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Dietary cysteine and other amino acids and stroke incidence in women.
Stroke 2015; 46(4):922-6S

Abstract

BACKGROUND AND PURPOSE

Cysteine could potentially lower the risk of stroke through antihypertensive and antioxidant effects. Our aim was to evaluate the hypothesis that cysteine intake is inversely associated with stroke incidence.

METHODS

We used data from the Swedish Mammography Cohort, a population-based prospective cohort of 34 250 women who were free of cardiovascular disease and cancer and had completed a food-frequency questionnaire about diet and other risk factors for stroke in the autumn of 1997. Stroke cases were identified by linkage of the study population with the Swedish Inpatient Register and the Swedish Cause of Death Register. Relative risks (RR) with 95% confidence intervals, adjusted for potential confounders, were estimated by using Cox proportional hazards regression model.

RESULTS

We ascertained 1751 incident cases of stroke during 10.4 years of follow-up. Dietary cysteine intake (mean, 635 mg/d) was inversely associated with stroke risk. The multivariable RR of total stroke comparing the highest with the lowest quintile of cysteine intake was 0.79 (95% confidence interval, 0.65-0.97; P for trend=0.04). The corresponding RR was 0.82 (95% confidence interval, 0.65-1.03; P for trend=0.12) for cerebral infarction and 0.54 (95% confidence interval, 0.29-1.03; P for trend=0.08) for intracerebral hemorrhage. Dietary intake of other amino acids showed no independent (after adjustment for cysteine intake) association with stroke risk.

CONCLUSIONS

These findings suggest that dietary cysteine intake may be inversely associated with risk of stroke.

CLINICAL TRIAL REGISTRATION

URL: http://www.clinicaltrials.gov. Unique identifier: NCT01127698.

Authors+Show Affiliations

From the Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. susanna.larsson@ki.se.From the Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.From the Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25669310

Citation

Larsson, Susanna C., et al. "Dietary Cysteine and Other Amino Acids and Stroke Incidence in Women." Stroke, vol. 46, no. 4, 2015, pp. 922-6.
Larsson SC, Håkansson N, Wolk A. Dietary cysteine and other amino acids and stroke incidence in women. Stroke. 2015;46(4):922-6.
Larsson, S. C., Håkansson, N., & Wolk, A. (2015). Dietary cysteine and other amino acids and stroke incidence in women. Stroke, 46(4), pp. 922-6. doi:10.1161/STROKEAHA.114.008022.
Larsson SC, Håkansson N, Wolk A. Dietary Cysteine and Other Amino Acids and Stroke Incidence in Women. Stroke. 2015;46(4):922-6. PubMed PMID: 25669310.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary cysteine and other amino acids and stroke incidence in women. AU - Larsson,Susanna C, AU - Håkansson,Niclas, AU - Wolk,Alicja, Y1 - 2015/02/10/ PY - 2015/2/12/entrez PY - 2015/2/12/pubmed PY - 2015/6/13/medline KW - 14-3-3 proteins KW - amino acids KW - blood pressure KW - hypertension KW - prospective studies KW - stroke SP - 922 EP - 6 JF - Stroke JO - Stroke VL - 46 IS - 4 N2 - BACKGROUND AND PURPOSE: Cysteine could potentially lower the risk of stroke through antihypertensive and antioxidant effects. Our aim was to evaluate the hypothesis that cysteine intake is inversely associated with stroke incidence. METHODS: We used data from the Swedish Mammography Cohort, a population-based prospective cohort of 34 250 women who were free of cardiovascular disease and cancer and had completed a food-frequency questionnaire about diet and other risk factors for stroke in the autumn of 1997. Stroke cases were identified by linkage of the study population with the Swedish Inpatient Register and the Swedish Cause of Death Register. Relative risks (RR) with 95% confidence intervals, adjusted for potential confounders, were estimated by using Cox proportional hazards regression model. RESULTS: We ascertained 1751 incident cases of stroke during 10.4 years of follow-up. Dietary cysteine intake (mean, 635 mg/d) was inversely associated with stroke risk. The multivariable RR of total stroke comparing the highest with the lowest quintile of cysteine intake was 0.79 (95% confidence interval, 0.65-0.97; P for trend=0.04). The corresponding RR was 0.82 (95% confidence interval, 0.65-1.03; P for trend=0.12) for cerebral infarction and 0.54 (95% confidence interval, 0.29-1.03; P for trend=0.08) for intracerebral hemorrhage. Dietary intake of other amino acids showed no independent (after adjustment for cysteine intake) association with stroke risk. CONCLUSIONS: These findings suggest that dietary cysteine intake may be inversely associated with risk of stroke. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01127698. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/25669310/Dietary_cysteine_and_other_amino_acids_and_stroke_incidence_in_women_ L2 - http://www.ahajournals.org/doi/full/10.1161/STROKEAHA.114.008022?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -