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Consumption of beer and colorectal cancer incidence: a meta-analysis of observational studies.
Cancer Causes Control 2015; 26(4):549-60CC

Abstract

BACKGROUND

Several meta-analyses and reports from the World Cancer Research Fund supported a risk association between alcohol consumption and colorectal cancer (CRC). However, the association for beer consumption, the common type of alcoholic beverage, remains unclear.

METHODS

We identified studies by a literature search of PUBMED and EMBASE through 30 June 2014. Summary relative risks (SRRs) with their 95% CIs were calculated with a fixed or random effects model.

RESULTS

Twelve case-control and nine cohort studies were included. Compared with non-alcohol drinkers or non-beer drinkers, any beer drinkers were associated with an increased risk of CRC (SRR = 1.20, 95% CI, 1.06-1.37; p(heterogeneity) <0.001, I(2) = 73.3%), which was stronger in the rectum than in the colon. The categorical meta-analysis indicated that heavy (≥ 2 drinks/day) beer drinking was related to increased risk of CRC (SRR = 1.37, 95% CI 1.26-1.49), while light or moderate beer drinking was not. The dose-response analysis demonstrated that an increase of one drink per day in beer consumption was related to an increased risk of CRC (SRR = 1.13, 95% CI, 1.06-1.21). There was evidence of a potential nonlinear association between beer intake and CRC incidence (p = 0.002 for nonlinearity).

CONCLUSIONS

The results from this meta-analysis suggest that heavy (≥ 2 drinks/day) beer drinking may be associated with increased CRC risk. More researches with improved control of confounding and actual measurement of beer consumption are needed to confirm these findings.

Authors+Show Affiliations

Department of Colorectal Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dongfang Road, Pudong New District, 200127, Shanghai, China.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

25677844

Citation

Zhang, Cheng, and Min Zhong. "Consumption of Beer and Colorectal Cancer Incidence: a Meta-analysis of Observational Studies." Cancer Causes & Control : CCC, vol. 26, no. 4, 2015, pp. 549-60.
Zhang C, Zhong M. Consumption of beer and colorectal cancer incidence: a meta-analysis of observational studies. Cancer Causes Control. 2015;26(4):549-60.
Zhang, C., & Zhong, M. (2015). Consumption of beer and colorectal cancer incidence: a meta-analysis of observational studies. Cancer Causes & Control : CCC, 26(4), pp. 549-60. doi:10.1007/s10552-015-0532-5.
Zhang C, Zhong M. Consumption of Beer and Colorectal Cancer Incidence: a Meta-analysis of Observational Studies. Cancer Causes Control. 2015;26(4):549-60. PubMed PMID: 25677844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of beer and colorectal cancer incidence: a meta-analysis of observational studies. AU - Zhang,Cheng, AU - Zhong,Min, Y1 - 2015/02/13/ PY - 2014/11/08/received PY - 2015/02/05/accepted PY - 2015/2/14/entrez PY - 2015/2/14/pubmed PY - 2016/3/22/medline SP - 549 EP - 60 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 26 IS - 4 N2 - BACKGROUND: Several meta-analyses and reports from the World Cancer Research Fund supported a risk association between alcohol consumption and colorectal cancer (CRC). However, the association for beer consumption, the common type of alcoholic beverage, remains unclear. METHODS: We identified studies by a literature search of PUBMED and EMBASE through 30 June 2014. Summary relative risks (SRRs) with their 95% CIs were calculated with a fixed or random effects model. RESULTS: Twelve case-control and nine cohort studies were included. Compared with non-alcohol drinkers or non-beer drinkers, any beer drinkers were associated with an increased risk of CRC (SRR = 1.20, 95% CI, 1.06-1.37; p(heterogeneity) <0.001, I(2) = 73.3%), which was stronger in the rectum than in the colon. The categorical meta-analysis indicated that heavy (≥ 2 drinks/day) beer drinking was related to increased risk of CRC (SRR = 1.37, 95% CI 1.26-1.49), while light or moderate beer drinking was not. The dose-response analysis demonstrated that an increase of one drink per day in beer consumption was related to an increased risk of CRC (SRR = 1.13, 95% CI, 1.06-1.21). There was evidence of a potential nonlinear association between beer intake and CRC incidence (p = 0.002 for nonlinearity). CONCLUSIONS: The results from this meta-analysis suggest that heavy (≥ 2 drinks/day) beer drinking may be associated with increased CRC risk. More researches with improved control of confounding and actual measurement of beer consumption are needed to confirm these findings. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/25677844/Consumption_of_beer_and_colorectal_cancer_incidence:_a_meta_analysis_of_observational_studies_ L2 - https://doi.org/10.1007/s10552-015-0532-5 DB - PRIME DP - Unbound Medicine ER -