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Incorporation of poly(ethylene glycol) grafted cellulose nanocrystals in poly(lactic acid) electrospun nanocomposite fibers as potential scaffolds for bone tissue engineering.
Mater Sci Eng C Mater Biol Appl. 2015 Apr; 49:463-471.MS

Abstract

Poly(ethylene glycol) (PEG)-grafted cellulose nanocrystals (CNCs) were successfully synthesized and incorporated into poly(lactic acid) (PLA) as a reinforcing filler to produce nanocomposite scaffolds consisting of CNC-g-PEG and PLA using an electrospinning technique. Morphological, thermal, mechanical, and wettability properties as well as preliminary biocompatibility using human mesenchymal stem cells (hMSCs) of PLA/CNC and PLA/CNC-g-PEG nanocomposite scaffolds were characterized and compared. The average diameter of the electrospun nanofibers decreased with increased filler loading level, due to the increased conductivity of the electrospun solutions. DSC results showed that both the glass transition temperature and cold crystallization temperature decreased progressively with higher CNC-g-PEG loading level, suggesting that improved interfacial adhesion between CNCs and PLA was achieved by grafting PEG onto the CNCs. Wettability of the electrospun nanofibers was not affected with the addition of CNCs or CNC-g-PEG and indicating that the fillers tended to stay inside of the fiber matrix under electrical field. The tensile strength of the composite fiber mats was effectively improved by the addition of up to 5% CNC-g-PEG up to 5wt.%. In addition, the cell culture results showed that PLA/CNC-g-PEG composite nanofibers exhibited improved biocompatibility to hMSCs, which revealed the potential application of this nanocomposite as the scaffolds in bone tissue engineering.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zhang C
State Key Laboratory of Polymer Materials Engineering of China, Polymer Research Institute of Sichuan University, Chengdu 610065, China; Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Chemistry and Materials Engineering, Guiyang University, guiyang 550005, China.
Salick MR
Department of Engineering Physics, University of Wisconsin-Madison, Madison, WI 53706, USA.
Cordie TM
Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.
Ellingham T
Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA.
Dan Y
State Key Laboratory of Polymer Materials Engineering of China, Polymer Research Institute of Sichuan University, Chengdu 610065, China. Electronic address: danyi@scu.edu.cn.
Turng LS
Department of Mechanical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: turng@engr.wisc.edu.

MeSH

Biocompatible MaterialsBone and BonesCelluloseNanocompositesNanoparticlesPolyethylene GlycolsTissue EngineeringTissue Scaffolds

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

25686973

Citation

Zhang, Chunmei, et al. "Incorporation of Poly(ethylene Glycol) Grafted Cellulose Nanocrystals in Poly(lactic Acid) Electrospun Nanocomposite Fibers as Potential Scaffolds for Bone Tissue Engineering." Materials Science & Engineering. C, Materials for Biological Applications, vol. 49, 2015, pp. 463-471.
Zhang C, Salick MR, Cordie TM, et al. Incorporation of poly(ethylene glycol) grafted cellulose nanocrystals in poly(lactic acid) electrospun nanocomposite fibers as potential scaffolds for bone tissue engineering. Mater Sci Eng C Mater Biol Appl. 2015;49:463-471.
Zhang, C., Salick, M. R., Cordie, T. M., Ellingham, T., Dan, Y., & Turng, L. S. (2015). Incorporation of poly(ethylene glycol) grafted cellulose nanocrystals in poly(lactic acid) electrospun nanocomposite fibers as potential scaffolds for bone tissue engineering. Materials Science & Engineering. C, Materials for Biological Applications, 49, 463-471. https://doi.org/10.1016/j.msec.2015.01.024
Zhang C, et al. Incorporation of Poly(ethylene Glycol) Grafted Cellulose Nanocrystals in Poly(lactic Acid) Electrospun Nanocomposite Fibers as Potential Scaffolds for Bone Tissue Engineering. Mater Sci Eng C Mater Biol Appl. 2015;49:463-471. PubMed PMID: 25686973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incorporation of poly(ethylene glycol) grafted cellulose nanocrystals in poly(lactic acid) electrospun nanocomposite fibers as potential scaffolds for bone tissue engineering. AU - Zhang,Chunmei, AU - Salick,Max R, AU - Cordie,Travis M, AU - Ellingham,Tom, AU - Dan,Yi, AU - Turng,Lih-Sheng, Y1 - 2015/01/08/ PY - 2014/09/22/received PY - 2014/11/09/revised PY - 2015/01/06/accepted PY - 2015/2/18/entrez PY - 2015/2/18/pubmed PY - 2016/4/6/medline KW - Cellulose nanocrystals KW - Interfacial adhesion KW - Mechanical properties KW - Poly(ethylene glycol) KW - Poly(lactic acid) SP - 463 EP - 471 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 49 N2 - Poly(ethylene glycol) (PEG)-grafted cellulose nanocrystals (CNCs) were successfully synthesized and incorporated into poly(lactic acid) (PLA) as a reinforcing filler to produce nanocomposite scaffolds consisting of CNC-g-PEG and PLA using an electrospinning technique. Morphological, thermal, mechanical, and wettability properties as well as preliminary biocompatibility using human mesenchymal stem cells (hMSCs) of PLA/CNC and PLA/CNC-g-PEG nanocomposite scaffolds were characterized and compared. The average diameter of the electrospun nanofibers decreased with increased filler loading level, due to the increased conductivity of the electrospun solutions. DSC results showed that both the glass transition temperature and cold crystallization temperature decreased progressively with higher CNC-g-PEG loading level, suggesting that improved interfacial adhesion between CNCs and PLA was achieved by grafting PEG onto the CNCs. Wettability of the electrospun nanofibers was not affected with the addition of CNCs or CNC-g-PEG and indicating that the fillers tended to stay inside of the fiber matrix under electrical field. The tensile strength of the composite fiber mats was effectively improved by the addition of up to 5% CNC-g-PEG up to 5wt.%. In addition, the cell culture results showed that PLA/CNC-g-PEG composite nanofibers exhibited improved biocompatibility to hMSCs, which revealed the potential application of this nanocomposite as the scaffolds in bone tissue engineering. SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/25686973/Incorporation_of_poly_ethylene_glycol__grafted_cellulose_nanocrystals_in_poly_lactic_acid__electrospun_nanocomposite_fibers_as_potential_scaffolds_for_bone_tissue_engineering_ DB - PRIME DP - Unbound Medicine ER -