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Anti-inflammatory activities of cardamonin from Alpinia katsumadai through heme oxygenase-1 induction and inhibition of NF-κB and MAPK signaling pathway in the carrageenan-induced paw edema.
Int Immunopharmacol. 2015 Apr; 25(2):332-9.II

Abstract

Cardamonin is a chalcone isolated from Alpinia katsumadai. This study is aimed to evaluate treatment of cardamonin decreased the paw edema at the 5th hour after λ-carrageenan (Carr) administration and increased the activities of catalase (CAT) and superoxide dismutase (SOD) in the anti-inflammatory test. We also demonstrated that cardamonin significantly attenuated the malondialdehyde (MDA) level in the edema paw at the 5th hour after Carr injection. Cardamonin decreased the nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 levels on the serum level at the 5th hour after Carr injection. Western blotting revealed that cardamonin decreased Carr-induced inducible nitric oxide synthase (iNOS), cycloxyclase (COX-2), nuclear factor-κB (NF-κB) and MAPK [extracellular signal-regulated protein kinase (ERK), c-Jun NH(2)-terminal kinase (JNK), p38] expressions and increased heme oxygenase-1 (HO-1) expressions at the 5th hour in the edema paw. The anti-inflammatory mechanisms of cardamonin might be related to the decrease in the level of MDA, iNOS, COX-2, NF-κB, and MAPK and induction of the HO-1 expression in the edema paw via increasing the activities of CAT and SOD in the edema paw through the suppression of NO, TNF-α, IL-1β, and IL-6.

Authors+Show Affiliations

School of Pharmacy, Zhejiang Medical College, Zhejiang, PR China.School of Pharmacy, China Medical University, Taichung, Taiwan.Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan. Electronic address: dengjs@asia.edu.tw.School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung, Taiwan. Electronic address: gjhuang@mail.cmu.edu.tw.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25681284

Citation

Li, Yuan-Yuan, et al. "Anti-inflammatory Activities of Cardamonin From Alpinia Katsumadai Through Heme Oxygenase-1 Induction and Inhibition of NF-κB and MAPK Signaling Pathway in the Carrageenan-induced Paw Edema." International Immunopharmacology, vol. 25, no. 2, 2015, pp. 332-9.
Li YY, Huang SS, Lee MM, et al. Anti-inflammatory activities of cardamonin from Alpinia katsumadai through heme oxygenase-1 induction and inhibition of NF-κB and MAPK signaling pathway in the carrageenan-induced paw edema. Int Immunopharmacol. 2015;25(2):332-9.
Li, Y. Y., Huang, S. S., Lee, M. M., Deng, J. S., & Huang, G. J. (2015). Anti-inflammatory activities of cardamonin from Alpinia katsumadai through heme oxygenase-1 induction and inhibition of NF-κB and MAPK signaling pathway in the carrageenan-induced paw edema. International Immunopharmacology, 25(2), 332-9. https://doi.org/10.1016/j.intimp.2015.02.002
Li YY, et al. Anti-inflammatory Activities of Cardamonin From Alpinia Katsumadai Through Heme Oxygenase-1 Induction and Inhibition of NF-κB and MAPK Signaling Pathway in the Carrageenan-induced Paw Edema. Int Immunopharmacol. 2015;25(2):332-9. PubMed PMID: 25681284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory activities of cardamonin from Alpinia katsumadai through heme oxygenase-1 induction and inhibition of NF-κB and MAPK signaling pathway in the carrageenan-induced paw edema. AU - Li,Yuan-Yuan, AU - Huang,Shyh-Shyun, AU - Lee,Min-Min, AU - Deng,Jeng-Shyan, AU - Huang,Guan-Jhong, Y1 - 2015/02/11/ PY - 2014/10/02/received PY - 2015/01/19/revised PY - 2015/02/02/accepted PY - 2015/2/15/entrez PY - 2015/2/15/pubmed PY - 2016/1/5/medline KW - Anti-inflammation KW - Cardamonin KW - Chinese medicine KW - HO-1 KW - MAPK KW - NO SP - 332 EP - 9 JF - International immunopharmacology JO - Int Immunopharmacol VL - 25 IS - 2 N2 - Cardamonin is a chalcone isolated from Alpinia katsumadai. This study is aimed to evaluate treatment of cardamonin decreased the paw edema at the 5th hour after λ-carrageenan (Carr) administration and increased the activities of catalase (CAT) and superoxide dismutase (SOD) in the anti-inflammatory test. We also demonstrated that cardamonin significantly attenuated the malondialdehyde (MDA) level in the edema paw at the 5th hour after Carr injection. Cardamonin decreased the nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 levels on the serum level at the 5th hour after Carr injection. Western blotting revealed that cardamonin decreased Carr-induced inducible nitric oxide synthase (iNOS), cycloxyclase (COX-2), nuclear factor-κB (NF-κB) and MAPK [extracellular signal-regulated protein kinase (ERK), c-Jun NH(2)-terminal kinase (JNK), p38] expressions and increased heme oxygenase-1 (HO-1) expressions at the 5th hour in the edema paw. The anti-inflammatory mechanisms of cardamonin might be related to the decrease in the level of MDA, iNOS, COX-2, NF-κB, and MAPK and induction of the HO-1 expression in the edema paw via increasing the activities of CAT and SOD in the edema paw through the suppression of NO, TNF-α, IL-1β, and IL-6. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/25681284/Anti_inflammatory_activities_of_cardamonin_from_Alpinia_katsumadai_through_heme_oxygenase_1_induction_and_inhibition_of_NF_κB_and_MAPK_signaling_pathway_in_the_carrageenan_induced_paw_edema_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(15)00048-X DB - PRIME DP - Unbound Medicine ER -