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Calciphylaxis in catastrophic antiphospholipid antibody syndrome.
Blood Coagul Fibrinolysis 2015; 26(4):467-8BC

Abstract

Antiphospholipid antibody syndrome (APS) is a multisystem disorder characterized by vascular thrombosis and presence of circulating autoantibodies. The presence of APS can predispose to macrovascular as well as microvascular thrombotic events. Renal involvement is a common occurrence especially in the background of systemic lupus erythematosus. Skin appears to be another frequent target organ and a significant proportion of patients may present with skin lesions at the time of diagnosis. We present the case of a patient who presented with skin necrosis secondary to antiphospholipid antibody syndrome despite being on therapeutic anticoagulation and then developed dystrophic calcification secondary to her renal insufficiency. This complex skin condition eventually leads to her demise, as she was not a candidate for surgical management of these lesions. Why is this important? This case brings to our attention the need to consider calciphylaxis as a cause of ecchymotic-appearing skin lesions in dialysis patients on warfarin in patients with antiphospholipid antibody syndrome.

Authors+Show Affiliations

aDepartment of Medicine, Division of Hematology-Oncology and Transplantation bDepartment of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

25688465

Citation

Shah, Surbhi, et al. "Calciphylaxis in Catastrophic Antiphospholipid Antibody Syndrome." Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 26, no. 4, 2015, pp. 467-8.
Shah S, Larson A, Datta Y. Calciphylaxis in catastrophic antiphospholipid antibody syndrome. Blood Coagul Fibrinolysis. 2015;26(4):467-8.
Shah, S., Larson, A., & Datta, Y. (2015). Calciphylaxis in catastrophic antiphospholipid antibody syndrome. Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, 26(4), pp. 467-8. doi:10.1097/MBC.0000000000000253.
Shah S, Larson A, Datta Y. Calciphylaxis in Catastrophic Antiphospholipid Antibody Syndrome. Blood Coagul Fibrinolysis. 2015;26(4):467-8. PubMed PMID: 25688465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calciphylaxis in catastrophic antiphospholipid antibody syndrome. AU - Shah,Surbhi, AU - Larson,Andrew, AU - Datta,Yvonne, PY - 2015/2/18/entrez PY - 2015/2/18/pubmed PY - 2016/1/26/medline SP - 467 EP - 8 JF - Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis JO - Blood Coagul. Fibrinolysis VL - 26 IS - 4 N2 - Antiphospholipid antibody syndrome (APS) is a multisystem disorder characterized by vascular thrombosis and presence of circulating autoantibodies. The presence of APS can predispose to macrovascular as well as microvascular thrombotic events. Renal involvement is a common occurrence especially in the background of systemic lupus erythematosus. Skin appears to be another frequent target organ and a significant proportion of patients may present with skin lesions at the time of diagnosis. We present the case of a patient who presented with skin necrosis secondary to antiphospholipid antibody syndrome despite being on therapeutic anticoagulation and then developed dystrophic calcification secondary to her renal insufficiency. This complex skin condition eventually leads to her demise, as she was not a candidate for surgical management of these lesions. Why is this important? This case brings to our attention the need to consider calciphylaxis as a cause of ecchymotic-appearing skin lesions in dialysis patients on warfarin in patients with antiphospholipid antibody syndrome. SN - 1473-5733 UR - https://www.unboundmedicine.com/medline/citation/25688465/Calciphylaxis_in_catastrophic_antiphospholipid_antibody_syndrome_ L2 - http://dx.doi.org/10.1097/MBC.0000000000000253 DB - PRIME DP - Unbound Medicine ER -