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Substance use disorders in schizophrenia, bipolar disorder, and depressive illness: a registry-based study.
Soc Psychiatry Psychiatr Epidemiol. 2015 Aug; 50(8):1267-76.SP

Abstract

PURPOSE

To compare the prevalence and pattern of comorbid substance use disorders (SUD) between patients with schizophrenia, bipolar disorder, and depressive illness.

METHODS

Data on presence of alcohol use disorder (AUD) and non-alcohol drug use disorder (DUD) were retrieved from the Norwegian Patient Register for individuals born between 1950 and 1989 who in the period 2009-2013 were diagnosed with schizophrenia, bipolar disorder or depressive illness according to the 10th version of the WHO International Classification of Diseases. The prevalence of AUD only, DUD only, or both was compared between men and women across age and diagnostic groups.

RESULTS

The prevalence of SUD was 25.1 % in schizophrenia (AUD: 4.6 %, DUD: 15.6 %, AUD and DUD: 4.9 %), 20.1 % in bipolar disorder (AUD: 8.1 %, DUD: 7.6 %, AUD and DUD: 4.4 %), and 10.9 % in depressive illness (AUD: 4.4 %, DUD: 4.3 %, AUD and DUD: 2.2 %). Middle-aged men with bipolar disorder had the highest prevalence of AUD (19.1 %) and young men with schizophrenia had the highest prevalence of DUD (29.6 %). Of the specific DUDs, all but sedative use disorder were more prevalent in schizophrenia than the other groups. Cannabis and stimulant use disorder was found among 8.8 and 8.9 %, respectively, of the men with schizophrenia.

CONCLUSIONS

The alarmingly high prevalence of DUD among young patients with severe mental disorders should encourage preventive efforts to reduce illicit drug use in the adolescent population.

Authors+Show Affiliations

Norwegian Institute of Public Health, P.O. Box 4404, Nydalen, 0403, Oslo, Norway, ragnar.nesvag@fhi.no.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25680837

Citation

Nesvåg, Ragnar, et al. "Substance Use Disorders in Schizophrenia, Bipolar Disorder, and Depressive Illness: a Registry-based Study." Social Psychiatry and Psychiatric Epidemiology, vol. 50, no. 8, 2015, pp. 1267-76.
Nesvåg R, Knudsen GP, Bakken IJ, et al. Substance use disorders in schizophrenia, bipolar disorder, and depressive illness: a registry-based study. Soc Psychiatry Psychiatr Epidemiol. 2015;50(8):1267-76.
Nesvåg, R., Knudsen, G. P., Bakken, I. J., Høye, A., Ystrom, E., Surén, P., Reneflot, A., Stoltenberg, C., & Reichborn-Kjennerud, T. (2015). Substance use disorders in schizophrenia, bipolar disorder, and depressive illness: a registry-based study. Social Psychiatry and Psychiatric Epidemiology, 50(8), 1267-76. https://doi.org/10.1007/s00127-015-1025-2
Nesvåg R, et al. Substance Use Disorders in Schizophrenia, Bipolar Disorder, and Depressive Illness: a Registry-based Study. Soc Psychiatry Psychiatr Epidemiol. 2015;50(8):1267-76. PubMed PMID: 25680837.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Substance use disorders in schizophrenia, bipolar disorder, and depressive illness: a registry-based study. AU - Nesvåg,Ragnar, AU - Knudsen,Gun Peggy, AU - Bakken,Inger Johanne, AU - Høye,Anne, AU - Ystrom,Eivind, AU - Surén,Pål, AU - Reneflot,Anne, AU - Stoltenberg,Camilla, AU - Reichborn-Kjennerud,Ted, Y1 - 2015/02/14/ PY - 2014/08/04/received PY - 2015/02/09/accepted PY - 2015/2/15/entrez PY - 2015/2/15/pubmed PY - 2015/11/3/medline SP - 1267 EP - 76 JF - Social psychiatry and psychiatric epidemiology JO - Soc Psychiatry Psychiatr Epidemiol VL - 50 IS - 8 N2 - PURPOSE: To compare the prevalence and pattern of comorbid substance use disorders (SUD) between patients with schizophrenia, bipolar disorder, and depressive illness. METHODS: Data on presence of alcohol use disorder (AUD) and non-alcohol drug use disorder (DUD) were retrieved from the Norwegian Patient Register for individuals born between 1950 and 1989 who in the period 2009-2013 were diagnosed with schizophrenia, bipolar disorder or depressive illness according to the 10th version of the WHO International Classification of Diseases. The prevalence of AUD only, DUD only, or both was compared between men and women across age and diagnostic groups. RESULTS: The prevalence of SUD was 25.1 % in schizophrenia (AUD: 4.6 %, DUD: 15.6 %, AUD and DUD: 4.9 %), 20.1 % in bipolar disorder (AUD: 8.1 %, DUD: 7.6 %, AUD and DUD: 4.4 %), and 10.9 % in depressive illness (AUD: 4.4 %, DUD: 4.3 %, AUD and DUD: 2.2 %). Middle-aged men with bipolar disorder had the highest prevalence of AUD (19.1 %) and young men with schizophrenia had the highest prevalence of DUD (29.6 %). Of the specific DUDs, all but sedative use disorder were more prevalent in schizophrenia than the other groups. Cannabis and stimulant use disorder was found among 8.8 and 8.9 %, respectively, of the men with schizophrenia. CONCLUSIONS: The alarmingly high prevalence of DUD among young patients with severe mental disorders should encourage preventive efforts to reduce illicit drug use in the adolescent population. SN - 1433-9285 UR - https://www.unboundmedicine.com/medline/citation/25680837/Substance_use_disorders_in_schizophrenia_bipolar_disorder_and_depressive_illness:_a_registry_based_study_ L2 - https://dx.doi.org/10.1007/s00127-015-1025-2 DB - PRIME DP - Unbound Medicine ER -