive decline in older adults. The impact on the subjective perception of cognitive decline has not yet been examined. The objective of this cross-sectional hospital-based study was to determine whether vitamin D insufficiency was associated with subjective cognitive complaint amongst geriatric patients. METHODS: Ninety-nine consecutive Caucasian in- and outpatients recruited in the 'Cognition and LIPophilic vitamins' (CLIP) study, who had no advanced cognitive disorders (i.e., Mini-Mental State Examination score≥20) and who took no vitamin D supplements, were categorized into 2 groups based on vitamin D insufficiency (i.e., serum 25-hydroxyvitamin D≥75 nmol/L). Subjective cognitive complaint was examined using the Memory Complaint Questionnaire (MAC-Q; score 0-30, best). MAC-Q score<15 out of 30 defined severe cognitive complaint. Age, gender, body mass index, education level, comorbidity burden, functional autonomy, mood, and serum concentrations of parathyroid hormone, calcium, thyroid-stimulating hormone and vitamin B12, and estimated glomerular filtration rate were used as potential confounders. RESULTS: Compared to participants with serum 25OHD>75 nmol/L, those with vitamin D insufficiency (n=89) had a lower mean MAC-Q score (14.9±2.9 versus 17.1±1.6, P=0.02) and more often a MAC-Q score<15 (52.8% versus 10.0%, P=0.01). Vitamin D insufficiency was inversely associated with the MAC-Q score (adjusted β=-2.84, P=0.03), and positively associated with severe cognitive complaint (adjusted OR=10.07, P=0.03). CONCLUSION: Vitamin D insufficiency was associated with subjective cognitive complaint in the studied cohort of geriatric patients. SN - 1875-5828 UR - https://www.unboundmedicine.com/medline/citation/25654506/Biology_of_subjective_cognitive_complaint_amongst_geriatric_patients:_vitamin_D_involvement_ L2 - http://www.eurekaselect.com/128204/article DB - PRIME DP - Unbound Medicine ER -