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Plasma near-infrared spectroscopy for diagnosis of idiopathic Parkinson's disease: the SPIN-PD study.
Biomark Med. 2015; 9(2):89-97.BM

Abstract

AIM

There are no established chemical biomarkers of idiopathic Parkinson's disease (PD). The results of a prior metabolomics-based biomarker study suggested that near-infrared spectroscopy of blood plasma samples may distinguish idiopathic PD from neurologically normal controls.

METHODS

Near-infrared spectroscopy was used to detect and quantify substrate modifications in blood plasma samples derived from 71 PD subjects enrolled in the PostCEPT observational study and 68 normal control subjects.

RESULTS

Near-infrared spectra values were significantly higher in the PD group compared with the control group when adjusted for age and gender (PD: adjusted mean 0.49 [95% CI: 0.45-0.53]; control: adjusted mean 0.40 [95% CI: 0.36-0.44]; p = 0.004, multiple regression).

CONCLUSION

Near-infrared spectra of blood plasma in early-stage idiopathic PD differ from those of non-neurological control subjects. However, the degree of overlap between the groups limits the use of this technique in its present form as a PD biomarker for routine clinical practice.

Authors+Show Affiliations

Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25689898

Citation

Ravina, Bernard, et al. "Plasma Near-infrared Spectroscopy for Diagnosis of Idiopathic Parkinson's Disease: the SPIN-PD Study." Biomarkers in Medicine, vol. 9, no. 2, 2015, pp. 89-97.
Ravina B, Eberly S, Oakes D, et al. Plasma near-infrared spectroscopy for diagnosis of idiopathic Parkinson's disease: the SPIN-PD study. Biomark Med. 2015;9(2):89-97.
Ravina, B., Eberly, S., Oakes, D., Lang, A. E., Dodelet, V., Roos, P., Harman, J., Shoulson, I., & Schipper, H. M. (2015). Plasma near-infrared spectroscopy for diagnosis of idiopathic Parkinson's disease: the SPIN-PD study. Biomarkers in Medicine, 9(2), 89-97. https://doi.org/10.2217/bmm.14.103
Ravina B, et al. Plasma Near-infrared Spectroscopy for Diagnosis of Idiopathic Parkinson's Disease: the SPIN-PD Study. Biomark Med. 2015;9(2):89-97. PubMed PMID: 25689898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma near-infrared spectroscopy for diagnosis of idiopathic Parkinson's disease: the SPIN-PD study. AU - Ravina,Bernard, AU - Eberly,Shirley, AU - Oakes,David, AU - Lang,Anthony E, AU - Dodelet,Vince, AU - Roos,Pieter, AU - Harman,Jennifer, AU - Shoulson,Ira, AU - Schipper,Hyman M, PY - 2015/2/19/entrez PY - 2015/2/19/pubmed PY - 2015/12/15/medline KW - Parkinson's disease KW - biomarker KW - diagnosis KW - near-infrared spectroscopy KW - oxidative stress KW - plasma SP - 89 EP - 97 JF - Biomarkers in medicine JO - Biomark Med VL - 9 IS - 2 N2 - AIM: There are no established chemical biomarkers of idiopathic Parkinson's disease (PD). The results of a prior metabolomics-based biomarker study suggested that near-infrared spectroscopy of blood plasma samples may distinguish idiopathic PD from neurologically normal controls. METHODS: Near-infrared spectroscopy was used to detect and quantify substrate modifications in blood plasma samples derived from 71 PD subjects enrolled in the PostCEPT observational study and 68 normal control subjects. RESULTS: Near-infrared spectra values were significantly higher in the PD group compared with the control group when adjusted for age and gender (PD: adjusted mean 0.49 [95% CI: 0.45-0.53]; control: adjusted mean 0.40 [95% CI: 0.36-0.44]; p = 0.004, multiple regression). CONCLUSION: Near-infrared spectra of blood plasma in early-stage idiopathic PD differ from those of non-neurological control subjects. However, the degree of overlap between the groups limits the use of this technique in its present form as a PD biomarker for routine clinical practice. SN - 1752-0371 UR - https://www.unboundmedicine.com/medline/citation/25689898/Plasma_near_infrared_spectroscopy_for_diagnosis_of_idiopathic_Parkinson's_disease:_the_SPIN_PD_study_ L2 - https://www.futuremedicine.com/doi/10.2217/bmm.14.103?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -