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Association of Depression With Selenium Deficiency and Nutritional Markers in the Patients With End-Stage Renal Disease on Hemodialysis.
J Ren Nutr 2015; 25(4):381-7JR

Abstract

OBJECTIVE

Depression is considered as the most common psychological problem in hemodialysis (HD) patients. As there is little evidence regarding the association of depression with serum selenium level as an antioxidant in these patients, the current survey investigates the possible relationship between depression and nutritional status including serum selenium levels.

DESIGN

Cross-sectional study.

SETTING AND SUBJECTS

A total of 110 HD patients and 40 healthy controls were enrolled in the study. The patients were in the age range of 18 to 85 years, who had been on hemodialysis for at least 3 months without any acute illness.

MAIN OUTCOME MEASURE

Beck Depression Inventory was used for assessing the severity of depression. Malnutrition was evaluated through subjective global assessment (SGA) and malnutrition inflammation score (MIS). Serum selenium levels and routine laboratory markers were measured from fasting samples.

RESULTS

Sixty-two percent of the patients had some degree of depression based on Beck Depression Inventory score. HD patients were considered to be selenium deficient after comparing the mean value of serum selenium between the patients and controls (P < .001). No significant difference was found in serum selenium levels between depressed HD patients and the rest of patients without depression. The mean level of SGA and MIS in the depressed patients was significantly higher than the rest of patients (P = .03 and P = .04, respectively). Also lower levels of hemoglobin and serum albumin were significantly seen in depressed patients compared with nondepressed ones (P = .004 and P = .04, respectively).

CONCLUSIONS

Although the HD patients in this study were selenium deficient, no significant association was found between depression and selenium. In addition, depression was more prevalent in malnourished HD patients with higher SGA and MIS scores and lower serum albumin and hemoglobin levels.

Authors+Show Affiliations

Department of Clinical Nutrition, Shiraz School of Nutrition & Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.Department of Clinical Nutrition, Shiraz School of Nutrition & Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: zhmazloom@gmail.com.Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25680525

Citation

Ekramzadeh, Maryam, et al. "Association of Depression With Selenium Deficiency and Nutritional Markers in the Patients With End-Stage Renal Disease On Hemodialysis." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 25, no. 4, 2015, pp. 381-7.
Ekramzadeh M, Mazloom Z, Sagheb M. Association of Depression With Selenium Deficiency and Nutritional Markers in the Patients With End-Stage Renal Disease on Hemodialysis. J Ren Nutr. 2015;25(4):381-7.
Ekramzadeh, M., Mazloom, Z., & Sagheb, M. (2015). Association of Depression With Selenium Deficiency and Nutritional Markers in the Patients With End-Stage Renal Disease on Hemodialysis. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 25(4), pp. 381-7. doi:10.1053/j.jrn.2014.12.005.
Ekramzadeh M, Mazloom Z, Sagheb M. Association of Depression With Selenium Deficiency and Nutritional Markers in the Patients With End-Stage Renal Disease On Hemodialysis. J Ren Nutr. 2015;25(4):381-7. PubMed PMID: 25680525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Depression With Selenium Deficiency and Nutritional Markers in the Patients With End-Stage Renal Disease on Hemodialysis. AU - Ekramzadeh,Maryam, AU - Mazloom,Zohreh, AU - Sagheb,Mohammadmahdi, Y1 - 2015/02/11/ PY - 2014/10/07/received PY - 2014/11/23/revised PY - 2014/12/16/accepted PY - 2015/2/15/entrez PY - 2015/2/15/pubmed PY - 2016/4/5/medline SP - 381 EP - 7 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 25 IS - 4 N2 - OBJECTIVE: Depression is considered as the most common psychological problem in hemodialysis (HD) patients. As there is little evidence regarding the association of depression with serum selenium level as an antioxidant in these patients, the current survey investigates the possible relationship between depression and nutritional status including serum selenium levels. DESIGN: Cross-sectional study. SETTING AND SUBJECTS: A total of 110 HD patients and 40 healthy controls were enrolled in the study. The patients were in the age range of 18 to 85 years, who had been on hemodialysis for at least 3 months without any acute illness. MAIN OUTCOME MEASURE: Beck Depression Inventory was used for assessing the severity of depression. Malnutrition was evaluated through subjective global assessment (SGA) and malnutrition inflammation score (MIS). Serum selenium levels and routine laboratory markers were measured from fasting samples. RESULTS: Sixty-two percent of the patients had some degree of depression based on Beck Depression Inventory score. HD patients were considered to be selenium deficient after comparing the mean value of serum selenium between the patients and controls (P < .001). No significant difference was found in serum selenium levels between depressed HD patients and the rest of patients without depression. The mean level of SGA and MIS in the depressed patients was significantly higher than the rest of patients (P = .03 and P = .04, respectively). Also lower levels of hemoglobin and serum albumin were significantly seen in depressed patients compared with nondepressed ones (P = .004 and P = .04, respectively). CONCLUSIONS: Although the HD patients in this study were selenium deficient, no significant association was found between depression and selenium. In addition, depression was more prevalent in malnourished HD patients with higher SGA and MIS scores and lower serum albumin and hemoglobin levels. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/25680525/Association_of_Depression_With_Selenium_Deficiency_and_Nutritional_Markers_in_the_Patients_With_End_Stage_Renal_Disease_on_Hemodialysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(14)00258-1 DB - PRIME DP - Unbound Medicine ER -