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Role of apomorphine in the treatment of Parkinson's disease.
CNS Drugs. 2015 Feb; 29(2):83-9.CD

Abstract

Current research shows that apomorphine is an effective treatment for symptoms of Parkinson's Disease (PD). The highly lipophilic structure allows apomorphine to cross cell membranes rapidly, leading to the rapid onset of action for on/off symptoms of PD. The use of apomorphine was limited in the past due to peripheral side effects, but with the advent of better delivery systems and medications to control side effects, apomorphine is better tolerated and more widely in use. The major delivery systems are continuous subcutaneous infusions and intermittent subcutaneous injections, but other delivery routes are under investigation. The purpose of this article is to discuss the current use of apomorphine, the current delivery systems and to discuss future research.

Authors+Show Affiliations

University of Texas Health Science Center at Houston, 6410 Fannin Street, Ste 1010, Houston, TX, 77030, USA, Allison.Boyle@uth.tmc.edu.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

25676564

Citation

Boyle, Allison, and William Ondo. "Role of Apomorphine in the Treatment of Parkinson's Disease." CNS Drugs, vol. 29, no. 2, 2015, pp. 83-9.
Boyle A, Ondo W. Role of apomorphine in the treatment of Parkinson's disease. CNS Drugs. 2015;29(2):83-9.
Boyle, A., & Ondo, W. (2015). Role of apomorphine in the treatment of Parkinson's disease. CNS Drugs, 29(2), 83-9. https://doi.org/10.1007/s40263-014-0221-z
Boyle A, Ondo W. Role of Apomorphine in the Treatment of Parkinson's Disease. CNS Drugs. 2015;29(2):83-9. PubMed PMID: 25676564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of apomorphine in the treatment of Parkinson's disease. AU - Boyle,Allison, AU - Ondo,William, PY - 2015/2/14/entrez PY - 2015/2/14/pubmed PY - 2015/11/18/medline SP - 83 EP - 9 JF - CNS drugs JO - CNS Drugs VL - 29 IS - 2 N2 - Current research shows that apomorphine is an effective treatment for symptoms of Parkinson's Disease (PD). The highly lipophilic structure allows apomorphine to cross cell membranes rapidly, leading to the rapid onset of action for on/off symptoms of PD. The use of apomorphine was limited in the past due to peripheral side effects, but with the advent of better delivery systems and medications to control side effects, apomorphine is better tolerated and more widely in use. The major delivery systems are continuous subcutaneous infusions and intermittent subcutaneous injections, but other delivery routes are under investigation. The purpose of this article is to discuss the current use of apomorphine, the current delivery systems and to discuss future research. SN - 1179-1934 UR - https://www.unboundmedicine.com/medline/citation/25676564/Role_of_apomorphine_in_the_treatment_of_Parkinson's_disease_ L2 - https://dx.doi.org/10.1007/s40263-014-0221-z DB - PRIME DP - Unbound Medicine ER -