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Association between coeliac disease and psoriasis: Italian primary care multicentre study.
Dermatology 2015; 230(2):156-60D

Abstract

BACKGROUND

Studies assessing the association between coeliac disease (CD) and psoriasis show conflicting results.

OBJECTIVE

To assess in the primary care setting the prevalence of CD in patients with psoriasis and the response to a gluten-free diet (GFD) in subjects with psoriasis and CD.

METHODS

We enrolled 218 patients with psoriasis and 264 controls. Coeliac screening was carried out in all subjects (Eurospital, Trieste, Italy). In subjects with a positive serology, the diagnosis of CD was confirmed histologically.

RESULTS

Nine (4.1%) psoriatic patients had positive anti-tissue transglutaminase antibodies compared to only 1 among controls (0.4%, p < 0.05; OR 2.03, 95% CI 1.42-90.11). The diagnosis of CD was confirmed histologically in all 10 subjects. At 6 months GFD was associated with a great improvement of skin lesions in 7 out of 8 patients with psoriasis.

CONCLUSION

Our multicentre primary care study showed an high prevalence of CD in psoriasis and an improvement of skin lesions in CD under GFD.

Authors+Show Affiliations

GIGA-CP (Italian Group for Primary Care Gastroenterology), Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

25662711

Citation

De Bastiani, Rudi, et al. "Association Between Coeliac Disease and Psoriasis: Italian Primary Care Multicentre Study." Dermatology (Basel, Switzerland), vol. 230, no. 2, 2015, pp. 156-60.
De Bastiani R, Gabrielli M, Lora L, et al. Association between coeliac disease and psoriasis: Italian primary care multicentre study. Dermatology (Basel). 2015;230(2):156-60.
De Bastiani, R., Gabrielli, M., Lora, L., Napoli, L., Tosetti, C., Pirrotta, E., ... Gasbarrini, A. (2015). Association between coeliac disease and psoriasis: Italian primary care multicentre study. Dermatology (Basel, Switzerland), 230(2), pp. 156-60. doi:10.1159/000369615.
De Bastiani R, et al. Association Between Coeliac Disease and Psoriasis: Italian Primary Care Multicentre Study. Dermatology (Basel). 2015;230(2):156-60. PubMed PMID: 25662711.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between coeliac disease and psoriasis: Italian primary care multicentre study. AU - De Bastiani,Rudi, AU - Gabrielli,Maurizio, AU - Lora,Liliana, AU - Napoli,Luigi, AU - Tosetti,Cesare, AU - Pirrotta,Enzo, AU - Ubaldi,Enzo, AU - Bertolusso,Luciano, AU - Zamparella,Maria, AU - De Polo,Manuela, AU - Nebiacolombo,Cristina, AU - Bortot,Mario, AU - Mancuso,Maurizio, AU - Bacchin,Paolo, AU - Marsala,Valerio, AU - Pinna,Roberto, AU - Tursi,Antonio, AU - Benedetto,Edoardo, AU - Cuffari,Alfredo, AU - Pati,Antonino, AU - Di Caro,Simona, AU - Perenzin,Gastone, AU - Sala,Raffaella, AU - Calzavara Pinton,Giacomo, AU - Gasbarrini,Antonio, Y1 - 2015/02/03/ PY - 2014/01/29/received PY - 2014/10/17/accepted PY - 2015/2/10/entrez PY - 2015/2/11/pubmed PY - 2015/12/19/medline SP - 156 EP - 60 JF - Dermatology (Basel, Switzerland) JO - Dermatology (Basel) VL - 230 IS - 2 N2 - BACKGROUND: Studies assessing the association between coeliac disease (CD) and psoriasis show conflicting results. OBJECTIVE: To assess in the primary care setting the prevalence of CD in patients with psoriasis and the response to a gluten-free diet (GFD) in subjects with psoriasis and CD. METHODS: We enrolled 218 patients with psoriasis and 264 controls. Coeliac screening was carried out in all subjects (Eurospital, Trieste, Italy). In subjects with a positive serology, the diagnosis of CD was confirmed histologically. RESULTS: Nine (4.1%) psoriatic patients had positive anti-tissue transglutaminase antibodies compared to only 1 among controls (0.4%, p < 0.05; OR 2.03, 95% CI 1.42-90.11). The diagnosis of CD was confirmed histologically in all 10 subjects. At 6 months GFD was associated with a great improvement of skin lesions in 7 out of 8 patients with psoriasis. CONCLUSION: Our multicentre primary care study showed an high prevalence of CD in psoriasis and an improvement of skin lesions in CD under GFD. SN - 1421-9832 UR - https://www.unboundmedicine.com/medline/citation/25662711/Association_between_coeliac_disease_and_psoriasis:_Italian_primary_care_multicentre_study_ L2 - https://www.karger.com?DOI=10.1159/000369615 DB - PRIME DP - Unbound Medicine ER -