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Treatment of reflux esophagitis with H2-blockers, antacids and prokinetic drugs. An analysis of randomized clinical trials.
Scand J Gastroenterol Suppl 1989; 156:25-36SJ

Abstract

Randomized clinical trials comparing H2-receptor antagonists, antacids, antacid/alginate and prokinetic drugs with placebo and other substances were analyzed. Symptomatic improvement has been shown for H2-receptor antagonists, antacids in very high doses and prokinetic drugs. H2-receptor antagonists, the present mainstay of reflux therapy, improve esophagitis, but they are insufficient in the treatment of severe esophagitis where omeprazole may become the therapy of choice. The evidence is weak that antacids, antacid/alginate, metoclopramide and domperidone heal esophagitis.

Authors+Show Affiliations

Department of Internal Medicine, Triemli Hospital, Zurich, Switzerland.

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

2568015

Citation

Koelz, H R.. "Treatment of Reflux Esophagitis With H2-blockers, Antacids and Prokinetic Drugs. an Analysis of Randomized Clinical Trials." Scandinavian Journal of Gastroenterology. Supplement, vol. 156, 1989, pp. 25-36.
Koelz HR. Treatment of reflux esophagitis with H2-blockers, antacids and prokinetic drugs. An analysis of randomized clinical trials. Scand J Gastroenterol Suppl. 1989;156:25-36.
Koelz, H. R. (1989). Treatment of reflux esophagitis with H2-blockers, antacids and prokinetic drugs. An analysis of randomized clinical trials. Scandinavian Journal of Gastroenterology. Supplement, 156, pp. 25-36.
Koelz HR. Treatment of Reflux Esophagitis With H2-blockers, Antacids and Prokinetic Drugs. an Analysis of Randomized Clinical Trials. Scand J Gastroenterol Suppl. 1989;156:25-36. PubMed PMID: 2568015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of reflux esophagitis with H2-blockers, antacids and prokinetic drugs. An analysis of randomized clinical trials. A1 - Koelz,H R, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 25 EP - 36 JF - Scandinavian journal of gastroenterology. Supplement JO - Scand. J. Gastroenterol. Suppl. VL - 156 N2 - Randomized clinical trials comparing H2-receptor antagonists, antacids, antacid/alginate and prokinetic drugs with placebo and other substances were analyzed. Symptomatic improvement has been shown for H2-receptor antagonists, antacids in very high doses and prokinetic drugs. H2-receptor antagonists, the present mainstay of reflux therapy, improve esophagitis, but they are insufficient in the treatment of severe esophagitis where omeprazole may become the therapy of choice. The evidence is weak that antacids, antacid/alginate, metoclopramide and domperidone heal esophagitis. SN - 0085-5928 UR - https://www.unboundmedicine.com/medline/citation/2568015/Treatment_of_reflux_esophagitis_with_H2_blockers_antacids_and_prokinetic_drugs__An_analysis_of_randomized_clinical_trials_ L2 - https://www.lens.org/lens/search?q=citation_id:2568015 DB - PRIME DP - Unbound Medicine ER -