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Middle East respiratory syndrome: An emerging coronavirus infection tracked by the crowd.
Virus Res. 2015 Apr 16; 202:60-88.VR

Abstract

In 2012 in Jordan, infection by a novel coronavirus (CoV) caused the first known cases of Middle East respiratory syndrome (MERS). MERS-CoV sequences have since been found in a bat and the virus appears to be enzootic among dromedary camels across the Arabian Peninsula and in parts of Africa. The majority of human cases have occurred in the Kingdom of Saudi Arabia (KSA). In humans, the etiologic agent, MERS-CoV, has been detected in severe, mild and influenza-like illness and in those without any obvious signs or symptoms of disease. MERS is often a lower respiratory tract disease associated with fever, cough, breathing difficulties, pneumonia that can progress to acute respiratory distress syndrome, multiorgan failure and death among more than a third of those infected. Severe disease is usually found in older males and comorbidities are frequently present in cases of MERS. Compared to SARS, MERS progresses more rapidly to respiratory failure and acute kidney injury, is more often observed as severe disease in patients with underlying illnesses and is more often fatal. MERS-CoV has a broader tropism than SARS-CoV, rapidly triggers cellular damage, employs a different receptor and induces a delayed proinflammatory response in cells. Most human cases have been linked to lapses in infection prevention and control in healthcare settings, with a fifth of virus detections reported among healthcare workers. This review sets out what is currently known about MERS and the MERS-CoV, summarises the new phenomenon of crowd-sourced epidemiology and lists some of the many questions that remain unanswered, nearly three years after the first reported case.

Authors+Show Affiliations

Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Australia. Electronic address: ian.mackay@uq.edu.au.Queensland Paediatric Infectious Diseases Laboratory, Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25656066

Citation

Mackay, Ian M., and Katherine E. Arden. "Middle East Respiratory Syndrome: an Emerging Coronavirus Infection Tracked By the Crowd." Virus Research, vol. 202, 2015, pp. 60-88.
Mackay IM, Arden KE. Middle East respiratory syndrome: An emerging coronavirus infection tracked by the crowd. Virus Res. 2015;202:60-88.
Mackay, I. M., & Arden, K. E. (2015). Middle East respiratory syndrome: An emerging coronavirus infection tracked by the crowd. Virus Research, 202, 60-88. https://doi.org/10.1016/j.virusres.2015.01.021
Mackay IM, Arden KE. Middle East Respiratory Syndrome: an Emerging Coronavirus Infection Tracked By the Crowd. Virus Res. 2015 Apr 16;202:60-88. PubMed PMID: 25656066.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Middle East respiratory syndrome: An emerging coronavirus infection tracked by the crowd. AU - Mackay,Ian M, AU - Arden,Katherine E, Y1 - 2015/02/02/ PY - 2014/06/09/received PY - 2015/01/22/revised PY - 2015/01/23/accepted PY - 2015/2/7/entrez PY - 2015/2/7/pubmed PY - 2016/2/18/medline KW - Camel KW - Emerging infectious disease KW - Healthcare worker KW - MERS KW - MERS-CoV KW - Zoonosis SP - 60 EP - 88 JF - Virus research JO - Virus Res VL - 202 N2 - In 2012 in Jordan, infection by a novel coronavirus (CoV) caused the first known cases of Middle East respiratory syndrome (MERS). MERS-CoV sequences have since been found in a bat and the virus appears to be enzootic among dromedary camels across the Arabian Peninsula and in parts of Africa. The majority of human cases have occurred in the Kingdom of Saudi Arabia (KSA). In humans, the etiologic agent, MERS-CoV, has been detected in severe, mild and influenza-like illness and in those without any obvious signs or symptoms of disease. MERS is often a lower respiratory tract disease associated with fever, cough, breathing difficulties, pneumonia that can progress to acute respiratory distress syndrome, multiorgan failure and death among more than a third of those infected. Severe disease is usually found in older males and comorbidities are frequently present in cases of MERS. Compared to SARS, MERS progresses more rapidly to respiratory failure and acute kidney injury, is more often observed as severe disease in patients with underlying illnesses and is more often fatal. MERS-CoV has a broader tropism than SARS-CoV, rapidly triggers cellular damage, employs a different receptor and induces a delayed proinflammatory response in cells. Most human cases have been linked to lapses in infection prevention and control in healthcare settings, with a fifth of virus detections reported among healthcare workers. This review sets out what is currently known about MERS and the MERS-CoV, summarises the new phenomenon of crowd-sourced epidemiology and lists some of the many questions that remain unanswered, nearly three years after the first reported case. SN - 1872-7492 UR - https://www.unboundmedicine.com/medline/citation/25656066/Middle_East_respiratory_syndrome:_An_emerging_coronavirus_infection_tracked_by_the_crowd_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-1702(15)00046-5 DB - PRIME DP - Unbound Medicine ER -