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MIND diet associated with reduced incidence of Alzheimer's disease.
Alzheimers Dement. 2015 Sep; 11(9):1007-14.AD

Abstract

INTRODUCTION

In a previous study, higher concordance to the MIND diet, a hybrid Mediterranean-Dietary Approaches to Stop Hypertension diet, was associated with slower cognitive decline. In this study we related these three dietary patterns to incident Alzheimer's disease (AD).

METHODS

We investigated the diet-AD relations in a prospective study of 923 participants, ages 58 to 98 years, followed on average 4.5 years. Diet was assessed by a semiquantitative food frequency questionnaire.

RESULTS

In adjusted proportional hazards models, the second (hazards ratio or HR = 0.65, 95% confidence interval or CI 0.44, 0.98) and highest tertiles (HR = 0.47, 95% CI 0.26, 0.76) of MIND diet scores had lower rates of AD versus tertile 1, whereas only the third tertiles of the DASH (HR = 0.61, 95% CI 0.38, 0.97) and Mediterranean (HR = 0.46, 95% CI 0.26, 0.79) diets were associated with lower AD rates.

DISCUSSION

High adherence to all three diets may reduce AD risk. Moderate adherence to the MIND diet may also decrease AD risk.

Authors+Show Affiliations

Department of Internal Medicine and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA. Electronic address: martha_c_morris@rush.edu.Department of Clinical Nutrition and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.Department of Internal Medicine and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.Department of Behavioral Sciences and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA; Department of Neurology and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.Department of Behavioral Sciences and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA; Department of Neurology and the Rush Alzheimer's Disease Center at Rush University Medical Center, Chicago, IL, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

25681666

Citation

Morris, Martha Clare, et al. "MIND Diet Associated With Reduced Incidence of Alzheimer's Disease." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 11, no. 9, 2015, pp. 1007-14.
Morris MC, Tangney CC, Wang Y, et al. MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimers Dement. 2015;11(9):1007-14.
Morris, M. C., Tangney, C. C., Wang, Y., Sacks, F. M., Bennett, D. A., & Aggarwal, N. T. (2015). MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 11(9), 1007-14. https://doi.org/10.1016/j.jalz.2014.11.009
Morris MC, et al. MIND Diet Associated With Reduced Incidence of Alzheimer's Disease. Alzheimers Dement. 2015;11(9):1007-14. PubMed PMID: 25681666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MIND diet associated with reduced incidence of Alzheimer's disease. AU - Morris,Martha Clare, AU - Tangney,Christy C, AU - Wang,Yamin, AU - Sacks,Frank M, AU - Bennett,David A, AU - Aggarwal,Neelum T, Y1 - 2015/02/11/ PY - 2014/08/16/received PY - 2014/10/29/revised PY - 2014/11/21/accepted PY - 2015/2/15/entrez PY - 2015/2/15/pubmed PY - 2016/6/22/medline KW - Aging KW - Alzheimer's disease KW - Cognition KW - Epidemiological study KW - Nutrition KW - diet SP - 1007 EP - 14 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 11 IS - 9 N2 - INTRODUCTION: In a previous study, higher concordance to the MIND diet, a hybrid Mediterranean-Dietary Approaches to Stop Hypertension diet, was associated with slower cognitive decline. In this study we related these three dietary patterns to incident Alzheimer's disease (AD). METHODS: We investigated the diet-AD relations in a prospective study of 923 participants, ages 58 to 98 years, followed on average 4.5 years. Diet was assessed by a semiquantitative food frequency questionnaire. RESULTS: In adjusted proportional hazards models, the second (hazards ratio or HR = 0.65, 95% confidence interval or CI 0.44, 0.98) and highest tertiles (HR = 0.47, 95% CI 0.26, 0.76) of MIND diet scores had lower rates of AD versus tertile 1, whereas only the third tertiles of the DASH (HR = 0.61, 95% CI 0.38, 0.97) and Mediterranean (HR = 0.46, 95% CI 0.26, 0.79) diets were associated with lower AD rates. DISCUSSION: High adherence to all three diets may reduce AD risk. Moderate adherence to the MIND diet may also decrease AD risk. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/25681666/MIND_diet_associated_with_reduced_incidence_of_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(15)00017-5 DB - PRIME DP - Unbound Medicine ER -