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Long-term haloperidol treatment decreases somatostatin binding in rat brain.
Neuropeptides. 1989 Apr; 13(3):157-63.N

Abstract

The effects of short and long-term haloperidol treatment on somatostatin concentration and specific binding in rat cerebral cortex and hippocampus were examined using the binding ligand 125I-Tyr1-somatostatin. Haloperidol treatment did not affect the concentration of somatostatin-like immunoreactivity in the two brain areas. Nevertheless, long-term, and not short-term, haloperidol treatment decreased the number of somatostatin receptors in the cerebral cortex and hippocampus. No significant differences in the apparent binding affinity values were seen after haloperidol treatment. When added at the time of the binding assay haloperidol 34.2 microM produced a 42% and 27% decrease in cerebrocortical and hippocampal membrane somatostatin receptors respectively.

Authors+Show Affiliations

Perez-Oso E
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Alcala de Henares, Madrid, Spain.
Colas B
No affiliation info available
Lopez-Ruiz MP
No affiliation info available
Arilla E
No affiliation info available

MeSH

AnimalsCerebral CortexHaloperidolHippocampusMaleRadioimmunoassayRatsRats, Inbred StrainsReceptors, NeurotransmitterReceptors, SomatostatinSomatostatinTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2565556

Citation

Perez-Oso, E, et al. "Long-term Haloperidol Treatment Decreases Somatostatin Binding in Rat Brain." Neuropeptides, vol. 13, no. 3, 1989, pp. 157-63.
Perez-Oso E, Colas B, Lopez-Ruiz MP, et al. Long-term haloperidol treatment decreases somatostatin binding in rat brain. Neuropeptides. 1989;13(3):157-63.
Perez-Oso, E., Colas, B., Lopez-Ruiz, M. P., & Arilla, E. (1989). Long-term haloperidol treatment decreases somatostatin binding in rat brain. Neuropeptides, 13(3), 157-63.
Perez-Oso E, et al. Long-term Haloperidol Treatment Decreases Somatostatin Binding in Rat Brain. Neuropeptides. 1989;13(3):157-63. PubMed PMID: 2565556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term haloperidol treatment decreases somatostatin binding in rat brain. AU - Perez-Oso,E, AU - Colas,B, AU - Lopez-Ruiz,M P, AU - Arilla,E, PY - 1989/4/1/pubmed PY - 1989/4/1/medline PY - 1989/4/1/entrez SP - 157 EP - 63 JF - Neuropeptides JO - Neuropeptides VL - 13 IS - 3 N2 - The effects of short and long-term haloperidol treatment on somatostatin concentration and specific binding in rat cerebral cortex and hippocampus were examined using the binding ligand 125I-Tyr1-somatostatin. Haloperidol treatment did not affect the concentration of somatostatin-like immunoreactivity in the two brain areas. Nevertheless, long-term, and not short-term, haloperidol treatment decreased the number of somatostatin receptors in the cerebral cortex and hippocampus. No significant differences in the apparent binding affinity values were seen after haloperidol treatment. When added at the time of the binding assay haloperidol 34.2 microM produced a 42% and 27% decrease in cerebrocortical and hippocampal membrane somatostatin receptors respectively. SN - 0143-4179 UR - https://www.unboundmedicine.com/medline/citation/2565556/Long_term_haloperidol_treatment_decreases_somatostatin_binding_in_rat_brain_ DB - PRIME DP - Unbound Medicine ER -