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A systematic review of extravasation and local tissue injury from administration of vasopressors through peripheral intravenous catheters and central venous catheters.
J Crit Care. 2015 Jun; 30(3):653.e9-17.JC

Abstract

PURPOSE

The aim of this study was to collect and describe all published reports of local tissue injury or extravasation from vasopressor administration via either peripheral intravenous (IV) or central venous catheter.

METHODS

A systematic search of Medline, Embase, and Cochrane databases was performed from inception through January 2014 for reports of adults who received vasopressor intravenously via peripheral IV or central venous catheter for a therapeutic purpose. We included primary studies or case reports of vasopressor administration that resulted in local tissue injury or extravasation of vasopressor solution.

RESULTS

Eighty-five articles with 270 patients met all inclusion criteria. A total of 325 separate local tissue injury and extravasation events were identified, with 318 events resulting from peripheral vasopressor administration and 7 events resulting from central administration. There were 204 local tissue injury events from peripheral administration of vasopressors, with an average duration of infusion of 55.9 hours (±68.1), median time of 24 hours, and range of 0.08 to 528 hours. In most of these events (174/204, 85.3%), the infusion site was located distal to the antecubital or popliteal fossae.

CONCLUSIONS

Published data on tissue injury or extravasation from vasopressor administration via peripheral IVs are derived mainly from case reports. Further study is warranted to clarify the safety of vasopressor administration via peripheral IVs.

Authors+Show Affiliations

Departments of Critical Care Medicine and Emergency Medicine, Dalhousie University, Room 377, Bethune Building, 1276 South Park St, Halifax, Nova Scotia B3H 2Y9, Canada. Electronic address: Oloubani@dal.ca.Departments of Critical Care Medicine and Emergency Medicine, Dalhousie University, Room 377, Bethune Building, 1276 South Park St, Halifax, Nova Scotia B3H 2Y9, Canada; Trauma Nova Scotia, 1276 South Park St, Centennial Building Room 1-026B, Halifax, Nova Scotia B3H 2Y9, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

25669592

Citation

Loubani, Osama M., and Robert S. Green. "A Systematic Review of Extravasation and Local Tissue Injury From Administration of Vasopressors Through Peripheral Intravenous Catheters and Central Venous Catheters." Journal of Critical Care, vol. 30, no. 3, 2015, pp. 653.e9-17.
Loubani OM, Green RS. A systematic review of extravasation and local tissue injury from administration of vasopressors through peripheral intravenous catheters and central venous catheters. J Crit Care. 2015;30(3):653.e9-17.
Loubani, O. M., & Green, R. S. (2015). A systematic review of extravasation and local tissue injury from administration of vasopressors through peripheral intravenous catheters and central venous catheters. Journal of Critical Care, 30(3), e9-17. https://doi.org/10.1016/j.jcrc.2015.01.014
Loubani OM, Green RS. A Systematic Review of Extravasation and Local Tissue Injury From Administration of Vasopressors Through Peripheral Intravenous Catheters and Central Venous Catheters. J Crit Care. 2015;30(3):653.e9-17. PubMed PMID: 25669592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A systematic review of extravasation and local tissue injury from administration of vasopressors through peripheral intravenous catheters and central venous catheters. AU - Loubani,Osama M, AU - Green,Robert S, Y1 - 2015/01/22/ PY - 2014/11/30/received PY - 2015/01/10/revised PY - 2015/01/15/accepted PY - 2015/2/12/entrez PY - 2015/2/12/pubmed PY - 2015/12/17/medline KW - Adverse effects KW - Central venous catheterization KW - Extravasation of diagnostic and therapeutic materials KW - Intravenous administration KW - Peripheral venous catheterization KW - Vasopressor agents SP - 653.e9 EP - 17 JF - Journal of critical care JO - J Crit Care VL - 30 IS - 3 N2 - PURPOSE: The aim of this study was to collect and describe all published reports of local tissue injury or extravasation from vasopressor administration via either peripheral intravenous (IV) or central venous catheter. METHODS: A systematic search of Medline, Embase, and Cochrane databases was performed from inception through January 2014 for reports of adults who received vasopressor intravenously via peripheral IV or central venous catheter for a therapeutic purpose. We included primary studies or case reports of vasopressor administration that resulted in local tissue injury or extravasation of vasopressor solution. RESULTS: Eighty-five articles with 270 patients met all inclusion criteria. A total of 325 separate local tissue injury and extravasation events were identified, with 318 events resulting from peripheral vasopressor administration and 7 events resulting from central administration. There were 204 local tissue injury events from peripheral administration of vasopressors, with an average duration of infusion of 55.9 hours (±68.1), median time of 24 hours, and range of 0.08 to 528 hours. In most of these events (174/204, 85.3%), the infusion site was located distal to the antecubital or popliteal fossae. CONCLUSIONS: Published data on tissue injury or extravasation from vasopressor administration via peripheral IVs are derived mainly from case reports. Further study is warranted to clarify the safety of vasopressor administration via peripheral IVs. SN - 1557-8615 UR - https://www.unboundmedicine.com/medline/citation/25669592/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0883-9441(15)00033-7 DB - PRIME DP - Unbound Medicine ER -