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Memantine prevents "bipolar-like" behavior induced by chronic treatment with imipramine in rats.
Eur J Pharmacol. 2015 Apr 05; 752:49-54.EJ

Abstract

A great deal of evidence suggests that virtually all antidepressant treatments induce a dopaminergic behavioral supersensitivity. We have suggested that this effect may play a key role not only in the antidepressant effect of these treatments, but also in their ability to induce a switch from depression to mania. In 2003-4 we found that the sensitization of dopamine receptors induced by imipramine is followed, after imipramine withdrawal, by a desensitization of these receptors associated with a depressive-like behavior assessed in the forced swimming test. The dopamine receptor sensitization can be prevented by MK-801, an NMDA receptor antagonist, but not by currently used mood stabilizers (lithium, carbamazepine, valproate). These observations led us to suggest - and later confirm - with preliminary clinical observations that memantine may have an acute antimanic and a long-lasting mood-stabilizing effect in treatment-resistant bipolar disorder patients. Here we present data showing that memantine prevents not only the dopamine receptor sensitization induced by imipramine, as observed with MK-801, but also the ensuing desensitization and the associated depressive-like behaviorq observed after antidepressant withdrawal.

Authors+Show Affiliations

Dipartimento di Scienze Biomediche, Università di Sassari, Italy.Dipartimento di Scienze Biomediche, Università di Sassari, Italy.Dipartimento di Scienze Biomediche, Università di Sassari, Italy.Dipartimento di Scienze Biomediche, Università di Sassari, Italy. Electronic address: dsfserra@uniss.it.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25661848

Citation

Demontis, Francesca, et al. "Memantine Prevents "bipolar-like" Behavior Induced By Chronic Treatment With Imipramine in Rats." European Journal of Pharmacology, vol. 752, 2015, pp. 49-54.
Demontis F, Falconi M, Canu D, et al. Memantine prevents "bipolar-like" behavior induced by chronic treatment with imipramine in rats. Eur J Pharmacol. 2015;752:49-54.
Demontis, F., Falconi, M., Canu, D., & Serra, G. (2015). Memantine prevents "bipolar-like" behavior induced by chronic treatment with imipramine in rats. European Journal of Pharmacology, 752, 49-54. https://doi.org/10.1016/j.ejphar.2015.01.041
Demontis F, et al. Memantine Prevents "bipolar-like" Behavior Induced By Chronic Treatment With Imipramine in Rats. Eur J Pharmacol. 2015 Apr 5;752:49-54. PubMed PMID: 25661848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Memantine prevents "bipolar-like" behavior induced by chronic treatment with imipramine in rats. AU - Demontis,Francesca, AU - Falconi,Marcella, AU - Canu,Desirèe, AU - Serra,Gino, Y1 - 2015/02/04/ PY - 2014/07/30/received PY - 2015/01/11/revised PY - 2015/01/22/accepted PY - 2015/2/10/entrez PY - 2015/2/11/pubmed PY - 2015/12/19/medline KW - Antimanic KW - Bipolar disorder KW - Dopamine receptors KW - Memantine KW - Mood stabilizer SP - 49 EP - 54 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 752 N2 - A great deal of evidence suggests that virtually all antidepressant treatments induce a dopaminergic behavioral supersensitivity. We have suggested that this effect may play a key role not only in the antidepressant effect of these treatments, but also in their ability to induce a switch from depression to mania. In 2003-4 we found that the sensitization of dopamine receptors induced by imipramine is followed, after imipramine withdrawal, by a desensitization of these receptors associated with a depressive-like behavior assessed in the forced swimming test. The dopamine receptor sensitization can be prevented by MK-801, an NMDA receptor antagonist, but not by currently used mood stabilizers (lithium, carbamazepine, valproate). These observations led us to suggest - and later confirm - with preliminary clinical observations that memantine may have an acute antimanic and a long-lasting mood-stabilizing effect in treatment-resistant bipolar disorder patients. Here we present data showing that memantine prevents not only the dopamine receptor sensitization induced by imipramine, as observed with MK-801, but also the ensuing desensitization and the associated depressive-like behaviorq observed after antidepressant withdrawal. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/25661848/Memantine_prevents_"bipolar_like"_behavior_induced_by_chronic_treatment_with_imipramine_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(15)00074-6 DB - PRIME DP - Unbound Medicine ER -