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The emerging role of tissue plasminogen activator in the management of severe frostbite.
J Burn Care Res. 2015 Mar-Apr; 36(2):e62-6.JB

Abstract

This article presents a small case series demonstrating clinical success with thrombolytic agents for severe frostbite injury to the lower extremities. The authors report three patients with severe frostbite injuries to their distal lower extremities who were managed with urgent interventional radiology and intra-arterial tissue plasminogen activator infusion according to a prespecified protocol. Limbs and digits were successfully salvaged and patients returned to normal activity within 2 weeks. Although further studies are needed, results of this study support a new approach in the management of frostbite: from conservative management and observation to urgent interventional radiology and possible tissue plasminogen activator infusion. A protocol for the management of such injuries is presented.

Authors+Show Affiliations

From the *Division of Burns, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston; †Department of Plastic and Reconstructive Surgery, Johns Hopkins University, Baltimore, Maryland; ‡UNECOM/Kent Hospital Emergency Medicine Program, Warwick, Rhode Island; and §Department of Radiology, Massachusetts General Hospital, Boston.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25687362

Citation

Ibrahim, Amir E., et al. "The Emerging Role of Tissue Plasminogen Activator in the Management of Severe Frostbite." Journal of Burn Care & Research : Official Publication of the American Burn Association, vol. 36, no. 2, 2015, pp. e62-6.
Ibrahim AE, Goverman J, Sarhane KA, et al. The emerging role of tissue plasminogen activator in the management of severe frostbite. J Burn Care Res. 2015;36(2):e62-6.
Ibrahim, A. E., Goverman, J., Sarhane, K. A., Donofrio, J., Walker, T. G., & Fagan, S. P. (2015). The emerging role of tissue plasminogen activator in the management of severe frostbite. Journal of Burn Care & Research : Official Publication of the American Burn Association, 36(2), e62-6. https://doi.org/10.1097/BCR.0000000000000135
Ibrahim AE, et al. The Emerging Role of Tissue Plasminogen Activator in the Management of Severe Frostbite. J Burn Care Res. 2015 Mar-Apr;36(2):e62-6. PubMed PMID: 25687362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The emerging role of tissue plasminogen activator in the management of severe frostbite. AU - Ibrahim,Amir E, AU - Goverman,Jeremy, AU - Sarhane,Karim A, AU - Donofrio,Jill, AU - Walker,T Gregory, AU - Fagan,Shawn P, PY - 2015/2/18/entrez PY - 2015/2/18/pubmed PY - 2015/12/15/medline SP - e62 EP - 6 JF - Journal of burn care & research : official publication of the American Burn Association JO - J Burn Care Res VL - 36 IS - 2 N2 - This article presents a small case series demonstrating clinical success with thrombolytic agents for severe frostbite injury to the lower extremities. The authors report three patients with severe frostbite injuries to their distal lower extremities who were managed with urgent interventional radiology and intra-arterial tissue plasminogen activator infusion according to a prespecified protocol. Limbs and digits were successfully salvaged and patients returned to normal activity within 2 weeks. Although further studies are needed, results of this study support a new approach in the management of frostbite: from conservative management and observation to urgent interventional radiology and possible tissue plasminogen activator infusion. A protocol for the management of such injuries is presented. SN - 1559-0488 UR - https://www.unboundmedicine.com/medline/citation/25687362/The_emerging_role_of_tissue_plasminogen_activator_in_the_management_of_severe_frostbite_ L2 - https://academic.oup.com/jbcr/article-lookup/doi/10.1097/BCR.0000000000000135 DB - PRIME DP - Unbound Medicine ER -