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Endogenous hormones, inflammation, and body size in premenopausal Mexican women: results from the Mexican Teachers' Cohort (MTC, ESMaestras).

Abstract

PURPOSE

Obesity is a major risk factor for several cancers, including female cancers. Endogenous hormones and inflammatory factors may mediate the association between anthropometric measures and cancer risk, although these associations have been studied mainly in Caucasians. The aim of the current study was to explore the association of circulating hormones, adipokines, and inflammatory factors with obesity and overweight in premenopausal Mexican women.

METHODS

We conducted a cross-sectional analysis of 504 premenopausal women from the large Mexican Teachers' Cohort (MTC, ESMaestras) study to determine the association of insulin-like growth factor I (IGF-I), its major circulating binding protein (IGFBP-3), leptin, adiponectin, C-peptide, and C-reactive protein with comprehensive measures of body size. Biomarkers were measured by immunoassays. Multivariate regression analyses were performed to compare geometric mean biomarker concentrations with measured markers of body size and adiposity.

RESULTS

Mean IGF-I and IGFBP-3 concentrations significantly increased with increasing height and leg length. Concentrations of IGF-I, adiponectin, and the IGF-I/IGFBP-3 ratio strongly decreased with increasing BMI, weight, waist and hip circumferences, waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR), while CRP, leptin, C-peptide concentrations, and the leptin/adiponectin ratio strongly increased. Adiponectin and the leptin/adiponectin ratio remained significantly related to measures of central adiposity (waist circumference, WHpR, and WHtR) after adjustment by body mass index.

CONCLUSIONS

The results of our study suggest a strong relation between biomarkers and body size in this study population and suggest that different fat depots may have different metabolic properties.

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  • Authors+Show Affiliations

    ,

    International Agency for Research on Cancer (IARC), Lyon, France.

    , , , , , , ,

    Source

    Cancer causes & control : CCC 26:3 2015 Mar pg 475-86

    MeSH

    Adiposity
    Adult
    Biomarkers
    Body Mass Index
    Body Size
    Body Weight
    C-Peptide
    C-Reactive Protein
    Cohort Studies
    Cross-Sectional Studies
    Female
    Humans
    Immunoassay
    Inflammation
    Insulin-Like Growth Factor Binding Protein 3
    Insulin-Like Growth Factor I
    Leptin
    Mexico
    Middle Aged
    Multivariate Analysis
    Obesity
    Overweight
    Premenopause
    Waist Circumference
    Waist-Hip Ratio

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    25665532

    Citation

    Rinaldi, Sabina, et al. "Endogenous Hormones, Inflammation, and Body Size in Premenopausal Mexican Women: Results From the Mexican Teachers' Cohort (MTC, ESMaestras)." Cancer Causes & Control : CCC, vol. 26, no. 3, 2015, pp. 475-86.
    Rinaldi S, Biessy C, de la Luz Hernandez M, et al. Endogenous hormones, inflammation, and body size in premenopausal Mexican women: results from the Mexican Teachers' Cohort (MTC, ESMaestras). Cancer Causes Control. 2015;26(3):475-86.
    Rinaldi, S., Biessy, C., de la Luz Hernandez, M., Lajous, M., Ortiz-Panozo, E., Yunes, E., ... Romieu, I. (2015). Endogenous hormones, inflammation, and body size in premenopausal Mexican women: results from the Mexican Teachers' Cohort (MTC, ESMaestras). Cancer Causes & Control : CCC, 26(3), pp. 475-86. doi:10.1007/s10552-015-0527-2.
    Rinaldi S, et al. Endogenous Hormones, Inflammation, and Body Size in Premenopausal Mexican Women: Results From the Mexican Teachers' Cohort (MTC, ESMaestras). Cancer Causes Control. 2015;26(3):475-86. PubMed PMID: 25665532.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Endogenous hormones, inflammation, and body size in premenopausal Mexican women: results from the Mexican Teachers' Cohort (MTC, ESMaestras). AU - Rinaldi,Sabina, AU - Biessy,Carine, AU - de la Luz Hernandez,Maria, AU - Lajous,Martin, AU - Ortiz-Panozo,Eduardo, AU - Yunes,Elsa, AU - Lopez-Ridaura,Ruy, AU - Torres-Mejia,Gabriela, AU - Romieu,Isabelle, Y1 - 2015/02/11/ PY - 2014/09/29/received PY - 2015/01/19/accepted PY - 2015/2/11/entrez PY - 2015/2/11/pubmed PY - 2016/3/30/medline SP - 475 EP - 86 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 26 IS - 3 N2 - PURPOSE: Obesity is a major risk factor for several cancers, including female cancers. Endogenous hormones and inflammatory factors may mediate the association between anthropometric measures and cancer risk, although these associations have been studied mainly in Caucasians. The aim of the current study was to explore the association of circulating hormones, adipokines, and inflammatory factors with obesity and overweight in premenopausal Mexican women. METHODS: We conducted a cross-sectional analysis of 504 premenopausal women from the large Mexican Teachers' Cohort (MTC, ESMaestras) study to determine the association of insulin-like growth factor I (IGF-I), its major circulating binding protein (IGFBP-3), leptin, adiponectin, C-peptide, and C-reactive protein with comprehensive measures of body size. Biomarkers were measured by immunoassays. Multivariate regression analyses were performed to compare geometric mean biomarker concentrations with measured markers of body size and adiposity. RESULTS: Mean IGF-I and IGFBP-3 concentrations significantly increased with increasing height and leg length. Concentrations of IGF-I, adiponectin, and the IGF-I/IGFBP-3 ratio strongly decreased with increasing BMI, weight, waist and hip circumferences, waist-to-hip ratio (WHpR), and waist-to-height ratio (WHtR), while CRP, leptin, C-peptide concentrations, and the leptin/adiponectin ratio strongly increased. Adiponectin and the leptin/adiponectin ratio remained significantly related to measures of central adiposity (waist circumference, WHpR, and WHtR) after adjustment by body mass index. CONCLUSIONS: The results of our study suggest a strong relation between biomarkers and body size in this study population and suggest that different fat depots may have different metabolic properties. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/25665532/Endogenous_hormones_inflammation_and_body_size_in_premenopausal_Mexican_women:_results_from_the_Mexican_Teachers'_Cohort__MTC_ESMaestras__ L2 - https://doi.org/10.1007/s10552-015-0527-2 DB - PRIME DP - Unbound Medicine ER -