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Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of some butyrophenones.
Z Rechtsmed. 1989; 102(2-3):127-32.ZR

Abstract

A simple and rapid method for isolation of five butyrophenones with Sep-Pak C18 cartridges from human samples, and their wide-bore capillary gas chromatography (GC), are presented. The GC was made by both flame ionization and electron capture detections. The drugs contained in alkaline samples were directly applied to the cartridges and eluted with chloroform/isopropanol (9:1). The recoveries with use of the cartridges were excellent for most drugs in both urine and plasma samples. We can recommend the Sep-Pak C18 cartridges for isolation of butyrophenones because of simplicity and rapidity, and also wide-bore capillary GC because of high sensitivity and low decomposition of drugs during passage through the column.

Authors+Show Affiliations

Seno H
Department of Legal Medicine, Hamamatsu University School of Medicine, Japan.
Suzuki O
No affiliation info available
Kumazawa T
No affiliation info available
Asano M
No affiliation info available

MeSH

Antipsychotic AgentsButyrophenonesChromatography, GasHaloperidolHumansSpiperone

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

2565634

Citation

Seno, H, et al. "Rapid Isolation With Sep-Pak C18 Cartridges and Wide-bore Capillary Gas Chromatography of some Butyrophenones." Zeitschrift Fur Rechtsmedizin. Journal of Legal Medicine, vol. 102, no. 2-3, 1989, pp. 127-32.
Seno H, Suzuki O, Kumazawa T, et al. Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of some butyrophenones. Z Rechtsmed. 1989;102(2-3):127-32.
Seno, H., Suzuki, O., Kumazawa, T., & Asano, M. (1989). Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of some butyrophenones. Zeitschrift Fur Rechtsmedizin. Journal of Legal Medicine, 102(2-3), 127-32.
Seno H, et al. Rapid Isolation With Sep-Pak C18 Cartridges and Wide-bore Capillary Gas Chromatography of some Butyrophenones. Z Rechtsmed. 1989;102(2-3):127-32. PubMed PMID: 2565634.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rapid isolation with Sep-Pak C18 cartridges and wide-bore capillary gas chromatography of some butyrophenones. AU - Seno,H, AU - Suzuki,O, AU - Kumazawa,T, AU - Asano,M, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 127 EP - 32 JF - Zeitschrift fur Rechtsmedizin. Journal of legal medicine JO - Z Rechtsmed VL - 102 IS - 2-3 N2 - A simple and rapid method for isolation of five butyrophenones with Sep-Pak C18 cartridges from human samples, and their wide-bore capillary gas chromatography (GC), are presented. The GC was made by both flame ionization and electron capture detections. The drugs contained in alkaline samples were directly applied to the cartridges and eluted with chloroform/isopropanol (9:1). The recoveries with use of the cartridges were excellent for most drugs in both urine and plasma samples. We can recommend the Sep-Pak C18 cartridges for isolation of butyrophenones because of simplicity and rapidity, and also wide-bore capillary GC because of high sensitivity and low decomposition of drugs during passage through the column. SN - 0044-3433 UR - https://www.unboundmedicine.com/medline/citation/2565634/Rapid_isolation_with_Sep_Pak_C18_cartridges_and_wide_bore_capillary_gas_chromatography_of_some_butyrophenones_ DB - PRIME DP - Unbound Medicine ER -