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Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans.
Pediatr Pulmonol 2015; 50(5):E13-6PP

Abstract

Postinfectious bronchiolitis obliterans is a chronic incapacitating disease with persistent airway inflammation. However, the efficacy of systemic corticosteroids has never been studied systematically. In the presented case, serial spirometry, plethysmography measurements, and nocturnal oximetry demonstrated progressive decline in lung hyperinflation and air-trapping and improvement in expiratory function and nocturnal oxygenation during and after six three-day courses of high-dose methylprednisolone (30 mg/kg/day). At four months post treatment, most gain in lung function was lost suggesting the need for sustained immunosuppression. Randomized, controlled trials using serial plethysmography measurements, spirometry, and nocturnal oximetry could provide evidence for the management of postinfectious bronchiolitis obliterans.

Authors+Show Affiliations

Pediatric Pulmonology Unit, First Department of Pediatrics, University of Athens School of Medicine and Aghia Sophia Children's Hospital, Athens, Greece.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25682945

Citation

Tanou, Kalliopi, et al. "Efficacy of Pulse Methylprednisolone in a Pediatric Case of Postinfectious Bronchiolitis Obliterans." Pediatric Pulmonology, vol. 50, no. 5, 2015, pp. E13-6.
Tanou K, Xaidara A, Kaditis AG. Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans. Pediatr Pulmonol. 2015;50(5):E13-6.
Tanou, K., Xaidara, A., & Kaditis, A. G. (2015). Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans. Pediatric Pulmonology, 50(5), pp. E13-6. doi:10.1002/ppul.23157.
Tanou K, Xaidara A, Kaditis AG. Efficacy of Pulse Methylprednisolone in a Pediatric Case of Postinfectious Bronchiolitis Obliterans. Pediatr Pulmonol. 2015;50(5):E13-6. PubMed PMID: 25682945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans. AU - Tanou,Kalliopi, AU - Xaidara,Athina, AU - Kaditis,Athanasios G, Y1 - 2015/02/13/ PY - 2014/10/29/received PY - 2014/12/26/accepted PY - 2015/2/17/entrez PY - 2015/2/17/pubmed PY - 2016/4/8/medline KW - bronchiolitis obliterans KW - nocturnal hypoxemia KW - pulse methylprednisolone SP - E13 EP - 6 JF - Pediatric pulmonology JO - Pediatr. Pulmonol. VL - 50 IS - 5 N2 - Postinfectious bronchiolitis obliterans is a chronic incapacitating disease with persistent airway inflammation. However, the efficacy of systemic corticosteroids has never been studied systematically. In the presented case, serial spirometry, plethysmography measurements, and nocturnal oximetry demonstrated progressive decline in lung hyperinflation and air-trapping and improvement in expiratory function and nocturnal oxygenation during and after six three-day courses of high-dose methylprednisolone (30 mg/kg/day). At four months post treatment, most gain in lung function was lost suggesting the need for sustained immunosuppression. Randomized, controlled trials using serial plethysmography measurements, spirometry, and nocturnal oximetry could provide evidence for the management of postinfectious bronchiolitis obliterans. SN - 1099-0496 UR - https://www.unboundmedicine.com/medline/citation/25682945/Efficacy_of_pulse_methylprednisolone_in_a_pediatric_case_of_postinfectious_bronchiolitis_obliterans_ L2 - https://doi.org/10.1002/ppul.23157 DB - PRIME DP - Unbound Medicine ER -