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Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats.
J Med Food. 2015 Aug; 18(8):909-15.JM

Abstract

The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats. After inducement of CCI, significant increases in the number of paw lifts from a cold plate test (cold allodynia) and decreased paw withdrawal threshold in the von Frey hair stimulation test (mechanical allodynia) were observed. However, these cold and mechanical allodynia were markedly alleviated by berberine administration in a dose-dependent manner. Sciatic nerve myeloperoxidase and malondialdehyde activities were also attenuated by berberine administration. Continuous injection for 7 days induced no development of tolerance. The antiallodynic effect of 20 mg/kg berberine was comparable to that of amitriptyline 10 mg/kg. This study demonstrated that berberine could mitigate allodynia induced by CCI, a neuropathic pain model, and it suggested that the anti-inflammatory and antioxidative properties of berberine contributed to the antiallodynic effect in the CCI model.

Authors+Show Affiliations

Department of Anesthesiology and Pain Medicine, Keimyung University School of Medicine , Daegu, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25674823

Citation

Kim, Hyun Jee. "Berberine Ameliorates Allodynia Induced By Chronic Constriction Injury of the Sciatic Nerve in Rats." Journal of Medicinal Food, vol. 18, no. 8, 2015, pp. 909-15.
Kim HJ. Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. J Med Food. 2015;18(8):909-15.
Kim, H. J. (2015). Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. Journal of Medicinal Food, 18(8), 909-15. https://doi.org/10.1089/jmf.2014.3346
Kim HJ. Berberine Ameliorates Allodynia Induced By Chronic Constriction Injury of the Sciatic Nerve in Rats. J Med Food. 2015;18(8):909-15. PubMed PMID: 25674823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Berberine Ameliorates Allodynia Induced by Chronic Constriction Injury of the Sciatic Nerve in Rats. A1 - Kim,Hyun Jee, Y1 - 2015/02/12/ PY - 2015/2/13/entrez PY - 2015/2/13/pubmed PY - 2016/6/29/medline KW - anti-inflammatory agents KW - antioxidants KW - berberine KW - hyperalgesia KW - neuralgia SP - 909 EP - 15 JF - Journal of medicinal food JO - J Med Food VL - 18 IS - 8 N2 - The objective of this study was to investigate whether berberine could ameliorate allodynia induced by chronic constriction injury (CCI) of the sciatic nerve in rats. After inducement of CCI, significant increases in the number of paw lifts from a cold plate test (cold allodynia) and decreased paw withdrawal threshold in the von Frey hair stimulation test (mechanical allodynia) were observed. However, these cold and mechanical allodynia were markedly alleviated by berberine administration in a dose-dependent manner. Sciatic nerve myeloperoxidase and malondialdehyde activities were also attenuated by berberine administration. Continuous injection for 7 days induced no development of tolerance. The antiallodynic effect of 20 mg/kg berberine was comparable to that of amitriptyline 10 mg/kg. This study demonstrated that berberine could mitigate allodynia induced by CCI, a neuropathic pain model, and it suggested that the anti-inflammatory and antioxidative properties of berberine contributed to the antiallodynic effect in the CCI model. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/25674823/Berberine_Ameliorates_Allodynia_Induced_by_Chronic_Constriction_Injury_of_the_Sciatic_Nerve_in_Rats_ L2 - https://www.liebertpub.com/doi/10.1089/jmf.2014.3346?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -