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Molecular epidemiology of coxsackievirus A6 associated with outbreaks of hand, foot, and mouth disease in Tianjin, China, in 2013.
Arch Virol. 2015 Apr; 160(4):1097-104.AV

Abstract

Since 2008, Mainland China has undergone widespread outbreaks of hand, foot, and mouth disease (HFMD). In order to determine the characteristics of epidemics and enteroviruses (EV) associated with HFMD in Tianjin, in northern China, epidemiological and virological data from routine surveillance were collected and analyzed. In Tianjin, a persistent epidemic of HFMD was demonstrated during 2008-2013, involving 102,705 mild, 179 severe, and 16 fatal cases. Overall, 8234 specimens were collected from 7829 HFMD patients for EV detection during 2008-2013. Enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) were the dominant serotypes during 2008-2012, and they were replaced by CV-A6 as the major causative agent in 2013. Phylogenetic analysis based on complete VP1 nucleotide sequences revealed that multiple CV-A6 lineages co-circulated in Tianjin, which grouped together with strains from China and other countries and split into two distinct clusters (clusters 1 and 2). Most Tianjin strains grouped in cluster 1 and were closely related to strains from several eastern and southern provinces of China during 2012 and 2013. Estimates from Bayesian MCMC analysis suggested that multiple lineages had been transmitted silently before the outbreaks at an estimated evolutionary rate of 4.10 × 10(-3) substitutions per site per year without a specific distribution of rate variances among lineages. The sudden outbreak of CV-A6 in Tianjin during 2013 is attributed to indigenous CV-A6 lineages, which were linked to the wide spread of endemic strains around eastern and southern China.

Authors+Show Affiliations

Key Laboratory of Medical Virology of Ministry of Health, Chinese Center for Disease Control and Prevention, Institute for Viral Disease Control and Prevention, 155 Changbai Road, Beijing, 102206, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25680566

Citation

Tan, Xiaojuan, et al. "Molecular Epidemiology of Coxsackievirus A6 Associated With Outbreaks of Hand, Foot, and Mouth Disease in Tianjin, China, in 2013." Archives of Virology, vol. 160, no. 4, 2015, pp. 1097-104.
Tan X, Li L, Zhang B, et al. Molecular epidemiology of coxsackievirus A6 associated with outbreaks of hand, foot, and mouth disease in Tianjin, China, in 2013. Arch Virol. 2015;160(4):1097-104.
Tan, X., Li, L., Zhang, B., Jorba, J., Su, X., Ji, T., Yang, D., Lv, L., Li, J., & Xu, W. (2015). Molecular epidemiology of coxsackievirus A6 associated with outbreaks of hand, foot, and mouth disease in Tianjin, China, in 2013. Archives of Virology, 160(4), 1097-104. https://doi.org/10.1007/s00705-015-2340-3
Tan X, et al. Molecular Epidemiology of Coxsackievirus A6 Associated With Outbreaks of Hand, Foot, and Mouth Disease in Tianjin, China, in 2013. Arch Virol. 2015;160(4):1097-104. PubMed PMID: 25680566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular epidemiology of coxsackievirus A6 associated with outbreaks of hand, foot, and mouth disease in Tianjin, China, in 2013. AU - Tan,Xiaojuan, AU - Li,Li, AU - Zhang,Baomin, AU - Jorba,Jaume, AU - Su,Xu, AU - Ji,Tianjiao, AU - Yang,Dongjing, AU - Lv,Likun, AU - Li,Jiameng, AU - Xu,Wenbo, Y1 - 2015/02/15/ PY - 2014/10/21/received PY - 2015/01/14/accepted PY - 2015/2/15/entrez PY - 2015/2/15/pubmed PY - 2015/5/27/medline SP - 1097 EP - 104 JF - Archives of virology JO - Arch Virol VL - 160 IS - 4 N2 - Since 2008, Mainland China has undergone widespread outbreaks of hand, foot, and mouth disease (HFMD). In order to determine the characteristics of epidemics and enteroviruses (EV) associated with HFMD in Tianjin, in northern China, epidemiological and virological data from routine surveillance were collected and analyzed. In Tianjin, a persistent epidemic of HFMD was demonstrated during 2008-2013, involving 102,705 mild, 179 severe, and 16 fatal cases. Overall, 8234 specimens were collected from 7829 HFMD patients for EV detection during 2008-2013. Enterovirus 71 (EV-A71) and coxsackievirus A16 (CV-A16) were the dominant serotypes during 2008-2012, and they were replaced by CV-A6 as the major causative agent in 2013. Phylogenetic analysis based on complete VP1 nucleotide sequences revealed that multiple CV-A6 lineages co-circulated in Tianjin, which grouped together with strains from China and other countries and split into two distinct clusters (clusters 1 and 2). Most Tianjin strains grouped in cluster 1 and were closely related to strains from several eastern and southern provinces of China during 2012 and 2013. Estimates from Bayesian MCMC analysis suggested that multiple lineages had been transmitted silently before the outbreaks at an estimated evolutionary rate of 4.10 × 10(-3) substitutions per site per year without a specific distribution of rate variances among lineages. The sudden outbreak of CV-A6 in Tianjin during 2013 is attributed to indigenous CV-A6 lineages, which were linked to the wide spread of endemic strains around eastern and southern China. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/25680566/Molecular_epidemiology_of_coxsackievirus_A6_associated_with_outbreaks_of_hand_foot_and_mouth_disease_in_Tianjin_China_in_2013_ L2 - https://dx.doi.org/10.1007/s00705-015-2340-3 DB - PRIME DP - Unbound Medicine ER -