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Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA).
Br J Cancer. 2015 Mar 31; 112(7):1291-300.BJ

Abstract

BACKGROUND

Flavonoids, polyphenolic compounds concentrated in fruits and vegetables, have experimentally demonstrated chemopreventive effects against oesophageal and gastric cancer. Few epidemiologic studies have examined flavonoid intake and incidence of these cancers, and none have considered survival.

METHODS

In this USA multicentre population-based study, case participants (diagnosed during 1993-1995 with oesophageal adenocarcinoma (OEA, n=274), gastric cardia adenocarcinoma (GCA, n=248), oesophageal squamous cell carcinoma (OES, n=191), and other gastric adenocarcinoma (OGA, n=341)) and frequency-matched controls (n=662) were interviewed. Food frequency questionnaire responses were linked with USDA Flavonoid Databases and available literature for six flavonoid classes and lignans. Case participants were followed until 2000 for vital status. Multivariable-adjusted odds ratios (ORs) and hazard ratios (HRs) (95% confidence intervals (CIs)) were estimated, comparing highest with lowest intake quartiles, using polytomous logistic and proportional hazards regressions, respectively.

RESULTS

Little or no consistent association was found for total flavonoid intake (main population sources: black tea, orange/grapefruit juice, and wine) and incidence or survival for any tumour type. Intake of anthocyanidins, common in wine and fruit juice, was associated with a 57% reduction in the risk of incident OEA (OR=0.43, 95% CI=0.29-0.66) and OES (OR=0.43, 95% CI=0.26-0.70). The ORs for isoflavones, for which coffee was the main source, were increased for all tumours, except OES. Anthocyanidins were associated with decreased risk of mortality for GCA (HR=0.63, 95% CI=0.42-0.95) and modestly for OEA (HR=0.87, 95% CI=0.60-1.26), but CIs were wide.

CONCLUSIONS

Our findings, if confirmed, suggest that increased dietary anthocyanidin intake may reduce incidence and improve survival for these cancers.

Authors+Show Affiliations

Department of Epidemiology, CB 7435, University of North Carolina, Chapel Hill, NC 27599-7435, USA.Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, USA.Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA.Division of Cancer Prevention and Control, Centers for Disease Control, Atlanta, GA, USA.Salmon Bay Consulting, Inc., Seattle, WA, USA.Department of Epidemiology, CB 7435, University of North Carolina, Chapel Hill, NC 27599-7435, USA.Department of Epidemiology and Biostatistics, Indiana University, Bloomington, IN, USA.Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.Department of Chronic Disease Epidemiology, Yale School of Public Health and Yale Cancer Center, New Haven, CT, USA.Department of Chronic Disease Epidemiology, Yale School of Public Health and Yale Cancer Center, New Haven, CT, USA.Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.Department of Epidemiology, CB 7435, University of North Carolina, Chapel Hill, NC 27599-7435, USA.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25668011

Citation

Petrick, J L., et al. "Dietary Intake of Flavonoids and Oesophageal and Gastric Cancer: Incidence and Survival in the United States of America (USA)." British Journal of Cancer, vol. 112, no. 7, 2015, pp. 1291-300.
Petrick JL, Steck SE, Bradshaw PT, et al. Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA). Br J Cancer. 2015;112(7):1291-300.
Petrick, J. L., Steck, S. E., Bradshaw, P. T., Trivers, K. F., Abrahamson, P. E., Engel, L. S., He, K., Chow, W. H., Mayne, S. T., Risch, H. A., Vaughan, T. L., & Gammon, M. D. (2015). Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA). British Journal of Cancer, 112(7), 1291-300. https://doi.org/10.1038/bjc.2015.25
Petrick JL, et al. Dietary Intake of Flavonoids and Oesophageal and Gastric Cancer: Incidence and Survival in the United States of America (USA). Br J Cancer. 2015 Mar 31;112(7):1291-300. PubMed PMID: 25668011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of flavonoids and oesophageal and gastric cancer: incidence and survival in the United States of America (USA). AU - Petrick,J L, AU - Steck,S E, AU - Bradshaw,P T, AU - Trivers,K F, AU - Abrahamson,P E, AU - Engel,L S, AU - He,K, AU - Chow,W-H, AU - Mayne,S T, AU - Risch,H A, AU - Vaughan,T L, AU - Gammon,M D, Y1 - 2015/03/31/ PY - 2014/08/07/received PY - 2014/12/16/revised PY - 2015/01/08/accepted PY - 2015/2/11/entrez PY - 2015/2/11/pubmed PY - 2015/6/20/medline SP - 1291 EP - 300 JF - British journal of cancer JO - Br. J. Cancer VL - 112 IS - 7 N2 - BACKGROUND: Flavonoids, polyphenolic compounds concentrated in fruits and vegetables, have experimentally demonstrated chemopreventive effects against oesophageal and gastric cancer. Few epidemiologic studies have examined flavonoid intake and incidence of these cancers, and none have considered survival. METHODS: In this USA multicentre population-based study, case participants (diagnosed during 1993-1995 with oesophageal adenocarcinoma (OEA, n=274), gastric cardia adenocarcinoma (GCA, n=248), oesophageal squamous cell carcinoma (OES, n=191), and other gastric adenocarcinoma (OGA, n=341)) and frequency-matched controls (n=662) were interviewed. Food frequency questionnaire responses were linked with USDA Flavonoid Databases and available literature for six flavonoid classes and lignans. Case participants were followed until 2000 for vital status. Multivariable-adjusted odds ratios (ORs) and hazard ratios (HRs) (95% confidence intervals (CIs)) were estimated, comparing highest with lowest intake quartiles, using polytomous logistic and proportional hazards regressions, respectively. RESULTS: Little or no consistent association was found for total flavonoid intake (main population sources: black tea, orange/grapefruit juice, and wine) and incidence or survival for any tumour type. Intake of anthocyanidins, common in wine and fruit juice, was associated with a 57% reduction in the risk of incident OEA (OR=0.43, 95% CI=0.29-0.66) and OES (OR=0.43, 95% CI=0.26-0.70). The ORs for isoflavones, for which coffee was the main source, were increased for all tumours, except OES. Anthocyanidins were associated with decreased risk of mortality for GCA (HR=0.63, 95% CI=0.42-0.95) and modestly for OEA (HR=0.87, 95% CI=0.60-1.26), but CIs were wide. CONCLUSIONS: Our findings, if confirmed, suggest that increased dietary anthocyanidin intake may reduce incidence and improve survival for these cancers. SN - 1532-1827 UR - https://www.unboundmedicine.com/medline/citation/25668011/Dietary_intake_of_flavonoids_and_oesophageal_and_gastric_cancer:_incidence_and_survival_in_the_United_States_of_America__USA__ L2 - http://dx.doi.org/10.1038/bjc.2015.25 DB - PRIME DP - Unbound Medicine ER -