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Epidemiology of alcoholic liver disease in Denmark 2006-2011: a population-based study.
Alcohol Alcohol. 2015 May; 50(3):352-7.AA

Abstract

AIMS

To describe incidence, prevalence, hospitalization rates and survival for alcoholic liver disease (ALD) in Denmark 2006-2011.

METHODS

Using nationwide healthcare registries we identified all Danish residents with a hospital diagnosis of ALD and computed standardized incidence, prevalence, and hospitalization rates in 2006-2011, age- and birth cohort-specific incidence for the 1930-1974 birth cohorts, and 1- and 5-year survival.

RESULTS

In 2006-2011, the overall standardized ALD incidence decreased from 343 to 311 per 1,000,000 population per year. ALD incidence increased among women aged 65 years or older, but decreased in younger persons and men. Persons born in 1950-1959 had higher age-specific incidence than earlier and later birth cohorts. The prevalence (0.2% of the Danish adult population) and hospitalization rate were constant. The 1- and 5-year survival were 43 and 70%, respectively.

CONCLUSION

In Denmark, persons born in 1950-1959 have had the highest age-specific incidence. The overall ALD incidence has been decreasing (along with per capita consumption). Despite increases in affordability during the study period, Denmark did not experience the increase in ALD seen, for example, in the UK. It is possible that this is due to the greater impact of government recommendations on safer drinking in Denmark than the UK.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Deleuran T
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark thomas.deleuran@clin.au.dk.
Vilstrup H
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Becker U
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark Gastrounit, Medical Division, Copenhagen University Hospital Hvidovre, Copenhagen, Denmark.
Jepsen P
Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.

MeSH

AdultAge DistributionAgedAged, 80 and overDenmarkFatty Liver, AlcoholicFemaleHepatitis, AlcoholicHospitalizationHumansIncidenceLiver Cirrhosis, AlcoholicLiver Diseases, AlcoholicMaleMiddle AgedPrevalenceRegistriesSex Distribution

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25681463

Citation

Deleuran, Thomas, et al. "Epidemiology of Alcoholic Liver Disease in Denmark 2006-2011: a Population-based Study." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 50, no. 3, 2015, pp. 352-7.
Deleuran T, Vilstrup H, Becker U, et al. Epidemiology of alcoholic liver disease in Denmark 2006-2011: a population-based study. Alcohol Alcohol. 2015;50(3):352-7.
Deleuran, T., Vilstrup, H., Becker, U., & Jepsen, P. (2015). Epidemiology of alcoholic liver disease in Denmark 2006-2011: a population-based study. Alcohol and Alcoholism (Oxford, Oxfordshire), 50(3), 352-7. https://doi.org/10.1093/alcalc/agv003
Deleuran T, et al. Epidemiology of Alcoholic Liver Disease in Denmark 2006-2011: a Population-based Study. Alcohol Alcohol. 2015;50(3):352-7. PubMed PMID: 25681463.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of alcoholic liver disease in Denmark 2006-2011: a population-based study. AU - Deleuran,Thomas, AU - Vilstrup,Hendrik, AU - Becker,Ulrik, AU - Jepsen,Peter, Y1 - 2015/02/13/ PY - 2014/10/13/received PY - 2015/01/16/accepted PY - 2015/2/15/entrez PY - 2015/2/15/pubmed PY - 2016/1/7/medline SP - 352 EP - 7 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol VL - 50 IS - 3 N2 - AIMS: To describe incidence, prevalence, hospitalization rates and survival for alcoholic liver disease (ALD) in Denmark 2006-2011. METHODS: Using nationwide healthcare registries we identified all Danish residents with a hospital diagnosis of ALD and computed standardized incidence, prevalence, and hospitalization rates in 2006-2011, age- and birth cohort-specific incidence for the 1930-1974 birth cohorts, and 1- and 5-year survival. RESULTS: In 2006-2011, the overall standardized ALD incidence decreased from 343 to 311 per 1,000,000 population per year. ALD incidence increased among women aged 65 years or older, but decreased in younger persons and men. Persons born in 1950-1959 had higher age-specific incidence than earlier and later birth cohorts. The prevalence (0.2% of the Danish adult population) and hospitalization rate were constant. The 1- and 5-year survival were 43 and 70%, respectively. CONCLUSION: In Denmark, persons born in 1950-1959 have had the highest age-specific incidence. The overall ALD incidence has been decreasing (along with per capita consumption). Despite increases in affordability during the study period, Denmark did not experience the increase in ALD seen, for example, in the UK. It is possible that this is due to the greater impact of government recommendations on safer drinking in Denmark than the UK. SN - 1464-3502 UR - https://www.unboundmedicine.com/medline/citation/25681463/Epidemiology_of_alcoholic_liver_disease_in_Denmark_2006_2011:_a_population_based_study_ DB - PRIME DP - Unbound Medicine ER -