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Consumption of fruit and vegetable and risk of coronary heart disease: a meta-analysis of prospective cohort studies.
Int J Cardiol 2015; 183:129-37IJ

Abstract

BACKGROUND

Observational studies suggest that an association between fruit and vegetable consumption and coronary heart disease (CHD). However, the results are inconsistent. We conducted a meta-analysis to evaluate the relationship of fruit and vegetable consumption with CHD risk and quality the dose-response relationship between them.

METHODS

Relevant prospective studies were identified by a search of PubMed, Embase and Web of Science databases to July 2014. A random-effects model was used to calculate the pooled relative risk (RR) and 95% confidence intervals (CI).

RESULTS

Twenty-three studies involving 937,665 participants and 18,047 patients with CHD were included. Compared with the lowest consumption levels of total fruit and vegetable, fruit and vegetable, the RR of CHD was 0.84 (95% CI, 0.79-0.90), 0.86 (95% CI, 0.82-0.91), 0.87 (95% CI, 0.81-0.93), respectively. The dose-response analysis indicated that, the RR of CHD was 0.88 (95% CI: 0.85-0.91) per 477 g/day of total fruit and vegetable consumption, 0.84 (95% CI: 0.75-0.93) per 300 g/day of fruit intake and 0.82 (95% CI: 0.73-0.92) per 400 g/day of vegetable consumption. A nonlinear association of CHD risk with fruit or vegetable consumption separately was found (P for nonlinearity <0.001). In the subgroup analysis of location, a significant inverse association was observed in Western populations, but not in Asian populations.

CONCLUSIONS

This meta-analysis indicates that total fruit and vegetable, fruit and vegetable consumption, are significantly associated with a lower risk of CHD. The significant inverse association was found in Western populations, but not in Asian populations, which warrants further research.

Authors+Show Affiliations

Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Management, School of Economics and Management, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Social Medicine and Health Management, School of Public Health, Shenyang Medical College, Shenyang, Liaoning, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address: zuxunlu@yahoo.com.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25662075

Citation

Gan, Yong, et al. "Consumption of Fruit and Vegetable and Risk of Coronary Heart Disease: a Meta-analysis of Prospective Cohort Studies." International Journal of Cardiology, vol. 183, 2015, pp. 129-37.
Gan Y, Tong X, Li L, et al. Consumption of fruit and vegetable and risk of coronary heart disease: a meta-analysis of prospective cohort studies. Int J Cardiol. 2015;183:129-37.
Gan, Y., Tong, X., Li, L., Cao, S., Yin, X., Gao, C., ... Lu, Z. (2015). Consumption of fruit and vegetable and risk of coronary heart disease: a meta-analysis of prospective cohort studies. International Journal of Cardiology, 183, pp. 129-37. doi:10.1016/j.ijcard.2015.01.077.
Gan Y, et al. Consumption of Fruit and Vegetable and Risk of Coronary Heart Disease: a Meta-analysis of Prospective Cohort Studies. Int J Cardiol. 2015 Mar 15;183:129-37. PubMed PMID: 25662075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of fruit and vegetable and risk of coronary heart disease: a meta-analysis of prospective cohort studies. AU - Gan,Yong, AU - Tong,Xinyue, AU - Li,Liqing, AU - Cao,Shiyi, AU - Yin,Xiaoxv, AU - Gao,Chao, AU - Herath,Chulani, AU - Li,Wenzhen, AU - Jin,Zhe, AU - Chen,Yawen, AU - Lu,Zuxun, Y1 - 2015/01/27/ PY - 2014/12/10/received PY - 2015/01/26/accepted PY - 2015/2/10/entrez PY - 2015/2/11/pubmed PY - 2016/3/2/medline KW - Coronary heart disease KW - Fruit KW - Meta-analysis KW - Vegetable SP - 129 EP - 37 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 183 N2 - BACKGROUND: Observational studies suggest that an association between fruit and vegetable consumption and coronary heart disease (CHD). However, the results are inconsistent. We conducted a meta-analysis to evaluate the relationship of fruit and vegetable consumption with CHD risk and quality the dose-response relationship between them. METHODS: Relevant prospective studies were identified by a search of PubMed, Embase and Web of Science databases to July 2014. A random-effects model was used to calculate the pooled relative risk (RR) and 95% confidence intervals (CI). RESULTS: Twenty-three studies involving 937,665 participants and 18,047 patients with CHD were included. Compared with the lowest consumption levels of total fruit and vegetable, fruit and vegetable, the RR of CHD was 0.84 (95% CI, 0.79-0.90), 0.86 (95% CI, 0.82-0.91), 0.87 (95% CI, 0.81-0.93), respectively. The dose-response analysis indicated that, the RR of CHD was 0.88 (95% CI: 0.85-0.91) per 477 g/day of total fruit and vegetable consumption, 0.84 (95% CI: 0.75-0.93) per 300 g/day of fruit intake and 0.82 (95% CI: 0.73-0.92) per 400 g/day of vegetable consumption. A nonlinear association of CHD risk with fruit or vegetable consumption separately was found (P for nonlinearity <0.001). In the subgroup analysis of location, a significant inverse association was observed in Western populations, but not in Asian populations. CONCLUSIONS: This meta-analysis indicates that total fruit and vegetable, fruit and vegetable consumption, are significantly associated with a lower risk of CHD. The significant inverse association was found in Western populations, but not in Asian populations, which warrants further research. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/25662075/Consumption_of_fruit_and_vegetable_and_risk_of_coronary_heart_disease:_a_meta_analysis_of_prospective_cohort_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(15)00104-7 DB - PRIME DP - Unbound Medicine ER -