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Corn oil improves the plasma lipoprotein lipid profile compared with extra-virgin olive oil consumption in men and women with elevated cholesterol: results from a randomized controlled feeding trial.
J Clin Lipidol. 2015 Jan-Feb; 9(1):49-57.JC

Abstract

BACKGROUND

Restricted intakes of saturated and trans-fatty acids is emphasized in heart-healthy diets, and replacement with poly- and monounsaturated fatty acids is encouraged.

OBJECTIVE

To compare the effects of polyunsaturated fatty acid-rich corn oil (CO) and monounsaturated fatty acid-rich extra-virgin olive oil (EVOO) on plasma lipids in men and women (N = 54) with fasting low-density lipoprotein cholesterol (LDL-C) ≥130 mg/dL and <200 mg/dL and triglycerides (TG) ≤350 mg/dL.

METHODS

In a double-blind, randomized, crossover design (21-day treatments, 21-day washout between), 4 tablespoons/day CO or EVOO were provided in 3 servings study product/day (muffin, roll, yogurt) as part of a weight-maintenance diet (∼35% fat, <10% saturated fat, <300 mg cholesterol). Subjects ate breakfast at the clinic every weekday throughout the study. Lunches, dinners, and snacks (and breakfasts on weekends) were provided for consumption away from the clinic.

RESULTS

Baseline mean (standard error) lipids in mg/dL were: LDL-C 153.3 (3.5), total cholesterol (total-C) 225.7 (3.9), non-high-density lipoprotein (non-HDL)-C 178.3 (3.7), HDL-C 47.4 (1.7), total-C/HDL-C 5.0 (0.2), and TG 124.8 (7.2). CO resulted in significantly larger least-squares mean % changes (all P < .001 vs EVOO) from baseline in LDL-C -10.9 vs -3.5, total-C -8.2 vs -1.8, non-HDL-C -9.3 vs -1.6, and total-C/HDL-C -4.4 vs 0.5. TG rose a smaller amount with CO, 3.5 vs 13.0% with EVOO (P = .007). HDL-C responses were not significantly different between conditions (-3.4 vs -1.7%).

CONCLUSION

Consumption of CO in a weight-maintenance, low saturated fat and cholesterol diet resulted in more favorable changes in LDL-C and other atherogenic lipids vs EVOO.

Authors+Show Affiliations

Biofortis Clinical Research, Addison, IL, USA. Electronic address: kmaki@mc-mcr.com.Biofortis Clinical Research, Addison, IL, USA.Biofortis Clinical Research, Addison, IL, USA.Biofortis Clinical Research, Addison, IL, USA.Division of Nutrition, University of Utah, Salt Lake City, UT, USA; Geiger & Associates, LLC, Fort Bridger, WY, USA.Biofortis Clinical Research, Addison, IL, USA.

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25670360

Citation

Maki, Kevin C., et al. "Corn Oil Improves the Plasma Lipoprotein Lipid Profile Compared With Extra-virgin Olive Oil Consumption in Men and Women With Elevated Cholesterol: Results From a Randomized Controlled Feeding Trial." Journal of Clinical Lipidology, vol. 9, no. 1, 2015, pp. 49-57.
Maki KC, Lawless AL, Kelley KM, et al. Corn oil improves the plasma lipoprotein lipid profile compared with extra-virgin olive oil consumption in men and women with elevated cholesterol: results from a randomized controlled feeding trial. J Clin Lipidol. 2015;9(1):49-57.
Maki, K. C., Lawless, A. L., Kelley, K. M., Kaden, V. N., Geiger, C. J., & Dicklin, M. R. (2015). Corn oil improves the plasma lipoprotein lipid profile compared with extra-virgin olive oil consumption in men and women with elevated cholesterol: results from a randomized controlled feeding trial. Journal of Clinical Lipidology, 9(1), 49-57. https://doi.org/10.1016/j.jacl.2014.10.006
Maki KC, et al. Corn Oil Improves the Plasma Lipoprotein Lipid Profile Compared With Extra-virgin Olive Oil Consumption in Men and Women With Elevated Cholesterol: Results From a Randomized Controlled Feeding Trial. J Clin Lipidol. 2015 Jan-Feb;9(1):49-57. PubMed PMID: 25670360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Corn oil improves the plasma lipoprotein lipid profile compared with extra-virgin olive oil consumption in men and women with elevated cholesterol: results from a randomized controlled feeding trial. AU - Maki,Kevin C, AU - Lawless,Andrea L, AU - Kelley,Kathleen M, AU - Kaden,Valerie N, AU - Geiger,Constance J, AU - Dicklin,Mary R, Y1 - 2014/10/23/ PY - 2014/06/18/received PY - 2014/09/10/revised PY - 2014/10/20/accepted PY - 2015/2/12/entrez PY - 2015/2/12/pubmed PY - 2015/10/27/medline KW - Cholesterol KW - Corn oil KW - Lipids KW - Lipoproteins KW - Low-density lipoprotein KW - Monounsaturated fatty acids KW - Olive oil KW - Phytosterols KW - Polyunsaturated fatty acids SP - 49 EP - 57 JF - Journal of clinical lipidology JO - J Clin Lipidol VL - 9 IS - 1 N2 - BACKGROUND: Restricted intakes of saturated and trans-fatty acids is emphasized in heart-healthy diets, and replacement with poly- and monounsaturated fatty acids is encouraged. OBJECTIVE: To compare the effects of polyunsaturated fatty acid-rich corn oil (CO) and monounsaturated fatty acid-rich extra-virgin olive oil (EVOO) on plasma lipids in men and women (N = 54) with fasting low-density lipoprotein cholesterol (LDL-C) ≥130 mg/dL and <200 mg/dL and triglycerides (TG) ≤350 mg/dL. METHODS: In a double-blind, randomized, crossover design (21-day treatments, 21-day washout between), 4 tablespoons/day CO or EVOO were provided in 3 servings study product/day (muffin, roll, yogurt) as part of a weight-maintenance diet (∼35% fat, <10% saturated fat, <300 mg cholesterol). Subjects ate breakfast at the clinic every weekday throughout the study. Lunches, dinners, and snacks (and breakfasts on weekends) were provided for consumption away from the clinic. RESULTS: Baseline mean (standard error) lipids in mg/dL were: LDL-C 153.3 (3.5), total cholesterol (total-C) 225.7 (3.9), non-high-density lipoprotein (non-HDL)-C 178.3 (3.7), HDL-C 47.4 (1.7), total-C/HDL-C 5.0 (0.2), and TG 124.8 (7.2). CO resulted in significantly larger least-squares mean % changes (all P < .001 vs EVOO) from baseline in LDL-C -10.9 vs -3.5, total-C -8.2 vs -1.8, non-HDL-C -9.3 vs -1.6, and total-C/HDL-C -4.4 vs 0.5. TG rose a smaller amount with CO, 3.5 vs 13.0% with EVOO (P = .007). HDL-C responses were not significantly different between conditions (-3.4 vs -1.7%). CONCLUSION: Consumption of CO in a weight-maintenance, low saturated fat and cholesterol diet resulted in more favorable changes in LDL-C and other atherogenic lipids vs EVOO. SN - 1933-2874 UR - https://www.unboundmedicine.com/medline/citation/25670360/Corn_oil_improves_the_plasma_lipoprotein_lipid_profile_compared_with_extra_virgin_olive_oil_consumption_in_men_and_women_with_elevated_cholesterol:_results_from_a_randomized_controlled_feeding_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1933-2874(14)00344-4 DB - PRIME DP - Unbound Medicine ER -