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Kinetics features changes before and after intra-articular hyaluronic acid injections in patients with knee osteoarthritis.
Clin Neurol Neurosurg. 2015 Feb; 129 Suppl 1:S21-6.CN

Abstract

OBJECTIVES

To examine the kinetic features in patients with knee osteoarthritis (OA) after intra-articular hyaluronic acid (IAHA) injections in different time periods.

DESIGN

A single group repeated measures study.

SETTING

Gait laboratory in a tertiary hospital.

PARTICIPANTS

Twenty-five subjects with bilateral symptomatic knee OA and 15 healthy control subjects.

INTERVENTION

Gait analyses were performed in both control and OA groups before (baseline), and after the completion of IAHA injections (1 week, 3 months, and 6 months).

MAIN OUTCOME MEASURES

Knee pain and functional indices were assessed using a visual analogue scale (VAS) and the Lequesne function Index (LI). Joint kinetic changes were analyzed in the frontal and sagittal planes with 6-camera motion analysis system and two AMTI force plates.

RESULTS

VAS and LI scores were both improved in OA group after IAHA injections (p<0.001). In the frontal plane, increased knee adduction moment (p<0.001) after IAHA treatment was observed and would last up to a period of 6 months. In the sagittal plane, lower knee extension moments at early stance, and larger knee flexion moments at terminal stance were demonstrated after the completion of IAHA injections (p<0.05).

CONCLUSIONS

This study revealed that IAHA injections can provide significant pain relief and improvement in activity of daily living function for patients with knee OA. However, the reduction in pain and the increase in knee adduction moment may last up to 6 months. This may cause excessive loading on the knee joints, which may further accelerate the rate of knee degeneration. As a result, longer study time is needed to determine whether the observed kinetic findings in this study are associated with detrimental outcomes on the knee joints.

Authors+Show Affiliations

Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, Taiwan.Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Linkou, Taiwan; School of Medicine, Chang Gung University, Taiwan.School of Sports Medicine, China Medical University, Taichung, Taiwan. Electronic address: whhong@mail.cmu.edu.tw.Department of Industrial Engineering and Management, Taipei University of Technology, Taipei, Taiwan.

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

25683308

Citation

Tang, Alice Chu-Wen, et al. "Kinetics Features Changes Before and After Intra-articular Hyaluronic Acid Injections in Patients With Knee Osteoarthritis." Clinical Neurology and Neurosurgery, vol. 129 Suppl 1, 2015, pp. S21-6.
Tang AC, Tang SF, Hong WH, et al. Kinetics features changes before and after intra-articular hyaluronic acid injections in patients with knee osteoarthritis. Clin Neurol Neurosurg. 2015;129 Suppl 1:S21-6.
Tang, A. C., Tang, S. F., Hong, W. H., & Chen, H. C. (2015). Kinetics features changes before and after intra-articular hyaluronic acid injections in patients with knee osteoarthritis. Clinical Neurology and Neurosurgery, 129 Suppl 1, S21-6. https://doi.org/10.1016/S0303-8467(15)30007-X
Tang AC, et al. Kinetics Features Changes Before and After Intra-articular Hyaluronic Acid Injections in Patients With Knee Osteoarthritis. Clin Neurol Neurosurg. 2015;129 Suppl 1:S21-6. PubMed PMID: 25683308.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Kinetics features changes before and after intra-articular hyaluronic acid injections in patients with knee osteoarthritis. AU - Tang,Alice Chu-Wen, AU - Tang,Simon Fuk-Tan, AU - Hong,Wei-Hsien, AU - Chen,Hsieh-Ching, PY - 2015/2/17/entrez PY - 2015/2/17/pubmed PY - 2015/11/13/medline KW - Gait KW - Hyaluronic acid KW - Intra-articular injection KW - Kinetic KW - Knee osteoarthritis SP - S21 EP - 6 JF - Clinical neurology and neurosurgery JO - Clin Neurol Neurosurg VL - 129 Suppl 1 N2 - OBJECTIVES: To examine the kinetic features in patients with knee osteoarthritis (OA) after intra-articular hyaluronic acid (IAHA) injections in different time periods. DESIGN: A single group repeated measures study. SETTING: Gait laboratory in a tertiary hospital. PARTICIPANTS: Twenty-five subjects with bilateral symptomatic knee OA and 15 healthy control subjects. INTERVENTION: Gait analyses were performed in both control and OA groups before (baseline), and after the completion of IAHA injections (1 week, 3 months, and 6 months). MAIN OUTCOME MEASURES: Knee pain and functional indices were assessed using a visual analogue scale (VAS) and the Lequesne function Index (LI). Joint kinetic changes were analyzed in the frontal and sagittal planes with 6-camera motion analysis system and two AMTI force plates. RESULTS: VAS and LI scores were both improved in OA group after IAHA injections (p<0.001). In the frontal plane, increased knee adduction moment (p<0.001) after IAHA treatment was observed and would last up to a period of 6 months. In the sagittal plane, lower knee extension moments at early stance, and larger knee flexion moments at terminal stance were demonstrated after the completion of IAHA injections (p<0.05). CONCLUSIONS: This study revealed that IAHA injections can provide significant pain relief and improvement in activity of daily living function for patients with knee OA. However, the reduction in pain and the increase in knee adduction moment may last up to 6 months. This may cause excessive loading on the knee joints, which may further accelerate the rate of knee degeneration. As a result, longer study time is needed to determine whether the observed kinetic findings in this study are associated with detrimental outcomes on the knee joints. SN - 1872-6968 UR - https://www.unboundmedicine.com/medline/citation/25683308/Kinetics_features_changes_before_and_after_intra_articular_hyaluronic_acid_injections_in_patients_with_knee_osteoarthritis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-8467(15)30007-X DB - PRIME DP - Unbound Medicine ER -