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The relationship between obesity, low back pain, and lumbar disc degeneration when genetics and the environment are considered: a systematic review of twin studies.
Spine J. 2015 May 01; 15(5):1106-17.SJ

Abstract

BACKGROUND CONTEXT

The relationships between obesity and low back pain (LBP) and lumbar disc degeneration (LDD) remain unclear. It is possible that familial factors, including genetics and early environment, affect these relationships.

PURPOSE

To investigate the relationship between obesity-related measures (eg, weight, body mass index [BMI]) and LBP and LDD using twin studies, where the effect of genetics and early environment can be controlled.

STUDY DESIGN

A systematic review with meta-analysis.

METHODS

MEDLINE, CINAHL, Scopus, Web of Science, and EMBASE databases were searched from the earliest records to August 2014. All cross-sectional and longitudinal observational twin studies identified by the search strategy were considered for inclusion. Two investigators independently assessed the eligibility, conducted the quality assessment, and extracted the data. Metaanalyses (fixed or random effects, as appropriate) were used to pool studies' estimates of association.

RESULTS

In total, 11 articles met the inclusion criteria. Five studies were included in the LBP analysis and seven in the LDD analysis. For the LBP analysis, pooling of the five studies showed that the risk of having LBP for individuals with the highest levels of BMI or weight was almost twice that of people with a lower BMI (odds ratio [OR] 1.8; 95% confidence interval [CI] 1.6-2.0; I(2)=0%). A dose-response relationship was also identified. When genetics and the effects of a shared early environment were adjusted for using a within-pair twin case-control analysis, pooling of three studies showed a reduced but statistically positive association between obesity and prevalence of LBP (OR 1.5; 95% CI 1.1-2.1; I(2)=0%). However, the association was further diminished and not significant (OR 1.4; 95% CI 0.8-2.3; I(2)=0%) when pooling included two studies on monozygotic twin pairs only. Seven studies met the inclusion criteria for LDD. When familial factors were not controlled for, body weight was positively associated with LDD in all five cross-sectional studies. Only two cross-sectional studies investigated the relationship between obesity-related measures and LDD accounting for familial factors, and the results were conflicting. One longitudinal study in LBP and three longitudinal studies in LDD found no increase in risk in obese individuals, whether or not familial factors were controlled for.

CONCLUSIONS

Findings from this review suggest that genetics and early environment are possible mechanisms underlying the relationship between obesity and LBP; however, a direct causal link between these conditions appears to be weak. Further longitudinal studies using the twin design are needed to better understand the complex mechanisms underlying the associations between obesity, LBP, and LDD.

Authors+Show Affiliations

Discipline of Physiotherapy, Faculty of Health Sciences, The University of Sydney, PO Box 170, 75 East Street Lidcombe, Sydney, NSW, Australia 2141. Electronic address: adar3900@sydney.edu.au.The George Institute for Global Health and Institute of Bone and Joint Research, Kolling Institute, Sydney Medical School, The University of Sydney, Level 13, 321 Kent Street, Sydney, NSW, Australia 2141.Discipline of Physiotherapy, Faculty of Health Sciences, The University of Sydney, PO Box 170, 75 East Street Lidcombe, Sydney, NSW, Australia 2141.Biomechanics and Motor Control Research Group, Science and Technology Faculty-Universidade Estadual Paulista, Presidente Prudente, Sao Paulo, Brazil 19060-900.Murcia Twin Registry, Department of Human Anatomy and Psychobiology, University of Murcia, Spain 30100; IMIB-Arrixaca, Department of Human Anatomy and Psychobiology, Murcia, Spain 30100.Discipline of Physiotherapy, Faculty of Health Sciences, The University of Sydney, PO Box 170, 75 East Street Lidcombe, Sydney, NSW, Australia 2141.

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

25661432

Citation

Dario, Amabile B., et al. "The Relationship Between Obesity, Low Back Pain, and Lumbar Disc Degeneration when Genetics and the Environment Are Considered: a Systematic Review of Twin Studies." The Spine Journal : Official Journal of the North American Spine Society, vol. 15, no. 5, 2015, pp. 1106-17.
Dario AB, Ferreira ML, Refshauge KM, et al. The relationship between obesity, low back pain, and lumbar disc degeneration when genetics and the environment are considered: a systematic review of twin studies. Spine J. 2015;15(5):1106-17.
Dario, A. B., Ferreira, M. L., Refshauge, K. M., Lima, T. S., Ordoñana, J. R., & Ferreira, P. H. (2015). The relationship between obesity, low back pain, and lumbar disc degeneration when genetics and the environment are considered: a systematic review of twin studies. The Spine Journal : Official Journal of the North American Spine Society, 15(5), 1106-17. https://doi.org/10.1016/j.spinee.2015.02.001
Dario AB, et al. The Relationship Between Obesity, Low Back Pain, and Lumbar Disc Degeneration when Genetics and the Environment Are Considered: a Systematic Review of Twin Studies. Spine J. 2015 May 1;15(5):1106-17. PubMed PMID: 25661432.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relationship between obesity, low back pain, and lumbar disc degeneration when genetics and the environment are considered: a systematic review of twin studies. AU - Dario,Amabile B, AU - Ferreira,Manuela L, AU - Refshauge,Kathryn M, AU - Lima,Thais S, AU - Ordoñana,Juan R, AU - Ferreira,Paulo H, Y1 - 2015/02/07/ PY - 2014/09/15/received PY - 2015/01/13/revised PY - 2015/02/01/accepted PY - 2015/2/10/entrez PY - 2015/2/11/pubmed PY - 2015/12/15/medline KW - Body mass index KW - Body weight KW - Genetics KW - Low back pain KW - Lumbar disc degeneration KW - Obesity KW - Twins SP - 1106 EP - 17 JF - The spine journal : official journal of the North American Spine Society JO - Spine J VL - 15 IS - 5 N2 - BACKGROUND CONTEXT: The relationships between obesity and low back pain (LBP) and lumbar disc degeneration (LDD) remain unclear. It is possible that familial factors, including genetics and early environment, affect these relationships. PURPOSE: To investigate the relationship between obesity-related measures (eg, weight, body mass index [BMI]) and LBP and LDD using twin studies, where the effect of genetics and early environment can be controlled. STUDY DESIGN: A systematic review with meta-analysis. METHODS: MEDLINE, CINAHL, Scopus, Web of Science, and EMBASE databases were searched from the earliest records to August 2014. All cross-sectional and longitudinal observational twin studies identified by the search strategy were considered for inclusion. Two investigators independently assessed the eligibility, conducted the quality assessment, and extracted the data. Metaanalyses (fixed or random effects, as appropriate) were used to pool studies' estimates of association. RESULTS: In total, 11 articles met the inclusion criteria. Five studies were included in the LBP analysis and seven in the LDD analysis. For the LBP analysis, pooling of the five studies showed that the risk of having LBP for individuals with the highest levels of BMI or weight was almost twice that of people with a lower BMI (odds ratio [OR] 1.8; 95% confidence interval [CI] 1.6-2.0; I(2)=0%). A dose-response relationship was also identified. When genetics and the effects of a shared early environment were adjusted for using a within-pair twin case-control analysis, pooling of three studies showed a reduced but statistically positive association between obesity and prevalence of LBP (OR 1.5; 95% CI 1.1-2.1; I(2)=0%). However, the association was further diminished and not significant (OR 1.4; 95% CI 0.8-2.3; I(2)=0%) when pooling included two studies on monozygotic twin pairs only. Seven studies met the inclusion criteria for LDD. When familial factors were not controlled for, body weight was positively associated with LDD in all five cross-sectional studies. Only two cross-sectional studies investigated the relationship between obesity-related measures and LDD accounting for familial factors, and the results were conflicting. One longitudinal study in LBP and three longitudinal studies in LDD found no increase in risk in obese individuals, whether or not familial factors were controlled for. CONCLUSIONS: Findings from this review suggest that genetics and early environment are possible mechanisms underlying the relationship between obesity and LBP; however, a direct causal link between these conditions appears to be weak. Further longitudinal studies using the twin design are needed to better understand the complex mechanisms underlying the associations between obesity, LBP, and LDD. SN - 1878-1632 UR - https://www.unboundmedicine.com/medline/citation/25661432/The_relationship_between_obesity_low_back_pain_and_lumbar_disc_degeneration_when_genetics_and_the_environment_are_considered:_a_systematic_review_of_twin_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1529-9430(15)00099-6 DB - PRIME DP - Unbound Medicine ER -