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Correlates of electroencephalographic resting states and erythrocyte membrane docosahexaenoic and eicosapentaenoic acid levels in individuals at ultra-high risk of psychosis.
Aust N Z J Psychiatry. 2016 Jan; 50(1):56-63.AN

Abstract

OBJECTIVE

Abnormal levels of polyunsaturated fatty acids (PUFAs) have been reported in individuals suffering from schizophrenia. The main aim of the present study was to investigate the relationship between erythrocyte membrane fatty acid levels and resting-state brain activity occurring in individuals at ultra-high risk (UHR) of psychosis.

METHOD

The association between erythrocyte membrane fatty acids levels and resting-state brain activity and its value in predicting psychosis was examined in 72 UHR individuals.

RESULTS

In the frontal area, the activity in the fast frequency band Beta2 was positively associated with docosahexaenoic acid (DHA) levels (R = 0.321, P = 0.017), and in the fronto-central area, Beta2 activity showed a positive correlation with eicosapentaenoic acid (EPA) levels (R = 0.305, P = 0.009), regardless of psychosis transition status. Conversely, the slow frequency band Theta was significantly negatively associated with EPA levels in the parieto-occipital region (R = -0.251, P = 0.033. Results also showed that Alpha power was negatively correlated with DHA levels in UHR individuals who did not transition to psychosis, while this correlation was not present in individuals who later transitioned.

CONCLUSION

Our results suggest that individuals at UHR for psychosis who have higher basal omega-3 fatty acids levels present with resting EEG features associated with better states of alertness and vigilance. Furthermore, the improvement in the Alpha synchrony observed along with increased DHA levels in participants who did not transition to psychosis is disturbed in those who did transition. However, these interesting results are limited by the small sample size and low statistical power of the study.

Authors+Show Affiliations

Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia suzie.lavoie@orygen.org.au.School of Psychology, University of New South Wales, Sydney, New South Wales, Australia.Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.Department of Psychiatry, Chonnam National University Medical School, Gwangju, Republic of Korea.Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.Orygen, the National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Australia Centre for Youth Mental Health, The University of Melbourne, Parkville, Victoria, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

25690743

Citation

Lavoie, Suzie, et al. "Correlates of Electroencephalographic Resting States and Erythrocyte Membrane Docosahexaenoic and Eicosapentaenoic Acid Levels in Individuals at Ultra-high Risk of Psychosis." The Australian and New Zealand Journal of Psychiatry, vol. 50, no. 1, 2016, pp. 56-63.
Lavoie S, Whitford TJ, Benninger F, et al. Correlates of electroencephalographic resting states and erythrocyte membrane docosahexaenoic and eicosapentaenoic acid levels in individuals at ultra-high risk of psychosis. Aust N Z J Psychiatry. 2016;50(1):56-63.
Lavoie, S., Whitford, T. J., Benninger, F., Feucht, M., Kim, S. W., Klier, C. M., McNamara, R. K., Rice, S., Schäfer, M. R., & Amminger, G. P. (2016). Correlates of electroencephalographic resting states and erythrocyte membrane docosahexaenoic and eicosapentaenoic acid levels in individuals at ultra-high risk of psychosis. The Australian and New Zealand Journal of Psychiatry, 50(1), 56-63. https://doi.org/10.1177/0004867415571168
Lavoie S, et al. Correlates of Electroencephalographic Resting States and Erythrocyte Membrane Docosahexaenoic and Eicosapentaenoic Acid Levels in Individuals at Ultra-high Risk of Psychosis. Aust N Z J Psychiatry. 2016;50(1):56-63. PubMed PMID: 25690743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlates of electroencephalographic resting states and erythrocyte membrane docosahexaenoic and eicosapentaenoic acid levels in individuals at ultra-high risk of psychosis. AU - Lavoie,Suzie, AU - Whitford,Thomas J, AU - Benninger,Franz, AU - Feucht,Martha, AU - Kim,Sung-Wan, AU - Klier,Claudia M, AU - McNamara,Robert K, AU - Rice,Simon, AU - Schäfer,Miriam R, AU - Amminger,G Paul, Y1 - 2015/02/17/ PY - 2015/2/19/entrez PY - 2015/2/19/pubmed PY - 2016/9/30/medline KW - Docosahexaenoic acid KW - eicosapentaenoic acid KW - omega-3 polyunsaturated fatty acids KW - resting EEG KW - ultra-high risk of psychosis KW - vigilance SP - 56 EP - 63 JF - The Australian and New Zealand journal of psychiatry JO - Aust N Z J Psychiatry VL - 50 IS - 1 N2 - OBJECTIVE: Abnormal levels of polyunsaturated fatty acids (PUFAs) have been reported in individuals suffering from schizophrenia. The main aim of the present study was to investigate the relationship between erythrocyte membrane fatty acid levels and resting-state brain activity occurring in individuals at ultra-high risk (UHR) of psychosis. METHOD: The association between erythrocyte membrane fatty acids levels and resting-state brain activity and its value in predicting psychosis was examined in 72 UHR individuals. RESULTS: In the frontal area, the activity in the fast frequency band Beta2 was positively associated with docosahexaenoic acid (DHA) levels (R = 0.321, P = 0.017), and in the fronto-central area, Beta2 activity showed a positive correlation with eicosapentaenoic acid (EPA) levels (R = 0.305, P = 0.009), regardless of psychosis transition status. Conversely, the slow frequency band Theta was significantly negatively associated with EPA levels in the parieto-occipital region (R = -0.251, P = 0.033. Results also showed that Alpha power was negatively correlated with DHA levels in UHR individuals who did not transition to psychosis, while this correlation was not present in individuals who later transitioned. CONCLUSION: Our results suggest that individuals at UHR for psychosis who have higher basal omega-3 fatty acids levels present with resting EEG features associated with better states of alertness and vigilance. Furthermore, the improvement in the Alpha synchrony observed along with increased DHA levels in participants who did not transition to psychosis is disturbed in those who did transition. However, these interesting results are limited by the small sample size and low statistical power of the study. SN - 1440-1614 UR - https://www.unboundmedicine.com/medline/citation/25690743/Correlates_of_electroencephalographic_resting_states_and_erythrocyte_membrane_docosahexaenoic_and_eicosapentaenoic_acid_levels_in_individuals_at_ultra_high_risk_of_psychosis_ L2 - https://journals.sagepub.com/doi/10.1177/0004867415571168?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -