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Procalcitonin as an Early Predictor of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndromes Who Underwent Percutaneous Coronary Intervention.
Angiology. 2015 Nov; 66(10):957-63.A

Abstract

Contrast-induced acute kidney injury (CI-AKI) is a major issue after percutaneous coronary intervention (PCI), especially in the setting of acute coronary syndrome (ACS). Contrast-induced acute kidney injury is associated with increased mortality and morbidity. Inflammation plays an important role in the pathophysiology of CI-AKI. Procalcitonin (PCT) is introduced as a new marker of inflammation. We sought to examine whether admission PCT levels predict the development of CI-AKI. Patients (n = 814) were divided into 2 groups, namely, CI-AKI (-) and CI-AKI (+). An increase in serum creatinine of ≥0.5 mg/dL from baseline within 48 to 72 hours of contrast exposure was defined as CI-AKI. Contrast-induced acute kidney injury occurred in 96 (11.8%) patients. The PCT levels were significantly higher in patients with CI-AKI than in those without, 0.11 (0.056-0.495) vs 0.04 (0.02-0.078) µg/L; P < .001. After multivariable analysis, PCT remained a significant independent predictor of CI-AKI (odds ratio 2.544; 95% CI [1.207-5.347]; P = .014) as well as age, women, white blood cell, hemoglobin, glomerular filtration rate, creatine kinase myocarial band, and SYNTAX score. In conclusion, serum PCT levels are independently associated with a risk of CI-AKI in patients with ACS who underwent urgent PCI.

Authors+Show Affiliations

Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey alpkurtul@yahoo.com.Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.Department of Cardiology, Ankara Education and Research Hospital, Ankara, Turkey.Department of Cardiology, Ankara University Faculty of Medicine, Ankara, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

25688117

Citation

Kurtul, Alparslan, et al. "Procalcitonin as an Early Predictor of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndromes Who Underwent Percutaneous Coronary Intervention." Angiology, vol. 66, no. 10, 2015, pp. 957-63.
Kurtul A, Murat SN, Yarlioglues M, et al. Procalcitonin as an Early Predictor of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndromes Who Underwent Percutaneous Coronary Intervention. Angiology. 2015;66(10):957-63.
Kurtul, A., Murat, S. N., Yarlioglues, M., Duran, M., Ocek, A. H., Celik, I. E., Kilic, A., Koseoglu, C., Oksuz, F., & Baris, V. O. (2015). Procalcitonin as an Early Predictor of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndromes Who Underwent Percutaneous Coronary Intervention. Angiology, 66(10), 957-63. https://doi.org/10.1177/0003319715572218
Kurtul A, et al. Procalcitonin as an Early Predictor of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndromes Who Underwent Percutaneous Coronary Intervention. Angiology. 2015;66(10):957-63. PubMed PMID: 25688117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Procalcitonin as an Early Predictor of Contrast-Induced Acute Kidney Injury in Patients With Acute Coronary Syndromes Who Underwent Percutaneous Coronary Intervention. AU - Kurtul,Alparslan, AU - Murat,Sani Namik, AU - Yarlioglues,Mikail, AU - Duran,Mustafa, AU - Ocek,Adil Hakan, AU - Celik,Ibrahim Etem, AU - Kilic,Alparslan, AU - Koseoglu,Cemal, AU - Oksuz,Fatih, AU - Baris,Veysel Ozgur, Y1 - 2015/02/16/ PY - 2015/2/18/entrez PY - 2015/2/18/pubmed PY - 2016/1/12/medline KW - acute coronary syndrome KW - contrast-induced acute kidney injury KW - percutaneous coronary intervention KW - procalcitonin SP - 957 EP - 63 JF - Angiology JO - Angiology VL - 66 IS - 10 N2 - Contrast-induced acute kidney injury (CI-AKI) is a major issue after percutaneous coronary intervention (PCI), especially in the setting of acute coronary syndrome (ACS). Contrast-induced acute kidney injury is associated with increased mortality and morbidity. Inflammation plays an important role in the pathophysiology of CI-AKI. Procalcitonin (PCT) is introduced as a new marker of inflammation. We sought to examine whether admission PCT levels predict the development of CI-AKI. Patients (n = 814) were divided into 2 groups, namely, CI-AKI (-) and CI-AKI (+). An increase in serum creatinine of ≥0.5 mg/dL from baseline within 48 to 72 hours of contrast exposure was defined as CI-AKI. Contrast-induced acute kidney injury occurred in 96 (11.8%) patients. The PCT levels were significantly higher in patients with CI-AKI than in those without, 0.11 (0.056-0.495) vs 0.04 (0.02-0.078) µg/L; P < .001. After multivariable analysis, PCT remained a significant independent predictor of CI-AKI (odds ratio 2.544; 95% CI [1.207-5.347]; P = .014) as well as age, women, white blood cell, hemoglobin, glomerular filtration rate, creatine kinase myocarial band, and SYNTAX score. In conclusion, serum PCT levels are independently associated with a risk of CI-AKI in patients with ACS who underwent urgent PCI. SN - 1940-1574 UR - https://www.unboundmedicine.com/medline/citation/25688117/Procalcitonin_as_an_Early_Predictor_of_Contrast_Induced_Acute_Kidney_Injury_in_Patients_With_Acute_Coronary_Syndromes_Who_Underwent_Percutaneous_Coronary_Intervention_ L2 - http://journals.sagepub.com/doi/full/10.1177/0003319715572218?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -