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T-cell acute lymphoid leukemia resembling Burkitt leukemia cell morphology: A case report.
Oncol Lett. 2015 Mar; 9(3):1236-1238.OL

Abstract

Biphenotypic acute leukemia (BAL) is an uncommon type of cancer, which accounts for <5% of all adult ALs. Based upon a previously described scoring system, the European Group for the Immunological Classification of Leukemias (EGIL) proposed a set of diagnostic criteria for BAL. This scoring system is based upon the number and degree of specificity of several markers for myeloid or T/B-lymphoid blasts. The present study describes a case of T-cell acute lymphoblastic leukemia (T-ALL) with Burkitt-like cytology, which according to the French-American-British classification, corresponded to a diagnosis of Burkitt type L3 ALL. Flow cytometry analysis demonstrated that the blasts were positive for T-lymphoid markers, cytoplasmic cluster of differentiation (CD)3, CD7 and CD56, and myeloid markers, CD13, CD33 and CD15. At first, a diagnosis of BAL was suggested by the EGIL score, however, according to the 2008 World Health Organization criteria, a case of T-ALL with aberrant myeloid markers was established. The study also reviewed the literature and discussed the limitations of the EGIL scoring system in clinical decision making, to aid in the selection of an appropriate therapeutic regimen.

Authors+Show Affiliations

Department of Hematology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.Department of Hematology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.Department of Hematology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.Department of Hematology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.Department of Hematology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25663889

Citation

Yue, Qingfang, et al. "T-cell Acute Lymphoid Leukemia Resembling Burkitt Leukemia Cell Morphology: a Case Report." Oncology Letters, vol. 9, no. 3, 2015, pp. 1236-1238.
Yue Q, Liu X, Chen L, et al. T-cell acute lymphoid leukemia resembling Burkitt leukemia cell morphology: A case report. Oncol Lett. 2015;9(3):1236-1238.
Yue, Q., Liu, X., Chen, L., Liu, Z., & Chen, W. (2015). T-cell acute lymphoid leukemia resembling Burkitt leukemia cell morphology: A case report. Oncology Letters, 9(3), 1236-1238.
Yue Q, et al. T-cell Acute Lymphoid Leukemia Resembling Burkitt Leukemia Cell Morphology: a Case Report. Oncol Lett. 2015;9(3):1236-1238. PubMed PMID: 25663889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - T-cell acute lymphoid leukemia resembling Burkitt leukemia cell morphology: A case report. AU - Yue,Qingfang, AU - Liu,Xinyue, AU - Chen,Lei, AU - Liu,Zhongping, AU - Chen,Wanxin, Y1 - 2014/12/23/ PY - 2014/05/12/received PY - 2014/11/25/accepted PY - 2015/2/10/entrez PY - 2015/2/11/pubmed PY - 2015/2/11/medline KW - Burkitt leukemia KW - acute lymphoblastic leukemia KW - biphenotypic acute leukemia SP - 1236 EP - 1238 JF - Oncology letters JO - Oncol Lett VL - 9 IS - 3 N2 - Biphenotypic acute leukemia (BAL) is an uncommon type of cancer, which accounts for <5% of all adult ALs. Based upon a previously described scoring system, the European Group for the Immunological Classification of Leukemias (EGIL) proposed a set of diagnostic criteria for BAL. This scoring system is based upon the number and degree of specificity of several markers for myeloid or T/B-lymphoid blasts. The present study describes a case of T-cell acute lymphoblastic leukemia (T-ALL) with Burkitt-like cytology, which according to the French-American-British classification, corresponded to a diagnosis of Burkitt type L3 ALL. Flow cytometry analysis demonstrated that the blasts were positive for T-lymphoid markers, cytoplasmic cluster of differentiation (CD)3, CD7 and CD56, and myeloid markers, CD13, CD33 and CD15. At first, a diagnosis of BAL was suggested by the EGIL score, however, according to the 2008 World Health Organization criteria, a case of T-ALL with aberrant myeloid markers was established. The study also reviewed the literature and discussed the limitations of the EGIL scoring system in clinical decision making, to aid in the selection of an appropriate therapeutic regimen. SN - 1792-1074 UR - https://www.unboundmedicine.com/medline/citation/25663889/T_cell_acute_lymphoid_leukemia_resembling_Burkitt_leukemia_cell_morphology:_A_case_report_ L2 - https://www.ingentaconnect.com/openurl?genre=article&amp;issn=1792-1074&amp;volume=9&amp;issue=3&amp;spage=1236&amp;aulast=Yue DB - PRIME DP - Unbound Medicine ER -
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