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Fibronectin changes in eosinophilic meningitis with blood-CSF barrier disruption.
Exp Parasitol. 2015 Apr-May; 151-152:73-9.EP

Abstract

Fibronectin, which is present at relatively low levels in healthy central nervous systems (CNS), shows increased levels in meningitis. In this study, fibronectin processing was correlated with the increased permeability of the blood-cerebrospinal fluid (CSF) barrier as well as with the formation of eosinophil infiltrates in angiostrongyliasis meningitis. The immunohistochemistry results show matrix metalloproteinase-9 (MMP-9) is localized in the choroid plexus epithelium. Coimmunoprecipitation demonstrated fibronectin strongly binds MMP-9. Furthermore, treatment with the MMP-9 inhibitor GM6001 significantly inhibited fibronectin processing, reduced the blood-CSF barrier permeability, and decreased the eosinophil counts. The decreased fibronectin processing in CSF implies decreased cellular invasion of the subarachnoid space across the blood-CSF barrier. Therefore, increased fibronectin processing may be associated with barrier disruption and participate in the extravasation and migration of eosinophils into the CNS during experimental parasitic infection.

Authors+Show Affiliations

Department of Parasitology, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.Department of Anatomy, School of Medicine, Chung-Shan Medical University, Taichung 402, Taiwan.Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.Department of Parasitology, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan.Department of Parasitology, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan; Clinical Laboratory, Chung Shan Medical University Hospital, Taichung 402, Taiwan. Electronic address: shih@csmu.edu.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25660199

Citation

Shyu, Ling-Yuh, et al. "Fibronectin Changes in Eosinophilic Meningitis With blood-CSF Barrier Disruption." Experimental Parasitology, vol. 151-152, 2015, pp. 73-9.
Shyu LY, Hu ME, Chou CH, et al. Fibronectin changes in eosinophilic meningitis with blood-CSF barrier disruption. Exp Parasitol. 2015;151-152:73-9.
Shyu, L. Y., Hu, M. E., Chou, C. H., Chen, K. M., Chiu, P. S., & Lai, S. C. (2015). Fibronectin changes in eosinophilic meningitis with blood-CSF barrier disruption. Experimental Parasitology, 151-152, 73-9. https://doi.org/10.1016/j.exppara.2015.02.002
Shyu LY, et al. Fibronectin Changes in Eosinophilic Meningitis With blood-CSF Barrier Disruption. Exp Parasitol. 2015 Apr-May;151-152:73-9. PubMed PMID: 25660199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fibronectin changes in eosinophilic meningitis with blood-CSF barrier disruption. AU - Shyu,Ling-Yuh, AU - Hu,Ming-E, AU - Chou,Chun-Hui, AU - Chen,Ke-Min, AU - Chiu,Ping-Sung, AU - Lai,Shih-Chan, Y1 - 2015/02/07/ PY - 2014/01/17/received PY - 2015/01/27/revised PY - 2015/02/01/accepted PY - 2015/2/10/entrez PY - 2015/2/11/pubmed PY - 2015/5/16/medline KW - Angiostrongylus cantonensis KW - Evans blue KW - Fibronectin KW - Meningitis SP - 73 EP - 9 JF - Experimental parasitology JO - Exp Parasitol VL - 151-152 N2 - Fibronectin, which is present at relatively low levels in healthy central nervous systems (CNS), shows increased levels in meningitis. In this study, fibronectin processing was correlated with the increased permeability of the blood-cerebrospinal fluid (CSF) barrier as well as with the formation of eosinophil infiltrates in angiostrongyliasis meningitis. The immunohistochemistry results show matrix metalloproteinase-9 (MMP-9) is localized in the choroid plexus epithelium. Coimmunoprecipitation demonstrated fibronectin strongly binds MMP-9. Furthermore, treatment with the MMP-9 inhibitor GM6001 significantly inhibited fibronectin processing, reduced the blood-CSF barrier permeability, and decreased the eosinophil counts. The decreased fibronectin processing in CSF implies decreased cellular invasion of the subarachnoid space across the blood-CSF barrier. Therefore, increased fibronectin processing may be associated with barrier disruption and participate in the extravasation and migration of eosinophils into the CNS during experimental parasitic infection. SN - 1090-2449 UR - https://www.unboundmedicine.com/medline/citation/25660199/Fibronectin_changes_in_eosinophilic_meningitis_with_blood_CSF_barrier_disruption_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4894(15)00033-8 DB - PRIME DP - Unbound Medicine ER -