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The effect of an increase in inhaled allergen dose after terfenadine on the occurrence and magnitude of the late asthmatic response.
Clin Exp Allergy 1989; 19(2):209-16CE

Abstract

We have attempted to use a potent and selective histamine H1-receptor antagonist terfenadine to allow a larger dose of allergen to be administered to previous single early responders to investigate if an increased dose of allergen could induce a late asthmatic response. Pre-treatment with 180 mg of terfenadine enabled a geometric mean increase in allergen dose of 4.12-fold to be inhaled by eight atopic subjects with mild asthma, who initially were classified as single early responders, with maximal fall in FEV1 3-8 hr after allergen challenge (Lmax) of less than 15% from baseline value. The magnitude of early asthmatic response was similar to that obtained on the control day when allergen challenge was performed in the absence of terfenadine. Two subjects were converted to dual responders with Lmax of 23.1 and 24.3%, which occurred with a 32- and 65-fold increase in allergen dose respectively, and a 6- and 4.9-fold decrease in non-specific airways responsiveness measured as the cumulative provocative concentration of methacholine that caused a 20% fall in FEV1 from baseline. The remaining six subjects failed to achieve an Lmax of greater than 10% even with a 1.29-2.66-fold increase in allergen dose. For the group as a whole an increase in allergen dose was associated with an increase in overall bronchoconstrictor response 3-8 hr after challenge. These results indicate that it is possible to induce a late asthmatic response in a subject who previously demonstrated only an early response by increasing the dose of allergen inhaled.

Authors+Show Affiliations

Immunopharmacology Group, Medicine 1, Southampton General Hospital.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2568881

Citation

Lai, C K., et al. "The Effect of an Increase in Inhaled Allergen Dose After Terfenadine On the Occurrence and Magnitude of the Late Asthmatic Response." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 19, no. 2, 1989, pp. 209-16.
Lai CK, Beasley R, Holgate ST. The effect of an increase in inhaled allergen dose after terfenadine on the occurrence and magnitude of the late asthmatic response. Clin Exp Allergy. 1989;19(2):209-16.
Lai, C. K., Beasley, R., & Holgate, S. T. (1989). The effect of an increase in inhaled allergen dose after terfenadine on the occurrence and magnitude of the late asthmatic response. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 19(2), pp. 209-16.
Lai CK, Beasley R, Holgate ST. The Effect of an Increase in Inhaled Allergen Dose After Terfenadine On the Occurrence and Magnitude of the Late Asthmatic Response. Clin Exp Allergy. 1989;19(2):209-16. PubMed PMID: 2568881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of an increase in inhaled allergen dose after terfenadine on the occurrence and magnitude of the late asthmatic response. AU - Lai,C K, AU - Beasley,R, AU - Holgate,S T, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 209 EP - 16 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 19 IS - 2 N2 - We have attempted to use a potent and selective histamine H1-receptor antagonist terfenadine to allow a larger dose of allergen to be administered to previous single early responders to investigate if an increased dose of allergen could induce a late asthmatic response. Pre-treatment with 180 mg of terfenadine enabled a geometric mean increase in allergen dose of 4.12-fold to be inhaled by eight atopic subjects with mild asthma, who initially were classified as single early responders, with maximal fall in FEV1 3-8 hr after allergen challenge (Lmax) of less than 15% from baseline value. The magnitude of early asthmatic response was similar to that obtained on the control day when allergen challenge was performed in the absence of terfenadine. Two subjects were converted to dual responders with Lmax of 23.1 and 24.3%, which occurred with a 32- and 65-fold increase in allergen dose respectively, and a 6- and 4.9-fold decrease in non-specific airways responsiveness measured as the cumulative provocative concentration of methacholine that caused a 20% fall in FEV1 from baseline. The remaining six subjects failed to achieve an Lmax of greater than 10% even with a 1.29-2.66-fold increase in allergen dose. For the group as a whole an increase in allergen dose was associated with an increase in overall bronchoconstrictor response 3-8 hr after challenge. These results indicate that it is possible to induce a late asthmatic response in a subject who previously demonstrated only an early response by increasing the dose of allergen inhaled. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/2568881/The_effect_of_an_increase_in_inhaled_allergen_dose_after_terfenadine_on_the_occurrence_and_magnitude_of_the_late_asthmatic_response_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=1989&volume=19&issue=2&spage=209 DB - PRIME DP - Unbound Medicine ER -