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Central serous chorioretinopathy fundus autofluorescence comparison with two different confocal scanning laser ophthalmoscopes.
Graefes Arch Clin Exp Ophthalmol 2015; 253(12):2121-7GA

Abstract

PURPOSE

To compare the lesion characteristics of two different types of confocal scanning laser ophthalmoscopy (cSLO) autofluorescence (AF) images in central serous chorioretinopathy (CSC).

METHODS

The study included 63 eyes of 61 patients; 63 pairs of fundus autofluorescence (FAF) images were compared before CSC resolution in 63 eyes, FAF images of 31 eyes were also compared after CSC resolution. The lesion characteristics (brightness and composite pattern) were compared between Heidelberg Retina Angiograph 2 (HRA2; Heidelberg Engineering, Germany) and Optomap Tx (Optomap; Optos, Scotland) FAF images. The lesion composite pattern was categorized as diffuse or granular. Diffuse AF was defined as homogenously increased or decreased AF, and granular AF was defined as dot-like, coarse changes in AF. The mean disease duration and subretinal fluid (SRF) height in the spectral domain optical coherence tomography were compared according to the FAF image characteristics.

RESULTS

Lesion brightness before CSC resolution was hypo-AF in 48 eyes (76.2 %), hyper-AF in three (4.8 %), and mixed-AF in 12 (19.0 %) in HRA2 FAF images. In comparison, nine (14.3 %) images were hypo-AF, 44 (69.8 %) were hyper-AF, and 10 (15.9 %) were mixed-AF in Optomap FAF images (P < 0.0001). There was no significant difference in lesion composite pattern between the two FAF image wavelengths. Patients with lesions that were hyper-AF in Optomap FAF and hypo-AF in HRA2 FAF had a shorter disease duration and greater SRF height (1 month, 281 um) than those who were hyper-AF in both Optomap and HRA2 images (26 months, 153 um; P = 0.004, 0.001).

CONCLUSIONS

The two types of FAF images of CSC showed different lesion brightness before and after CSC resolution but demonstrated similar lesion composite patterns.

Authors+Show Affiliations

Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea.Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea.Department of Ophthalmology, Chung-Ang University College of Medicine, Seoul, Korea.Department of Biostatistics, Korea niversity College of Medicine, Seoul, Korea.Korea University College of Medicine, Seoul, Korea.Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea. ksw64723@korea.ac.kr.Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea.Department of Ophthalmology, Korea University College of Medicine, 516 Gojan-dong, Danwon-gu, Ansan-si, Kyung gi-do, 425-707, Korea.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

25690981

Citation

Nam, Ki Tae, et al. "Central Serous Chorioretinopathy Fundus Autofluorescence Comparison With Two Different Confocal Scanning Laser Ophthalmoscopes." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 253, no. 12, 2015, pp. 2121-7.
Nam KT, Yun CM, Kim JT, et al. Central serous chorioretinopathy fundus autofluorescence comparison with two different confocal scanning laser ophthalmoscopes. Graefes Arch Clin Exp Ophthalmol. 2015;253(12):2121-7.
Nam, K. T., Yun, C. M., Kim, J. T., Yang, K. S., Kim, H. J., Kim, S. W., ... Huh, K. (2015). Central serous chorioretinopathy fundus autofluorescence comparison with two different confocal scanning laser ophthalmoscopes. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 253(12), pp. 2121-7. doi:10.1007/s00417-015-2958-6.
Nam KT, et al. Central Serous Chorioretinopathy Fundus Autofluorescence Comparison With Two Different Confocal Scanning Laser Ophthalmoscopes. Graefes Arch Clin Exp Ophthalmol. 2015;253(12):2121-7. PubMed PMID: 25690981.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central serous chorioretinopathy fundus autofluorescence comparison with two different confocal scanning laser ophthalmoscopes. AU - Nam,Ki Tae, AU - Yun,Cheol Min, AU - Kim,Jee Taek, AU - Yang,Kyung-Sook, AU - Kim,Hyun Joo, AU - Kim,Seong-Woo, AU - Oh,Jaeryung, AU - Huh,Kuhl, Y1 - 2015/02/18/ PY - 2014/11/20/received PY - 2015/01/27/accepted PY - 2014/12/24/revised PY - 2015/2/19/entrez PY - 2015/2/19/pubmed PY - 2016/6/11/medline KW - Central serous chorioretinopathy KW - Confocal scanning laser ophthalmoscopy KW - Fundus autofluorescence KW - Heidelberg Retina Angiograph KW - Optomap SP - 2121 EP - 7 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch. Clin. Exp. Ophthalmol. VL - 253 IS - 12 N2 - PURPOSE: To compare the lesion characteristics of two different types of confocal scanning laser ophthalmoscopy (cSLO) autofluorescence (AF) images in central serous chorioretinopathy (CSC). METHODS: The study included 63 eyes of 61 patients; 63 pairs of fundus autofluorescence (FAF) images were compared before CSC resolution in 63 eyes, FAF images of 31 eyes were also compared after CSC resolution. The lesion characteristics (brightness and composite pattern) were compared between Heidelberg Retina Angiograph 2 (HRA2; Heidelberg Engineering, Germany) and Optomap Tx (Optomap; Optos, Scotland) FAF images. The lesion composite pattern was categorized as diffuse or granular. Diffuse AF was defined as homogenously increased or decreased AF, and granular AF was defined as dot-like, coarse changes in AF. The mean disease duration and subretinal fluid (SRF) height in the spectral domain optical coherence tomography were compared according to the FAF image characteristics. RESULTS: Lesion brightness before CSC resolution was hypo-AF in 48 eyes (76.2 %), hyper-AF in three (4.8 %), and mixed-AF in 12 (19.0 %) in HRA2 FAF images. In comparison, nine (14.3 %) images were hypo-AF, 44 (69.8 %) were hyper-AF, and 10 (15.9 %) were mixed-AF in Optomap FAF images (P < 0.0001). There was no significant difference in lesion composite pattern between the two FAF image wavelengths. Patients with lesions that were hyper-AF in Optomap FAF and hypo-AF in HRA2 FAF had a shorter disease duration and greater SRF height (1 month, 281 um) than those who were hyper-AF in both Optomap and HRA2 images (26 months, 153 um; P = 0.004, 0.001). CONCLUSIONS: The two types of FAF images of CSC showed different lesion brightness before and after CSC resolution but demonstrated similar lesion composite patterns. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/25690981/Central_serous_chorioretinopathy_fundus_autofluorescence_comparison_with_two_different_confocal_scanning_laser_ophthalmoscopes_ L2 - https://dx.doi.org/10.1007/s00417-015-2958-6 DB - PRIME DP - Unbound Medicine ER -