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Contemporary and emerging strategies for eliminating human African trypanosomiasis due to Trypanosoma brucei gambiense: review.
Trop Med Int Health. 2015 Jun; 20(6):707-18.TM

Abstract

OBJECTIVES

To review current and emerging tools for Gambiense HAT control and elimination, and propose strategies that integrate these tools with epidemiological evidence.

METHODS

We reviewed the scientific literature to identify contemporary and emerging tools and strategies for controlling and eliminating Gambiense HAT. Through an iterative process involving key stakeholders, we then developed comprehensive scenarios leading to elimination, considering both established and new tools for diagnosis, case treatment and vector control.

RESULTS

Core components of all scenarios include detecting and treating cases with established or emerging techniques. Relatively more intensive scenarios incorporate vector control. New tools considered include tiny targets for tsetse fly control, use of rapid diagnostic tests and oral treatment with fexinidazole or oxaboroles. Scenarios consider the time when critical new tools are expected to become ready for deployment by national control programmes. Based on a review of the latest epidemiological data, we estimate the various interventions to cover 1,380,600 km(2) and 56,986,000 people.

CONCLUSIONS

A number of new tools will fill critical gaps in the current armamentarium for diagnosing and treating Gambiense HAT. Deploying these tools in endemic areas will facilitate the comprehensive and sustainable control of the disease considerably and contribute to the ultimate goal of elimination.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Steinmann P
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, Basel, Switzerland.
Stone CM
No affiliation info available
Sutherland CS
No affiliation info available
Tanner M
No affiliation info available
Tediosi F
No affiliation info available

MeSH

AfricaAnimalsDisease EradicationHumansInsect VectorsNeglected DiseasesPublic HealthTrypanosoma brucei gambienseTrypanosomiasis, AfricanTsetse Flies

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

25694261

Citation

Steinmann, Peter, et al. "Contemporary and Emerging Strategies for Eliminating Human African Trypanosomiasis Due to Trypanosoma Brucei Gambiense: Review." Tropical Medicine & International Health : TM & IH, vol. 20, no. 6, 2015, pp. 707-18.
Steinmann P, Stone CM, Sutherland CS, et al. Contemporary and emerging strategies for eliminating human African trypanosomiasis due to Trypanosoma brucei gambiense: review. Trop Med Int Health. 2015;20(6):707-18.
Steinmann, P., Stone, C. M., Sutherland, C. S., Tanner, M., & Tediosi, F. (2015). Contemporary and emerging strategies for eliminating human African trypanosomiasis due to Trypanosoma brucei gambiense: review. Tropical Medicine & International Health : TM & IH, 20(6), 707-18. https://doi.org/10.1111/tmi.12483
Steinmann P, et al. Contemporary and Emerging Strategies for Eliminating Human African Trypanosomiasis Due to Trypanosoma Brucei Gambiense: Review. Trop Med Int Health. 2015;20(6):707-18. PubMed PMID: 25694261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Contemporary and emerging strategies for eliminating human African trypanosomiasis due to Trypanosoma brucei gambiense: review. AU - Steinmann,Peter, AU - Stone,Christopher M, AU - Sutherland,C Simone, AU - Tanner,Marcel, AU - Tediosi,Fabrizio, Y1 - 2015/03/12/ PY - 2015/2/20/entrez PY - 2015/2/20/pubmed PY - 2015/7/7/medline KW - Gambiense HAT KW - TAH Gambiense KW - THA gambiense KW - control KW - contrôle KW - eliminación KW - elimination KW - escenarios KW - estrategias KW - human African trypanosomiasis KW - scenarios KW - scénarios KW - strategies KW - stratégies KW - tripanosomiasis Africana humana KW - trypanosomiase humaine africaine KW - élimination SP - 707 EP - 18 JF - Tropical medicine & international health : TM & IH JO - Trop Med Int Health VL - 20 IS - 6 N2 - OBJECTIVES: To review current and emerging tools for Gambiense HAT control and elimination, and propose strategies that integrate these tools with epidemiological evidence. METHODS: We reviewed the scientific literature to identify contemporary and emerging tools and strategies for controlling and eliminating Gambiense HAT. Through an iterative process involving key stakeholders, we then developed comprehensive scenarios leading to elimination, considering both established and new tools for diagnosis, case treatment and vector control. RESULTS: Core components of all scenarios include detecting and treating cases with established or emerging techniques. Relatively more intensive scenarios incorporate vector control. New tools considered include tiny targets for tsetse fly control, use of rapid diagnostic tests and oral treatment with fexinidazole or oxaboroles. Scenarios consider the time when critical new tools are expected to become ready for deployment by national control programmes. Based on a review of the latest epidemiological data, we estimate the various interventions to cover 1,380,600 km(2) and 56,986,000 people. CONCLUSIONS: A number of new tools will fill critical gaps in the current armamentarium for diagnosing and treating Gambiense HAT. Deploying these tools in endemic areas will facilitate the comprehensive and sustainable control of the disease considerably and contribute to the ultimate goal of elimination. SN - 1365-3156 UR - https://www.unboundmedicine.com/medline/citation/25694261/Contemporary_and_emerging_strategies_for_eliminating_human_African_trypanosomiasis_due_to_Trypanosoma_brucei_gambiense:_review_ DB - PRIME DP - Unbound Medicine ER -