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Minute perivascular epithelioid cell (PEC) nests in the abdominal lymph nodes--a putative precursor of PEComa.
Pathol Int. 2015 Apr; 65(4):193-6.PI

Abstract

A perivascular epithelioid cell tumor (PEComa) is a peculiar growth defined as a mesenchymal tumor composed of histologically and immunohistochemically distinct perivascular epithelioid cells (PECs). Because neither normal counterparts nor precursor lesions of PEComa have been identified, we examined minute PEC nests, ranged from 0.8 mm to 10 mm, to investigate the possible origin of the PEComa. We examined a total of 80 677 para-aortic and pelvic lymph nodes that were systematically dissected from 1656 patients for gynecological malignancies. The identified lesions were confirmed immunohistochemically with multiple PEC markers, including smooth muscle actin, HMB45, melan-A, MiTF, ER and PgR. A total of 66 minute PEC nests were found in 21 patients (1.3% of the total population) with an average frequency of 3.1 lesions per patient. In cases of multiple involvement, 11 of 13 nests were located at the same level of multiple lymph node or on continuous levels. The lesions were preferentially distributed at the level of para-aortic and high pelvic lymph nodes. All nests were positive for actin and HMB45, whereas the other markers were positive with varying frequencies. The minute PEC nests may be associated with the possible normal counterpart of PEComas.

Authors+Show Affiliations

Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25677636

Citation

Nagasaka, Toru, et al. "Minute Perivascular Epithelioid Cell (PEC) Nests in the Abdominal Lymph Nodes--a Putative Precursor of PEComa." Pathology International, vol. 65, no. 4, 2015, pp. 193-6.
Nagasaka T, Murakami Y, Sasaki E, et al. Minute perivascular epithelioid cell (PEC) nests in the abdominal lymph nodes--a putative precursor of PEComa. Pathol Int. 2015;65(4):193-6.
Nagasaka, T., Murakami, Y., Sasaki, E., Hosoda, W., Nakanishi, T., & Yatabe, Y. (2015). Minute perivascular epithelioid cell (PEC) nests in the abdominal lymph nodes--a putative precursor of PEComa. Pathology International, 65(4), 193-6. https://doi.org/10.1111/pin.12262
Nagasaka T, et al. Minute Perivascular Epithelioid Cell (PEC) Nests in the Abdominal Lymph Nodes--a Putative Precursor of PEComa. Pathol Int. 2015;65(4):193-6. PubMed PMID: 25677636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Minute perivascular epithelioid cell (PEC) nests in the abdominal lymph nodes--a putative precursor of PEComa. AU - Nagasaka,Toru, AU - Murakami,Yoshiko, AU - Sasaki,Eiichi, AU - Hosoda,Waki, AU - Nakanishi,Toru, AU - Yatabe,Yasushi, Y1 - 2015/02/10/ PY - 2014/12/03/received PY - 2015/01/12/accepted PY - 2015/2/14/entrez PY - 2015/2/14/pubmed PY - 2016/4/16/medline KW - PEComa KW - angiomyolipoma KW - lymphangioleiomyomatosis KW - perivascular epithelioid cell SP - 193 EP - 6 JF - Pathology international JO - Pathol. Int. VL - 65 IS - 4 N2 - A perivascular epithelioid cell tumor (PEComa) is a peculiar growth defined as a mesenchymal tumor composed of histologically and immunohistochemically distinct perivascular epithelioid cells (PECs). Because neither normal counterparts nor precursor lesions of PEComa have been identified, we examined minute PEC nests, ranged from 0.8 mm to 10 mm, to investigate the possible origin of the PEComa. We examined a total of 80 677 para-aortic and pelvic lymph nodes that were systematically dissected from 1656 patients for gynecological malignancies. The identified lesions were confirmed immunohistochemically with multiple PEC markers, including smooth muscle actin, HMB45, melan-A, MiTF, ER and PgR. A total of 66 minute PEC nests were found in 21 patients (1.3% of the total population) with an average frequency of 3.1 lesions per patient. In cases of multiple involvement, 11 of 13 nests were located at the same level of multiple lymph node or on continuous levels. The lesions were preferentially distributed at the level of para-aortic and high pelvic lymph nodes. All nests were positive for actin and HMB45, whereas the other markers were positive with varying frequencies. The minute PEC nests may be associated with the possible normal counterpart of PEComas. SN - 1440-1827 UR - https://www.unboundmedicine.com/medline/citation/25677636/Minute_perivascular_epithelioid_cell__PEC__nests_in_the_abdominal_lymph_nodes__a_putative_precursor_of_PEComa_ L2 - https://doi.org/10.1111/pin.12262 DB - PRIME DP - Unbound Medicine ER -