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[Efficacy and safety of sugammadex (Org 25969) in reversing deep neuromuscular block induced by rocuronium or vecuronium in Japanese patients].
Masui. 2014 Oct; 63(10):1083-8.M

Abstract

BACKGROUND

Efficacy and safety of sugammadex in reversing neuromuscular block induced by rocuronium or vecuronium were investgated in Japanese patients.

METHODS

We studied 99 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of rocuronium or vecuronium. During surgery, patients received additional dose of rocuronium or vecuronium for maintenance of deep block. At 1-2 PTC, 0.5-8.0 mg . kg-1 of sugammadex was administered. The neuromuscular block was monitored with acceleromyography using TOF stimuli. Sevoflurane was administered to all treatment groups after intubation.

RESULTS

For the rocuronium-induced neuromuscular block, the mean recovery time of the T4/T1 ratio to 0.9 decreased from 66.9 min in the sugammadex 0.5 mg kg-1 group to 1.3 min in the sugammadex 8.0 mg kg-1 group. For the vecuronium-induced neuromuscular block it decreased from 79.5 min in the sugammadex 0.5 mg . kg-1 group to 2.9 min in the sugammadex 8.0 mg . kg-1 group. No clinical evidence of recurarization or residual curarization was observed.

CONCLUSIONS

The efficacy and safety of sugammadex were confirmed in Japanese surgical patients for reversal from deep block.

Authors

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Pub Type(s)

Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial

Language

jpn

PubMed ID

25693333

Citation

Takeda, Junzo, et al. "[Efficacy and Safety of Sugammadex (Org 25969) in Reversing Deep Neuromuscular Block Induced By Rocuronium or Vecuronium in Japanese Patients]." Masui. the Japanese Journal of Anesthesiology, vol. 63, no. 10, 2014, pp. 1083-8.
Takeda J, Iwasaki H, Otagiri T, et al. [Efficacy and safety of sugammadex (Org 25969) in reversing deep neuromuscular block induced by rocuronium or vecuronium in Japanese patients]. Masui. 2014;63(10):1083-8.
Takeda, J., Iwasaki, H., Otagiri, T., Katoh, T., Shingu, K., Obara, H., Nakatsuka, H., Tomiyama, Y., & Kasaba, T. (2014). [Efficacy and safety of sugammadex (Org 25969) in reversing deep neuromuscular block induced by rocuronium or vecuronium in Japanese patients]. Masui. the Japanese Journal of Anesthesiology, 63(10), 1083-8.
Takeda J, et al. [Efficacy and Safety of Sugammadex (Org 25969) in Reversing Deep Neuromuscular Block Induced By Rocuronium or Vecuronium in Japanese Patients]. Masui. 2014;63(10):1083-8. PubMed PMID: 25693333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Efficacy and safety of sugammadex (Org 25969) in reversing deep neuromuscular block induced by rocuronium or vecuronium in Japanese patients]. AU - Takeda,Junzo, AU - Iwasaki,Hiroshi, AU - Otagiri,Tetsutaro, AU - Katoh,Takasumi, AU - Shingu,Koh, AU - Obara,Hidefumi, AU - Nakatsuka,Hideki, AU - Tomiyama,Yoshinobu, AU - Kasaba,Toshiharu, PY - 2015/2/20/entrez PY - 2015/2/20/pubmed PY - 2015/3/24/medline SP - 1083 EP - 8 JF - Masui. The Japanese journal of anesthesiology JO - Masui VL - 63 IS - 10 N2 - BACKGROUND: Efficacy and safety of sugammadex in reversing neuromuscular block induced by rocuronium or vecuronium were investgated in Japanese patients. METHODS: We studied 99 Japanese patients undergoing surgery requiring general anesthesia. Patients were allocated randomly to receive intubation dose of rocuronium or vecuronium. During surgery, patients received additional dose of rocuronium or vecuronium for maintenance of deep block. At 1-2 PTC, 0.5-8.0 mg . kg-1 of sugammadex was administered. The neuromuscular block was monitored with acceleromyography using TOF stimuli. Sevoflurane was administered to all treatment groups after intubation. RESULTS: For the rocuronium-induced neuromuscular block, the mean recovery time of the T4/T1 ratio to 0.9 decreased from 66.9 min in the sugammadex 0.5 mg kg-1 group to 1.3 min in the sugammadex 8.0 mg kg-1 group. For the vecuronium-induced neuromuscular block it decreased from 79.5 min in the sugammadex 0.5 mg . kg-1 group to 2.9 min in the sugammadex 8.0 mg . kg-1 group. No clinical evidence of recurarization or residual curarization was observed. CONCLUSIONS: The efficacy and safety of sugammadex were confirmed in Japanese surgical patients for reversal from deep block. SN - 0021-4892 UR - https://www.unboundmedicine.com/medline/citation/25693333/[Efficacy_and_safety_of_sugammadex__Org_25969__in_reversing_deep_neuromuscular_block_induced_by_rocuronium_or_vecuronium_in_Japanese_patients]_ L2 - https://ClinicalTrials.gov/search/term=25693333 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -