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Impulse oscillometry in adults with bronchiectasis.
Ann Am Thorac Soc 2015; 12(5):657-65AA

Abstract

RATIONALE

The usefulness of impulse oscillometry (IOS) in bronchiectasis has not been systematically investigated.

OBJECTIVES

To determine the usefulness of IOS parameters and their correlation with radiology, disease severity, sputum bacteriology, and spirometry, and to compare the changes in IOS parameters during exacerbations and convalescence of bronchiectasis.

METHODS

We recruited 100 patients with bronchiectasis and 28 healthy subjects. Receiver operating characteristic curve was plotted to analyze the diagnostic performance of IOS parameters. Chest high-resolution computed tomography (HRCT), Bronchiectasis Severity Index (BSI) assessment, sputum culture, and spirometry were performed. Correlation between IOS parameters and clinical indices was determined using the Spearman model. Changes in IOS parameters, compared with spirometry, during exacerbation were assessed in 16 patients with bronchiectasis.

MEASUREMENTS AND MAIN RESULTS

IOS parameters (in particular, resonant frequency) could discriminate patients with bronchiectasis from healthy subjects. Higher levels of IOS parameters were associated with Pseudomonas aeruginosa infection, dyshomogeneity, higher BSI and HRCT score, more bronchiectatic lobes, and cystic bronchiectasis (all P < 0.05). All IOS parameters but lung resistance at 5 Hz were positively correlated with the duration of bronchiectasis symptoms, number of bronchiectatic lobes, HRCT total scores, and BSI (all P < 0.05), but not sputum bacterial density (P > 0.05). IOS parameters, but not spirometric parameters, were not statistically different between peripheral and peripheral plus central segment bronchiectasis (all P > 0.05). Increased frequency dependence (higher resonance frequency or reactance area) was more likely to be associated with lower HRCT scores (≤5) than FEV1. Compared with FEV1, any single IOS parameter being abnormal was more common in mild bronchiectasis, particularly in patients with HRCT score of 5 or lower. IOS parameters were not statistically different from baseline to exacerbations and convalescence (all P > 0.05).

CONCLUSIONS

IOS parameters correlate with clinical indices and could reflect peripheral airway abnormality. An increased number of aberrant IOS parameters signals poorer clinical conditions. Increased frequency dependence might be a sensitive marker of mild bronchiectasis. Any single IOS parameter being abnormal sensitively reflects mild bronchiectasis. IOS parameters do not change significantly during bronchiectasis exacerbations. Clinical Trial registered with www.clinicaltrials.gov (NCT01761214).

Authors+Show Affiliations

1 State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25654540

Citation

Guan, Wei-jie, et al. "Impulse Oscillometry in Adults With Bronchiectasis." Annals of the American Thoracic Society, vol. 12, no. 5, 2015, pp. 657-65.
Guan WJ, Gao YH, Xu G, et al. Impulse oscillometry in adults with bronchiectasis. Ann Am Thorac Soc. 2015;12(5):657-65.
Guan, W. J., Gao, Y. H., Xu, G., Lin, Z. Y., Tang, Y., Li, H. M., ... Zhong, N. S. (2015). Impulse oscillometry in adults with bronchiectasis. Annals of the American Thoracic Society, 12(5), pp. 657-65. doi:10.1513/AnnalsATS.201406-280OC.
Guan WJ, et al. Impulse Oscillometry in Adults With Bronchiectasis. Ann Am Thorac Soc. 2015;12(5):657-65. PubMed PMID: 25654540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impulse oscillometry in adults with bronchiectasis. AU - Guan,Wei-jie, AU - Gao,Yong-hua, AU - Xu,Gang, AU - Lin,Zhi-ya, AU - Tang,Yan, AU - Li,Hui-min, AU - Lin,Zhi-min, AU - Zheng,Jin-ping, AU - Chen,Rong-chang, AU - Zhong,Nan-shan, PY - 2015/2/6/entrez PY - 2015/2/6/pubmed PY - 2016/2/3/medline KW - acute exacerbation KW - bacteriology KW - bronchiectasis KW - convalescence KW - impulse oscillometry SP - 657 EP - 65 JF - Annals of the American Thoracic Society JO - Ann Am Thorac Soc VL - 12 IS - 5 N2 - RATIONALE: The usefulness of impulse oscillometry (IOS) in bronchiectasis has not been systematically investigated. OBJECTIVES: To determine the usefulness of IOS parameters and their correlation with radiology, disease severity, sputum bacteriology, and spirometry, and to compare the changes in IOS parameters during exacerbations and convalescence of bronchiectasis. METHODS: We recruited 100 patients with bronchiectasis and 28 healthy subjects. Receiver operating characteristic curve was plotted to analyze the diagnostic performance of IOS parameters. Chest high-resolution computed tomography (HRCT), Bronchiectasis Severity Index (BSI) assessment, sputum culture, and spirometry were performed. Correlation between IOS parameters and clinical indices was determined using the Spearman model. Changes in IOS parameters, compared with spirometry, during exacerbation were assessed in 16 patients with bronchiectasis. MEASUREMENTS AND MAIN RESULTS: IOS parameters (in particular, resonant frequency) could discriminate patients with bronchiectasis from healthy subjects. Higher levels of IOS parameters were associated with Pseudomonas aeruginosa infection, dyshomogeneity, higher BSI and HRCT score, more bronchiectatic lobes, and cystic bronchiectasis (all P < 0.05). All IOS parameters but lung resistance at 5 Hz were positively correlated with the duration of bronchiectasis symptoms, number of bronchiectatic lobes, HRCT total scores, and BSI (all P < 0.05), but not sputum bacterial density (P > 0.05). IOS parameters, but not spirometric parameters, were not statistically different between peripheral and peripheral plus central segment bronchiectasis (all P > 0.05). Increased frequency dependence (higher resonance frequency or reactance area) was more likely to be associated with lower HRCT scores (≤5) than FEV1. Compared with FEV1, any single IOS parameter being abnormal was more common in mild bronchiectasis, particularly in patients with HRCT score of 5 or lower. IOS parameters were not statistically different from baseline to exacerbations and convalescence (all P > 0.05). CONCLUSIONS: IOS parameters correlate with clinical indices and could reflect peripheral airway abnormality. An increased number of aberrant IOS parameters signals poorer clinical conditions. Increased frequency dependence might be a sensitive marker of mild bronchiectasis. Any single IOS parameter being abnormal sensitively reflects mild bronchiectasis. IOS parameters do not change significantly during bronchiectasis exacerbations. Clinical Trial registered with www.clinicaltrials.gov (NCT01761214). SN - 2325-6621 UR - https://www.unboundmedicine.com/medline/citation/25654540/Impulse_oscillometry_in_adults_with_bronchiectasis_ L2 - http://www.atsjournals.org/doi/full/10.1513/AnnalsATS.201406-280OC?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -